9YR企业会员
发布人：长沙上禾生物科技有限公司
发布日期:2026/4/3 13:27:00
长沙上禾生物科技有限公司是一家致力于植物天然活性成分研发、生产与销售的国家级高新技术企业。我们专注于从全球珍贵植物资源中发现、提取、纯化具有明确生物功能和市场潜力的高价值天然产物。公司建立了符合GMP、ISO22000、HALAL、KOSHER等国际标准的现代化生产基地，配备了包括超临界CO₂萃取、制备型高效液相色谱、高速逆流色谱在内的先进提取纯化系统，以及HPLC、LC-MS、GC-MS、NMR等精密分析仪器。我们凭借科学的质量管理体系、专业的研发团队和丰富的应用经验，为全球膳食补充剂、功能食品、化妆品及医药研发领域提供高品质、标准化、可定制的植物活性原料及技术服务。
Changsha Sunho Bio-Tech Co., Ltd. is a national high-tech enterprise dedicated to the R&D, production, and sales of natural plant active ingredients. We focus on discovering, extracting, and purifying high-value natural products with defined biological functions and market potential from precious global botanical resources. The company has established a modern production base compliant with international standards such as GMP, ISO22000, HALAL, and KOSHER, equipped with advanced extraction and purification systems including supercritical CO₂ extraction, preparative HPLC, and high-speed counter-current chromatography, as well as sophisticated analytical instruments like HPLC, LC-MS, GC-MS, and NMR. Leveraging a scientific quality management system, a professional R&D team, and extensive application experience, we provide high-quality, standardized, and customizable botanical active ingredients and technical services for the global dietary supplement, functional food, cosmetic, and pharmaceutical R&D sectors.
产品概览 | Product Overview
倒捻子素，又名α-倒捻子素 或γ-倒捻子素，是主要从藤黄果 果皮中分离提取的一种天然氧杂蒽酮 类化合物。它是藤黄果中最具生物活性的标志性成分之一，具有卓越的广谱抗炎、强效抗氧化、调节代谢、抗菌、抗过敏、神经保护、抗肿瘤 等多重生物活性。倒捻子素通过抑制环氧合酶、5-脂氧合酶、核因子-κB、丝裂原活化蛋白激酶 等关键炎症信号通路，发挥强大的抗炎作用。其抗氧化能力远超维生素C和维生素E。作为一种高效、多靶点的天然活性分子，倒捻子素在抗炎镇痛、代谢综合征管理、皮肤健康、神经退行性疾病辅助干预 以及高端化妆品 等领域具有广阔的应用前景。
Mangostin, also known as α-mangostinorγ-mangostin, is a natural xanthonecompound primarily isolated and extracted from the pericarp of the mangosteenfruit (Garcinia mangostanaL.). It is one of the most bioactive and iconic components of mangosteen, possessing multiple biological activities including superior broad-spectrum anti-inflammatory, potent antioxidant, metabolic regulation, antibacterial, anti-allergic, neuroprotective, and anti-tumorproperties. Mangostin exerts its powerful anti-inflammatory effects byinhibiting key inflammatory signaling pathways such as cyclooxygenase, 5-lipoxygenase, nuclear factor-kappa B, and mitogen-activated protein kinases. Its antioxidant capacity far exceeds that of vitamin C and vitamin E. As a highly effective, multi-target natural active molecule, mangostin holds broad application prospects in areas such as anti-inflammatory and analgesic, metabolic syndrome management, skin health, adjunctive intervention in neurodegenerative diseases, andhigh-end cosmetics.
抑制促炎介质生成： 倒捻子素能有效抑制环氧合酶-1、环氧合酶-2、5-脂氧合酶 的活性，从而阻断前列腺素E₂、白三烯B₄ 等经典炎症介质的生物合成，其抗炎效力与部分非甾体抗炎药相当。
*Inhibits Pro-inflammatory Mediator Production: Mangostin effectively inhibits the activity of *cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase, thereby blocking the biosynthesis of classic inflammatory mediators like prostaglandin E₂ and leukotriene B₄. Its anti-inflammatory potency is comparable to some non-steroidal anti-inflammatory drugs.
调节炎症信号通路： 通过抑制核因子-κB 的激活和易位，以及丝裂原活化蛋白激酶 的磷酸化，下调肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6、诱导型一氧化氮合酶、环氧合酶-2 等关键炎症因子的基因表达，从源头控制炎症反应。
*Modulates Inflammatory Signaling Pathways: By inhibiting the activation and translocation of nuclear factor-kappa Band the phosphorylation ofmitogen-activated protein kinases, it downregulates the gene expression of key inflammatory factors such as tumor necrosis factor-alpha, interleukin-1β, interleukin-6, inducible nitric oxide synthase, cyclooxygenase-2, controlling the inflammatory response at its source.
直接清除自由基： 倒捻子素的化学结构使其成为强大的电子供体，能直接有效地清除超氧阴离子、过氧化氢、羟基自由基、过氧亚硝基 等多种活性氧和活性氮自由基，保护细胞膜、蛋白质和DNA免受氧化损伤。
*Directly Scavenges Free Radicals: The chemical structure of mangostin makes it a powerful electron donor, enabling it to directly and effectively scavenge various reactive oxygen and nitrogen species such as superoxide anion, hydrogen peroxide, hydroxyl radical, peroxynitrite, protecting cell membranes, proteins, and DNA from oxidative damage.
激活内源性防御系统： 上调细胞内超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶、血红素加氧酶-1 等抗氧化酶的表达，并促进核因子E2相关因子2 信号通路，增强细胞自身的抗氧化防御能力。
*Activates Endogenous Defense Systems: Upregulates the expression of intracellular antioxidant enzymes like *superoxide dismutase, glutathione peroxidase, catalase, heme oxygenase-1and promotes the nuclear factor erythroid 2-related factor 2signaling pathway, enhancing the cell's intrinsic antioxidant defense capacity.
抑制脂肪生成： 通过下调过氧化物酶体增殖物激活受体γ、CCAAT增强子结合蛋白α、固醇调节元件结合蛋白-1c 等脂肪生成关键转录因子的表达，抑制前脂肪细胞分化 和脂肪细胞中甘油三酯的积累。
*Inhibits Adipogenesis: By downregulating the expression of key adipogenic transcription factors such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein alpha, sterol regulatory element-binding protein-1c, it inhibitspreadipocyte differentiationand triglyceride accumulation in adipocytes.
改善胰岛素敏感性： 激活腺苷酸活化蛋白激酶 通路，促进骨骼肌和脂肪细胞的葡萄糖摄取，并抑制肝脏糖异生，有助于改善胰岛素抵抗 和血糖稳态。
*Improves Insulin Sensitivity: Activates the AMP-activated protein kinasepathway, promotingglucose uptakein skeletal muscle and adipose cells, and inhibiting hepatic gluconeogenesis, thereby helping to improveinsulin resistanceand glucose homeostasis.
调节脂质代谢： 有助于降低血清总胆固醇、低密度脂蛋白胆固醇、甘油三酯 水平，并可能提升高密度脂蛋白胆固醇。
*Modulates Lipid Metabolism: Helps lower serum levels of *total cholesterol, LDL-cholesterol, triglycerides, and may increase HDL-cholesterol.
抗菌与抗真菌： 对金黄色葡萄球菌、表皮葡萄球菌、痤疮丙酸杆菌、白色念珠菌、马拉色菌 等多种皮肤病原菌具有抑制作用，可用于痤疮、皮炎、皮肤感染 的辅助管理。
*Antibacterial & Antifungal: Exhibits inhibitory effects against various skin pathogens such as *Staphylococcus aureus, Staphylococcus epidermidis, Cutibacterium acnes, Candida albicans, Malassezia spp., and can be used in the adjunctive management of acne, dermatitis, skin infections.
神经保护： 能够穿过血脑屏障，通过其抗氧化、抗炎、抗凋亡特性，对β-淀粉样蛋白 和6-羟基多巴胺 诱导的神经元损伤具有保护作用，在阿尔茨海默病、帕金森病 的干预中具有研究潜力。
*Neuroprotection: Capable of crossing the blood-brain barrier, it protects against neuronal damage induced bybeta-amyloidand *6-hydroxydopaminethrough its antioxidant, anti-inflammatory, and anti-apoptotic properties, showing research potential in interventions for Alzheimer's disease and Parkinson's disease.
抗过敏： 通过稳定肥大细胞 膜，抑制组胺、类胰蛋白酶 等过敏介质的释放，减轻I型超敏反应。
*Anti-allergic: Stabilizes mast cellmembranes, inhibiting the release of allergic mediators likehistamine, tryptase, thereby alleviating type I hypersensitivity reactions.
产品名称 Product Name
规格/纯度 Specification/Purity
外观/特性 Appearance/Characteristics
主要应用 Main Applications
藤黄果提取物 (标准化倒捻子素)
Mangosteen P.E. (Standardized Mangostin)
倒捻子素 10%, 20%, 40%
总氧杂蒽酮 20%, 40%, 60%
Mangostin 10%, 20%, 40%
Total Xanthones 20%, 40%, 60%
棕黄色至黄棕色精细粉末，特征性苦味。
Brown-yellow to yellow-brown fine powder, characteristic bitter taste.
作为通用原料，用于抗炎、抗氧化、关节健康、体重管理、增强免疫力 等方向的膳食补充剂、功能性食品。
*Serves as a general raw material for *dietary supplements and functional foodstargeting anti-inflammatory, antioxidant, joint health, weight management, immune enhancement, etc.
高纯度倒捻子素 (α-倒捻子素)
High Purity α-Mangostin
α-倒捻子素 ≥ 90%, 95%, 98%, 99%
α-Mangostin ≥ 90%, 95%, 98%, 99%
淡黄色至黄色结晶性粉末，纯度越高颜色越浅。脂溶性，几乎不溶于水。
Pale yellow to yellow crystalline powder, lighter color with higher purity. Fat-soluble, almost insoluble in water.
用于高端抗炎、抗氧化、神经保护、抗肿瘤 的医药研发、高端保健品、功效型化妆品、科研试剂。
*Used in *pharmaceutical R&D, premium health products, efficacious cosmetics, research reagentsfor high-end anti-inflammatory, antioxidant, neuroprotective, anti-tumorapplications.
倒捻子素复合物 (α/γ混合)
Mangostin Complex (α/γ mixture)
α-倒捻子素 + γ-倒捻子素 ≥ 50%, 70%, 90%
(特定比例，如 4:1)
α-Mangostin + γ-Mangostin ≥ 50%, 70%, 90%
(Specific ratio, e.g., 4:1)
黄色至黄棕色粉末。研究表明α与γ型在抗炎等方面可能存在协同效应。
Yellow to yellow-brown powder. Research suggests potential synergistic effects between α- and γ- forms in anti-inflammation, etc.
用于追求协同功效的膳食补充剂、功能性食品、化妆品 配方。
*Used in formulations for dietary supplements, functional foods, cosmeticswhere synergistic effects are desired.
水溶性倒捻子素衍生物
Water-Soluble Mangostin Derivatives
倒捻子素含量 5%-20% (基于载体)
Mangostin content 5%-20% (on carrier basis)
或 磷脂复合物/环糊精包合物
or Phospholipid Complex/Cyclodextrin Inclusion Compound
黄色粉末或颗粒，经磷脂复合、环糊精包合、微胶囊化、纳米化 等处理，提高水溶性和生物利用度。
*Yellow powder or granules, processed via phospholipid complexation, cyclodextrin inclusion, microencapsulation, nano-sizingto enhance water solubility and bioavailability.
专为水性饮料、口服液、透明化妆品、注射剂 等对水溶性有要求的剂型设计。
*Specifically designed for dosage forms requiring water solubility, such as aqueous beverages, oral liquids, transparent cosmetics, injectables.
藤黄果全果粉/果皮粉
Whole Mangosteen Fruit Powder/Pericarp Powder
倒捻子素 ≥ 1%, 2%
总氧杂蒽酮 ≥ 3%, 5%
Mangostin ≥ 1%, 2%
Total Xanthones ≥ 3%, 5%
(富含多酚、多糖、膳食纤维)
(Rich in polyphenols, polysaccharides, dietary fiber)
棕色粉末，保留了藤黄果的全营养成分和天然风味。
Brown powder, retains the full nutritional profile and natural flavor of mangosteen.
作为天然色素、营养补充剂、风味物质，用于固体饮料、代餐粉、压片糖果、烘焙食品。
*Used as a *natural colorant, nutritional supplement, flavoring agentin solid beverages, meal replacement powders, pressed candies, baked goods.
通用质量标准 (以倒捻子素20%藤黄果提取物为例) | General Quality Standards (Example for 20% Mangostin Mangosteen Extract)
外观： 棕黄色至黄棕色粉末，具有本品特有气味，味苦。
Appearance: Brown-yellow to yellow-brown powder, with characteristic odor, bitter taste.
鉴别 (TLC/HPLC)： 与倒捻子素标准品一致。
Identification (TLC/HPLC): Complies with mangostin standard.
含量 (HPLC)： α-倒捻子素 ≥ 20.0%；总氧杂蒽酮 ≥ 40.0%。
Assay (HPLC): α-Mangostin ≥ 20.0%; Total Xanthones ≥ 40.0%.
干燥失重： ≤ 5.0%。
Loss on Drying: ≤ 5.0%.
炽灼残渣： ≤ 5.0%。
Residue on Ignition: ≤ 5.0%.
重金属： 铅(Pb) ≤ 3.0 mg/kg, 砷(As) ≤ 2.0 mg/kg, 汞(Hg) ≤ 0.2 mg/kg, 镉(Cd) ≤ 1.0 mg/kg。
Heavy Metals: Lead (Pb) ≤ 3.0 mg/kg, Arsenic (As) ≤ 2.0 mg/kg, Mercury (Hg) ≤ 0.2 mg/kg, Cadmium (Cd) ≤ 1.0 mg/kg.
农药残留： 符合客户指定标准 (如欧盟EC 396/2005)。
Pesticide Residues: Complies with customer-specified standards (e.g., EU EC 396/2005).
微生物： 总需氧菌 ≤ 1000 CFU/g, 霉菌和酵母菌 ≤ 100 CFU/g, 大肠杆菌、沙门氏菌不得检出。
Microbiology: TAC ≤ 1000 CFU/g, TYMC ≤ 100 CFU/g, E. coli, Salmonella negative.
包装与储存 | Packaging & Storage
包装： 1kg/铝箔袋，5kg/铝箔袋，10kg/纸板桶，25kg/纸板桶。内袋抽真空或充氮保护，密封避光防潮。
Packaging: 1kg/aluminum foil bag, 5kg/aluminum foil bag, 10kg/paper drum, 25kg/paper drum. Inner bags vacuum-sealed or nitrogen-flushed, sealed, light-proof, moisture-proof.
储存： 密封，置于阴凉、干燥、避光 处，温度建议< 20°C。高纯度倒捻子素对光、热、氧 敏感，建议2-8°C 冷藏长期储存。保质期一般为24个月。
*Storage: Store in a sealed container in a cool, dry, darkplace, recommended temperature< 20°C. High-purity mangostin is sensitive to light, heat, oxygen, and long-term storage at2-8°Cis recommended. Shelf life is typically 24 months.
膳食补充剂与保健食品：
关节与肌肉健康： 用于缓解骨关节炎、类风湿关节炎、运动后肌肉酸痛、软组织炎症 的补充剂，其抗炎作用机制与NSAIDs类似但更安全，常与姜黄素、葡萄糖胺、软骨素、透明质酸 等复配。
*Joint & Muscle Health: Used in supplements for *alleviating osteoarthritis, rheumatoid arthritis, post-exercise muscle soreness, soft tissue inflammation. Its anti-inflammatory mechanism is similar to NSAIDs but safer. Often combined with curcumin, glucosamine, chondroitin, hyaluronic acid, etc.
代谢健康与体重管理： 作为改善胰岛素抵抗、辅助调节血糖血脂、控制体重、减少内脏脂肪 的功能成分，用于代谢综合征 相关产品。
*Metabolic Health & Weight Management: Serves as a functional ingredient for *improving insulin resistance, assisting in blood sugar and lipid regulation, weight control, reducing visceral fat, used in products related to metabolic syndrome.
抗氧化与抗衰老： 用于抗自由基、延缓衰老、保护心血管、增强免疫力 的补充剂。
*Antioxidant & Anti-aging: Used in supplements for anti-free radical, anti-aging, cardiovascular protection, immune enhancement.
化妆品与个人护理：
抗炎舒缓： 用于敏感肌护理、抗红血丝、修复皮肤屏障、舒缓湿疹、特应性皮炎、痤疮 的精华、面霜、乳液、面膜、洗发水、沐浴露。
*Anti-inflammatory & Soothing: Used in *serums, creams, lotions, masks, shampoos, body washesfor sensitive skin care, anti-redness, skin barrier repair, soothing eczema, atopic dermatitis, acne.
抗氧化与抗衰老： 用于抗皱、紧致、提亮、修复光老化、抵御环境污染 的功效型护肤品。
*Antioxidant & Anti-aging: Used in efficacious skincare products for anti-wrinkle, firming, brightening, repairing photoaging, protecting against environmental pollution.
祛痘与控油： 凭借其抗痤疮丙酸杆菌、抗炎、调节皮脂 的作用，用于祛痘精华、控油乳液、洁面产品。
*Acne Treatment & Oil Control: Leveraging its effects against *Cutibacterium acnes, anti-inflammatory, and sebum regulation, used in acne serums, oil-control lotions, cleansers.
医药与科研领域：
作为先导化合物 或活性成分，用于新型抗炎药、镇痛药、代谢性疾病治疗药、神经保护剂、抗癌药物 的研发。
*Serves as a lead compoundoractive ingredientin the R&D of novel anti-inflammatory drugs, analgesics, metabolic disease therapeutics, neuroprotective agents, anticancer drugs.
用于细胞与分子生物学 研究，探索其在炎症、氧化应激、凋亡、自噬 等通路中的作用机制。
*Used in *cell and molecular biologyresearch to explore its mechanisms of action in pathways related to inflammation, oxidative stress, apoptosis, autophagy, etc.
先进的定向分离与纯化技术：
我们采用高速逆流色谱、制备型高效液相色谱、大孔吸附树脂层析 等现代色谱技术，从藤黄果果皮中高效、高选择性、规模化地分离纯化倒捻子素单体。该工艺具有分离度高、产品纯度高、有机溶剂消耗少、目标成分活性损失小 的特点，可生产出纯度高达99% 以上的α-倒捻子素 和γ-倒捻子素 标准品及原料。
*We employ modern chromatographic techniques such as high-speed counter-current chromatography, preparative high-performance liquid chromatography, and macroporous adsorption resin chromatographyto efficiently, selectively, and scalably isolate and purify mangostin monomers from mangosteen pericarp. This process is characterized byhigh resolution, high product purity, low organic solvent consumption, and minimal loss of target component activity, enabling the production of α-mangostinandγ-mangostinstandards and raw materials with purity exceeding 99%.
深度研究与功效验证：
我们不仅提供标准化原料，更建立了倒捻子素活性研究平台，通过体外细胞模型、动物实验模型，系统研究其在抑制COX-2/5-LOX、调节NF-κB/MAPK通路、激活AMPK、抗氧化应激、抑制肿瘤细胞增殖 等方面的剂量-效应关系、作用机理、协同/拮抗效应，为客户的产品开发和功效宣称提供坚实的科学数据支持。
*Beyond providing standardized raw materials, we have established a Mangostin Bioactivity Research Platform. Throughin vitro cell models and animal experiment models, we systematically study its dose-response relationships, mechanisms of action, synergistic/antagonistic effectsin areas such asinhibiting COX-2/5-LOX, modulating NF-κB/MAPK pathways, activating AMPK, antioxidation stress, inhibiting tumor cell proliferation, providing solid scientific data supportfor our clients' product development and efficacy claims.
专业的制剂与稳定性解决方案：
针对倒捻子素脂溶性、水溶性差、见光易分解、生物利用度受限 的应用瓶颈，我们提供成熟的制剂与递送技术方案，包括磷脂复合物、环糊精包合物、固体分散体、纳米乳、脂质体、微胶囊 等。这些技术能显著提高倒捻子素的水分散性、光热稳定性、胃肠溶解度和生物利用度，使其能更广泛地应用于水性饮料、口服液、透明精华、软胶囊 等多样化剂型中。
*Addressing the application bottlenecks of mangostin's lipophilicity, poor water solubility, photosensitivity, and limited bioavailability, we provide matureformulation and delivery technology solutions, including phospholipid complexes, cyclodextrin inclusion compounds, solid dispersions, nanoemulsions, liposomes, microcapsules. These technologies can significantly improve mangostin'swater dispersibility, photothermal stability, gastrointestinal solubility, and bioavailability, enabling its broader application in diverse dosage forms such as aqueous beverages, oral liquids, transparent serums, softgels.
联系我们 | Contact Us
公司： 长沙上禾生物科技有限公司
Company: Changsha Sunho Bio-Tech Co., Ltd.
地址： 中国湖南省长沙市高新技术产业开发区...
Address: High-tech Industrial Development Zone, Changsha, Hunan Province, China...
电话： +86-731-xxxx xxxx
Tel: +86-731-xxxx xxxx
邮箱： sales@sunhobiotech.com
萃炼天然，赋能健康 | Refining Nature, Empowering Health
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