长沙上禾生物科技有限公司 | Changsha Sunho Bio-Tech Co., Ltd.

公司简介 | Company Profile

长沙上禾生物科技有限公司是一家专业从事天然植物活性成分研发、生产和销售的高新技术企业。我们致力于从全球优质植物资源中，通过现代生物技术手段，提取、分离、纯化出具有特定健康益处的标准化天然产物。公司拥有符合国际标准（GMP, ISO22000, HACCP, KOSHER, HALAL）的生产设施，配备了从提取、浓缩、纯化到干燥、包装的全套自动化生产线。我们始终以科学为基础，以质量为核心，致力于为全球健康产品、食品饮料、化妆品及药品研发企业提供高效、安全、稳定的植物提取物原料及系统化应用解决方案。

Changsha Sunho Bio-Tech Co., Ltd. is a high-tech enterprise specializing in the research, development, production, and sales of natural plant active ingredients. We are committed to extracting, isolating, and purifying standardized natural products with specific health benefits from premium global botanical resources through modern biotechnology. The company operates production facilities compliant with international standards (GMP, ISO22000, HACCP, KOSHER, HALAL) and is equipped with a complete automated production line from extraction, concentration, and purification to drying and packaging. Grounded in science and centered on quality, we are dedicated to providing efficient, safe, and stable botanical extract raw materials and systematic application solutions for global health product, food and beverage, cosmetic, and pharmaceutical R&D enterprises.

主打产品：石榴皮提取物 | Key Product: Pomegranate Peel Extract

产品概览 | Product Overview

石榴皮提取物 是以石榴果实的外果皮为原料，采用现代提取技术（如水提、醇提、超临界萃取等）制备的天然活性成分浓缩物。石榴皮，在传统医药中具有悠久的使用历史，现代科学研究揭示，其富含的鞣花酸、安石榴苷、没食子酸、鞣花单宁 等多元酚类化合物，是其卓越生物活性的物质基础。相比石榴汁，其抗氧化活性高出数十倍。我们的石榴皮提取物系列产品，以标准化的安石榴苷 和/或鞣花酸 含量为核心指标，具有强效抗氧化、抗炎、抗衰老、保护心血管、改善代谢、支持皮肤健康、维持肠道菌群平衡 等多重功效，是一种应用广泛的天然功能原料。

Pomegranate Peel Extractis a concentrated natural active ingredient prepared from the pericarp (outer peel) of pomegranate fruit using modern extraction techniques (such as water extraction, alcohol extraction, supercritical extraction, etc.). Pomegranate peel has a long history of use in traditional medicine. Modern scientific research reveals that its exceptional bioactivity stems from its rich content of polyphenolic compounds, including ellagic acid, punicalagin, gallic acid, and ellagitannins. Compared to pomegranate juice, its antioxidant activity is many times higher. Our pomegranate peel extract series, standardized withpunicalaginand/or ellagic acidcontent as the core indicators, possesses multiple efficacies such aspotent antioxidant, anti-inflammatory, anti-aging, cardiovascular protection, metabolic improvement, skin health support, and maintenance of gut microbiota balance, making it a widely applicable natural functional raw material.

核心药理与功效 | Core Pharmacology & Efficacy

1. 卓越的抗氧化与抗炎活性 | Superior Antioxidant & Anti-inflammatory Activity

• 多机制协同抗氧化： 石榴皮中的安石榴苷、鞣花酸、没食子酸 等多酚类物质，能通过直接清除自由基、整合金属离子、激活内源性抗氧化系统 等多重途径发挥强大的抗氧化作用。其抗氧化能力（以ORAC值 衡量）远超大多数常见水果和植物提取物，是维生素C的68倍、绿茶提取物的4倍。

• *Multi-mechanism Synergistic Antioxidant: Polyphenolic compounds in pomegranate peel, such as punicalagin, ellagic acid, and gallic acid, exert potent antioxidant effects through multiple pathways includingdirect free radical scavenging, metal ion chelation, and activation of endogenous antioxidant systems. Its antioxidant capacity (measured by *ORAC value) far exceeds that of most common fruits and plant extracts, being 68 times that of vitamin C and 4 times that of green tea extract.

• 调控关键炎症通路： 通过抑制核因子-κB、丝裂原活化蛋白激酶、白细胞介素-1β、肿瘤坏死因子-α、环氧合酶-2、诱导型一氧化氮合酶 等炎症信号通路的关键分子，有效减轻慢性低度炎症，这是肥胖、糖尿病、心血管疾病、关节炎、神经退行性疾病 的共同病理基础。

• *Modulation of Key Inflammatory Pathways: By inhibiting key molecules in inflammatory signaling pathways such as nuclear factor-kappa B, mitogen-activated protein kinases, interleukin-1β, tumor necrosis factor-alpha, cyclooxygenase-2, and inducible nitric oxide synthase, it effectively alleviateschronic low-grade inflammation, a common pathological basis for obesity, diabetes, cardiovascular diseases, arthritis, and neurodegenerative diseases.

2. 保护心血管与代谢健康 | Cardiovascular & Metabolic Health Protection

• 改善动脉粥样硬化： 通过抑制低密度脂蛋白氧化、减少血管内皮炎症、抑制血管平滑肌细胞增殖、促进一氧化氮生成 等多重机制，延缓动脉粥样硬化斑块的形成和发展。

• *Improves Atherosclerosis: Delays the formation and progression of atherosclerotic plaques through multiple mechanisms including inhibiting LDL oxidation, reducing vascular endothelial inflammation, inhibiting vascular smooth muscle cell proliferation, and promoting nitric oxide production.

• 辅助降血压： 其含有的多酚能抑制血管紧张素转换酶 活性，有助于舒张血管，从而辅助降低血压。

• *Assists in Lowering Blood Pressure: The contained polyphenols can inhibit angiotensin-converting enzymeactivity, helping to dilate blood vessels and thereby assist in lowering blood pressure.

• 改善胰岛素抵抗： 通过抗氧化、抗炎、激活腺苷酸活化蛋白激酶通路，改善骨骼肌、肝脏、脂肪组织 的胰岛素敏感性，辅助调节血糖。

• *Improves Insulin Resistance: By exerting *antioxidant, anti-inflammatory effects, and activating the AMP-activated protein kinase pathway, it improves insulin sensitivity in skeletal muscle, liver, and adipose tissue, assisting in blood glucose regulation.

3. 维护皮肤健康与抗光老化 | Skin Health Maintenance & Anti-photoaging

• 抗紫外线损伤： 口服或局部使用，可增加皮肤中抗氧化酶 活性，减少紫外线 诱导的活性氧、基质金属蛋白酶 生成，从而保护胶原蛋白、弹性纤维 免受降解，减轻红斑、色素沉着、皱纹 等光老化迹象。

• *Protects Against UV Damage: Oral or topical use can increase skin antioxidant enzymeactivity, reduceUV-induced generation of reactive oxygen species and matrix metalloproteinases, thereby protectingcollagen and elastin fibersfrom degradation and alleviating signs of photoaging such as erythema, hyperpigmentation, and wrinkles.

• 促进胶原合成： 通过激活转化生长因子-β1/Smad通路，刺激皮肤成纤维细胞 合成I型胶原蛋白，增强皮肤紧致度和弹性。

• *Promotes Collagen Synthesis: Stimulates skin fibroblaststo synthesizetype I collagenby activating the transforming growth factor-beta1/Smad pathway, enhancing skin firmness and elasticity.

• 抑制黑色素生成： 通过抑制酪氨酸酶 活性和黑色素细胞 的活性，有助于减轻色斑、提亮肤色。

• *Inhibits Melanogenesis: Helps reduce hyperpigmentation and brighten skin toneby inhibitingtyrosinaseactivity and melanocyteactivity.

4. 调节肠道微生态 | Modulation of Gut Microbiota

• 益生元效应： 石榴皮多酚在结肠中被肠道菌群代谢为尿石素 等活性代谢产物，这些产物具有更强的抗炎、抗氧化、抗衰老 活性。同时，它可以选择性促进双歧杆菌、乳酸杆菌 等有益菌的生长，抑制大肠杆菌、梭菌 等潜在有害菌的增殖，从而维持健康的肠道菌群平衡。

• *Prebiotic Effect: Pomegranate peel polyphenols are metabolized by gut microbiota in the colon into active metabolites like urolithins, which possess strongeranti-inflammatory, antioxidant, and anti-agingactivity. Simultaneously, they can selectively promote the growth of beneficial bacteria like *Bifidobacteria and Lactobacilli, and inhibit the proliferation of potentially harmful bacteria like Escherichia coli and Clostridia, thereby maintaining a healthy gut microbiota balance.

产品规格系列 | Product Specifications Series

通用质量标准 (以安石榴苷40%提取物为例) | General Quality Standards (Example for 40% Punicalagins Extract)

• 外观： 深棕色至红棕色粉末，具有本品特有气味，味涩。

• Appearance: Dark brown to reddish-brown powder, characteristic odor, astringent taste.

• 鉴别 (HPLC/UV)： 与安石榴苷、鞣花酸标准品一致。

• Identification (HPLC/UV): Complies with punicalagin and ellagic acid standards.

• 含量 (HPLC)：

• 安石榴苷 ≥ 40.0% (α-安石榴苷 + β-安石榴苷)。

• 鞣花酸 ≥ 2.0%。

• 总多酚 ≥ 50.0% (以没食子酸计)。

• Punicalagins ≥ 40.0% (α-Punicalagin + β-Punicalagin).

• Ellagic Acid ≥ 2.0%.

• Total Polyphenols ≥ 50.0% (calculated as gallic acid).

• 干燥失重： ≤ 5.0%。

• Loss on Drying: ≤ 5.0%.

• 灰分： ≤ 5.0%。

• Ash: ≤ 5.0%.

• 重金属： 铅(Pb) ≤ 3.0 mg/kg, 砷(As) ≤ 2.0 mg/kg, 汞(Hg) ≤ 0.2 mg/kg, 镉(Cd) ≤ 1.0 mg/kg。

• Heavy Metals: Lead (Pb) ≤ 3.0 mg/kg, Arsenic (As) ≤ 2.0 mg/kg, Mercury (Hg) ≤ 0.2 mg/kg, Cadmium (Cd) ≤ 1.0 mg/kg.

• 农药残留： 符合客户指定标准 (如欧盟EC 396/2005)。

• Pesticide Residues: Complies with customer-specified standards (e.g., EU EC 396/2005).

• 微生物： 总需氧菌 ≤ 1000 CFU/g, 霉菌和酵母菌 ≤ 100 CFU/g, 大肠杆菌、沙门氏菌、金黄色葡萄球菌不得检出。

• Microbiology: TAC ≤ 1000 CFU/g, TYMC ≤ 100 CFU/g, E. coli, Salmonella, S. aureus negative.

包装与储存 | Packaging & Storage

• 包装： 1kg/铝箔袋，5kg/铝箔袋，10kg/纸板桶，25kg/纸板桶。内袋抽真空或充氮保护，密封避光防潮。

• Packaging: 1kg/aluminum foil bag, 5kg/aluminum foil bag, 10kg/paper drum, 25kg/paper drum. Inner bags vacuum-sealed or nitrogen-flushed, sealed, light-proof, moisture-proof.

• 储存： 密封，置于阴凉、干燥、避光 处，建议温度< 25°C。避免高温、高湿和阳光直射。高纯度鞣花酸对光和氧化敏感，需更严格保存。保质期一般为24个月。

• *Storage: Store in a sealed container in a cool, dry, darkplace, recommended temperature< 25°C. Avoid high temperature, high humidity, and direct sunlight. High-purity ellagic acid is sensitive to light and oxidation, requiring stricter storage. Shelf life is typically 24 months.

主要应用领域 | Primary Application Fields

• 膳食补充剂与保健食品：

• 抗氧化与抗衰老： 用于抗自由基、延缓衰老、增强免疫力、保护DNA 的胶囊、片剂、粉剂、口服液。

• *Antioxidant & Anti-aging: Used in *capsules, tablets, powders, oral liquidsfor anti-free radical, anti-aging, immune enhancement, DNA protection.

• 心血管健康： 用于辅助降血压、调节血脂、保护血管内皮、预防动脉粥样硬化 的补充剂，常与葡萄籽提取物、辅酶Q10、山楂提取物 等复配。

• *Cardiovascular Health: Used in supplements for *assisting in lowering blood pressure, regulating blood lipids, protecting vascular endothelium, preventing atherosclerosis, often combined with grape seed extract, coenzyme Q10, hawthorn extract, etc.

• 关节健康： 利用其强大的抗炎作用，用于缓解关节炎、关节疼痛、僵硬 的关节健康产品。

• *Joint Health: Leveraging its potent anti-inflammatory effects, used in joint health products for alleviating arthritis, joint pain, stiffness.

• 体重与代谢管理： 用于改善胰岛素抵抗、辅助控制血糖、支持体重管理 的产品。

• *Weight & Metabolic Management: Used in products for improving insulin resistance, assisting in blood sugar control, supporting weight management.

• 功能性食品与饮料：

• 添加于功能饮料、果汁、茶饮、乳制品、酸奶、能量棒、糖果、巧克力 中，提供抗氧化、抗炎、保护心血管 等功能宣称，并赋予产品天然红宝石色泽和独特风味。

• *Added to functional beverages, juices, tea drinks, dairy products, yogurt, energy bars, candies, chocolateto provide functional claims likeantioxidant, anti-inflammatory, cardiovascular protection, and impart a natural ruby color and unique flavorto the product.

• 化妆品与个人护理：

• 抗衰老与光保护： 用于抗皱、紧致、提亮、修复、防晒 的精华、面霜、眼霜、面膜、防晒霜，保护皮肤免受紫外线、污染、蓝光 引起的氧化损伤和光老化。

• *Anti-aging & Photoprotection: Used in serums, creams, eye creams, masks, sunscreensforanti-wrinkle, firming, brightening, repair, sun protection, protecting skin from oxidative damage and photoaging caused by UV rays, pollution, blue light.

• 抗炎与舒缓： 用于敏感肌护理、舒缓红肿、抗痘、修复皮肤屏障 的产品。

• *Anti-inflammatory & Soothing: Used in products for sensitive skin care, soothing redness, anti-acne, skin barrier repair.

• 天然防腐： 作为天然防腐剂 和抗氧化剂，用于水剂、乳液、膏霜 中，替代或减少部分化学防腐剂。

• *Natural Preservation: Used as a natural preservativeandantioxidantin aqueous solutions, lotions, creamsto replace or reduce some chemical preservatives.

• 动物营养：

• 在宠物食品 中，用于宠物抗氧化、抗炎、支持关节健康、改善皮毛光泽、维持肠道健康 的补充剂。

• *Animal Nutrition: Used in *pet foodsupplements for antioxidant, anti-inflammatory, joint health support, improving coat shine, maintaining gut healthin pets.

• 在养殖业 中，作为天然抗氧化剂、抗应激剂、免疫增强剂、肉质改良剂 添加到饲料中。

• *In *livestock farming, added to feed as a natural antioxidant, anti-stress agent, immune enhancer, meat quality improver.

我们的核心优势 | Our Core Advantages

• 源头控制与工艺优化：

• 优选原料： 精选新疆、山东、安徽 等优质石榴产区的特定高多酚品种（如突尼斯软籽石榴、大青皮甜石榴），在最佳成熟期 采收，确保原料中安石榴苷、鞣花酸 等活性成分含量最大化。

• *Premium Raw Material Selection: We select specific high-polyphenol varieties(such asTunisian soft-seed pomegranate, Daqingpi sweet pomegranate) from high-quality producing regions like Xinjiang, Shandong, Anhui, harvesting at theoptimal maturity stageto ensure maximum levels of active components like punicalagin and ellagic acidin the raw material.

• 温和高效提取： 采用低温动态逆流提取、超声波辅助提取、超临界CO2萃取 等低热、短时、高效 的提取技术，最大限度地保留石榴皮中热敏性多酚 的完整结构和生物活性，避免传统高温长时间提取导致的降解和氧化。

• *Mild & Efficient Extraction: We employ low-temperature dynamic counter-current extraction, ultrasound-assisted extraction, supercritical CO2 extractionand otherlow-heat, short-time, high-efficiencyextraction technologies to maximally preserve the intact structure and bioactivity of the heat-sensitive polyphenolsin pomegranate peel, avoiding degradation and oxidation caused by traditional high-temperature, prolonged extraction.

• 标准化与指纹图谱质控：

• 我们不仅控制安石榴苷、鞣花酸、总多酚 等核心指标的含量，还建立了HPLC指纹图谱 质控标准，对没食子酸、鞣花单宁B、安石榴苷α/β、鞣花酸 等多种特征成分的含量与比例 进行监控，确保不同批次产品化学组成的高度一致性和生物活性的稳定再现性，为客户的配方提供可靠保障。

• *We not only control the content of core indicators like punicalagin, ellagic acid, total polyphenols, but have also established anHPLC fingerprintquality control standard. This monitors the content and ratioof various characteristic components likegallic acid, ellagitannin B, punicalagin α/β, ellagic acid, ensuring *high consistencyin chemical composition and stable reproducibilityof bioactivity across different batches, providing reliable assurance for our clients' formulations.

• 专业的应用支持与服务：

• 涩味解决方案： 针对石榴皮提取物天然的涩味，我们提供成熟的微胶囊化、风味掩蔽、甜味剂复配、pH调节 等方案，有效改善其在饮料、糖果、补充剂 等终端产品中的适口性。

• *Astringency Solution: To address the natural astringencyof pomegranate peel extract, we provide proven solutions likemicroencapsulation, flavor masking, sweetener blending, pH adjustment, effectively improving its *palatabilityin end products such as beverages, candies, supplements.

• 稳定性增强： 针对多酚类物质在光、热、氧、金属离子、碱性pH 下不稳定的特点，提供抗氧化剂、螯合剂、稳定剂、包埋技术、充氮包装 等全套稳定性解决方案，确保产品在货架期内保持最佳活性和外观。

• *Stability Enhancement: Addressing the instability of polyphenols under *light, heat, oxygen, metal ions, alkaline pH, we provide comprehensive stability solutions including antioxidants, chelating agents, stabilizers, encapsulation technologies, nitrogen-flushed packaging, ensuring the product maintains optimal activity and appearance throughout its shelf life.

• 功效配伍建议： 根据抗氧化、抗炎、心血管、皮肤健康、体重管理 等不同功效目标，我们可提供科学的复配方案。例如，与维生素C、维生素E、白藜芦醇、姜黄素、绿茶提取物、葡萄籽提取物 等成分协同，实现1+1>2 的增效作用。

• *Efficacy Formulation Recommendations: Based on different efficacy targets such as antioxidant, anti-inflammatory, cardiovascular, skin health, weight management, we can provide scientificformulation suggestions. For example, synergistic combinations with ingredients like *vitamin C, vitamin E, resveratrol, curcumin, green tea extract, grape seed extractcan achieve a 1+1>2enhanced effect.

联系我们 | Contact Us

• 公司： 长沙上禾生物科技有限公司

• Company: Changsha Sunho Bio-Tech Co., Ltd.

• 地址： 中国湖南省长沙市高新技术产业开发区...

• Address: High-tech Industrial Development Zone, Changsha, Hunan Province, China...

•