长沙上禾生物科技有限公司 | Changsha Sunho Bio-Tech Co., Ltd.

公司简介 | Company Profile

长沙上禾生物科技有限公司是一家专注于珍稀药用植物高价值活性成分研发、生产与销售的国家高新技术企业。我们聚焦于具有深厚传统应用背景和现代科学验证的天然化合物，致力于通过先进生物技术和绿色生产工艺，实现其标准化、规模化供应。公司拥有从植物育种、GAP种植、到现代化提取、纯化、检测的全产业链布局，核心生产设施符合cGMP、ISO22000、HALAL、KOSHER等国际管理体系标准。凭借深厚的技术积累和严格的质量控制，我们为全球医药、功能食品、高端化妆品及科研机构提供稳定、高效、可追溯的植物活性原料及定制化解决方案。

Changsha Sunho Bio-Tech Co., Ltd. is a national high-tech enterprise specializing in the R&D, production, and sales of high-value active ingredients from rare medicinal plants. We focus on natural compounds with deep traditional application backgrounds and modern scientific validation, committed to achieving their standardized and large-scale supply through advanced biotechnology and green production processes. The company has established a full industrial chain layout from plant breeding, GAP cultivation, to modern extraction, purification, and testing. Our core production facilities comply with international management system standards such as cGMP, ISO22000, HALAL, and KOSHER. Leveraging profound technical expertise and stringent quality control, we provide stable, efficient, and traceable botanical active ingredients and customized solutions for the global pharmaceutical, functional food, high-end cosmetic, and scientific research sectors.

主打产品：桃叶珊瑚甙 | Key Product: Aucubin

产品概览 | Product Overview

桃叶珊瑚甙 是一种天然的环烯醚萜葡萄糖苷 类化合物，是多种传统药用植物的标志性活性成分，尤其在杜仲、车前草、栀子、地黄 等植物中含量丰富。在植物体内，它常以前体 形式存在，在特定条件下（如酶解、肠道微生物代谢）转化为具有更强生物活性的桃叶珊瑚甙元。现代药理学研究证实，桃叶珊瑚甙具有卓越的抗炎、保肝、抗氧化、神经保护、抗骨质疏松、抗高尿酸血症、促进伤口愈合、抗纤维化 等广泛的药理活性，尤其在对肝脏、肾脏、神经系统、骨骼、皮肤 的保护和修复方面表现突出。其作用机制独特，靶点明确，使其在保肝护肝、抗炎镇痛、骨关节健康、神经退行性疾病干预、皮肤修复、代谢病防治 等多个领域展现出巨大的应用潜力。

Aucubinis a natural iridoid glucosidecompound and a signature active ingredient in various traditional medicinal plants, particularly abundant in plants likeEucommia ulmoides, Plantago asiatica, Gardenia jasminoides, Rehmannia glutinosa. In plants, it often exists as a precursor, converting under specific conditions (such as enzymatic hydrolysis or gut microbial metabolism) into the more biologically activeaglycone, aucubigenin. Modern pharmacological studies confirm that aucubin possesses a wide range of pharmacological activities, including exceptional anti-inflammatory, hepatoprotective, antioxidant, neuroprotective, anti-osteoporotic, anti-hyperuricemic, wound healing promoting, and anti-fibroticeffects. It shows particularly remarkable performance in protecting and repairing theliver, kidneys, nervous system, bones, and skin. Its unique mechanisms of action and well-defined targets grant it immense application potential in multiple fields such as *liver protection, anti-inflammatory and analgesic, bone and joint health, intervention in neurodegenerative diseases, skin repair, and prevention of metabolic diseases.

核心药理与功效 | Core Pharmacology & Efficacy

1. 强大的抗炎与免疫调节作用 | Potent Anti-inflammatory & Immunomodulatory Effects

• 多靶点抑制炎症通路： 桃叶珊瑚甙能显著抑制脂多糖、白细胞介素-1β、肿瘤坏死因子-α 等诱导的炎症反应。其核心机制包括：

• *Multi-target Inhibition of Inflammatory Pathways: Aucubin significantly inhibits inflammatory responses induced by lipopolysaccharide, interleukin-1β, tumor necrosis factor-alpha. Its core mechanisms include:

• 抑制核因子-κB 信号通路的激活，下调环氧合酶-2、诱导型一氧化氮合酶、肿瘤坏死因子-α、白细胞介素-6、白细胞介素-1β 等关键促炎因子的表达。

• *Inhibiting the activation of the *nuclear factor-kappa Bsignaling pathway, downregulating the expression of key pro-inflammatory factors such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin-6, interleukin-1β.

• 抑制丝裂原活化蛋白激酶 家族成员p38、JNK、ERK 的磷酸化。

• *Inhibiting the phosphorylation of *mitogen-activated protein kinasefamily members p38, JNK, ERK.

• 抑制NLRP3炎症小体 的组装与活化，从而减少白细胞介素-1β、白细胞介素-18 的成熟与释放。

• *Inhibiting the assembly and activation of the *NLRP3 inflammasome, thereby reducing the maturation and release of interleukin-1β and interleukin-18.

• 调节免疫细胞功能： 调节巨噬细胞、T细胞、树突状细胞 的功能，从M1促炎型 向M2抗炎/修复型 极化，从而平衡过度免疫反应。

• *Modulation of Immune Cell Function: Regulates the function of macrophages, T cells, dendritic cells, promoting polarization from theM1 pro-inflammatory phenotypeto the M2 anti-inflammatory/repair phenotype, thereby balancing excessive immune responses.

2. 卓越的肝保护与肾保护作用 | Outstanding Hepatoprotective & Nephroprotective Effects

• 抗肝损伤： 对对乙酰氨基酚、四氯化碳、酒精、刀豆蛋白A、D-半乳糖胺 等多种化学性、免疫性肝损伤模型均显示出强大的保护作用。其机制包括：

• *Anti-hepatic Injury: Demonstrates potent protective effects against various chemical and immune-mediated liver injury models induced by acetaminophen, carbon tetrachloride, alcohol, concanavalin A, D-galactosamine. Mechanisms include:

• 强大的抗氧化 能力，清除活性氧/活性氮，提升谷胱甘肽、超氧化物歧化酶、谷胱甘肽过氧化物酶 等内源性抗氧化酶水平。

• *Potent antioxidantcapacity, scavengingreactive oxygen/nitrogen species, elevating levels of endogenous antioxidant enzymes like glutathione, superoxide dismutase, glutathione peroxidase.

• 抑制细胞色素P450 2E1 等代谢酶的过度激活，减少有毒代谢产物 的生成。

• *Inhibiting the overactivation of metabolic enzymes like *cytochrome P450 2E1, reducing the production of toxic metabolites.

• 抑制肝星状细胞 的活化与增殖，减轻肝纤维化。

• *Inhibiting the activation and proliferation of hepatic *stellate cells, alleviating liver fibrosis.

• 抑制肝细胞凋亡，保护线粒体 功能。

• *Inhibiting hepatocyte *apoptosis, protecting mitochondrialfunction.

• 抗肾损伤： 在糖尿病肾病、药物性肾损伤、缺血再灌注肾损伤 模型中，能减轻氧化应激、炎症、细胞凋亡、纤维化，保护肾功能，其机制与激活核因子E2相关因子2/血红素加氧酶-1 等通路相关。

• *Anti-renal Injury: In models of diabetic nephropathy, drug-induced kidney injury, ischemia-reperfusion kidney injury, it can alleviateoxidative stress, inflammation, apoptosis, fibrosis, protecting renal function, associated with mechanisms like activating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1pathway.

3. 显著的神经保护与抗骨质疏松作用 | Significant Neuroprotective & Anti-osteoporotic Effects

• 神经保护：

• 可穿过血脑屏障，对β-淀粉样蛋白、谷氨酸、6-羟基多巴胺、脑缺血/再灌注 诱导的神经元损伤具有保护作用。

• *Can cross the *blood-brain barrier, protecting against neuronal damage induced by beta-amyloid, glutamate, 6-hydroxydopamine, cerebral ischemia/reperfusion.

• 抑制小胶质细胞 过度活化，减轻神经炎症。

• *Inhibits the overactivation of *microglia, alleviating neuroinflammation.

• 促进神经生长因子 表达，支持神经元存活与生长。在阿尔茨海默病、帕金森病、脑卒中、抑郁症 等神经系统疾病的干预中具有潜力。

• *Promotes the expression of *nerve growth factor, supporting neuronal survival and growth. Has potential for intervention in neurological disorders such as Alzheimer's disease, Parkinson's disease, stroke, depression.

• 抗骨质疏松：

• 通过抑制破骨细胞 的分化与功能（下调核因子κB受体活化因子配体/核因子κB受体活化因子/骨保护素 系统），减少骨吸收。

• *By inhibiting the differentiation and function of *osteoclasts(downregulating the RANKL/RANK/OPGsystem), it reduces bone resorption.

• 促进成骨细胞 的增殖、分化和矿化，增加碱性磷酸酶、骨钙素、I型胶原 的表达。

• *Promotes the proliferation, differentiation, and mineralization of *osteoblasts, increasing the expression of alkaline phosphatase, osteocalcin, type I collagen.

• 调节Wnt/β-连环蛋白、骨形态发生蛋白/Smad 等成骨相关信号通路，有效改善卵巢切除、糖皮质激素诱导 的骨质疏松模型骨量丢失。

4. 促进皮肤修复与抗纤维化 | Promotion of Skin Repair & Anti-fibrotic Effects

• 促进伤口愈合： 通过抗氧化、抗炎、促进血管新生、刺激成纤维细胞增殖与胶原沉积、促进上皮化 等多重机制，加速急性和慢性伤口 的愈合过程。

• *Promotes Wound Healing: Accelerates the healing process of *acute and chronic woundsthrough multiple mechanisms including antioxidant, anti-inflammatory, promoting angiogenesis, stimulating fibroblast proliferation and collagen deposition, and promoting epithelialization.

• 抗皮肤光老化： 保护人真皮成纤维细胞 免受紫外线A 诱导的损伤，减少基质金属蛋白酶-1 的表达，保护胶原蛋白 免受降解。

• *Anti-skin Photoaging: Protects human dermal fibroblastsfromUVA-induced damage, reduces the expression of *matrix metalloproteinase-1, and protects collagenfrom degradation.

• 抗组织纤维化： 在肝、肺、肾、心肌 等多种器官纤维化模型中，通过抑制转化生长因子-β1/Smad 信号通路、上皮-间质转化 等过程，发挥抗纤维化作用。

• *Anti-tissue Fibrosis: Exerts anti-fibrotic effects in fibrosis models of various organs like liver, lung, kidney, myocardiumby inhibiting processes such as thetransforming growth factor-beta1/Smadsignaling pathway and epithelial-mesenchymal transition.

产品规格系列 | Product Specifications Series

通用质量标准 (以桃叶珊瑚甙20%杜仲提取物为例) | General Quality Standards (Example for 20% Aucubin Eucommia Extract)

• 外观： 棕黄色至黄棕色粉末，具有本品特有气味，味微苦。

• Appearance: Brown-yellow to yellow-brown powder, characteristic odor, slightly bitter taste.

• 鉴别 (TLC/HPLC)： 与桃叶珊瑚甙标准品一致。

• Identification (TLC/HPLC): Complies with aucubin standard.

• 含量 (HPLC)： 桃叶珊瑚甙 ≥ 20.0%。

• Assay (HPLC): Aucubin ≥ 20.0%.

• 干燥失重： ≤ 5.0%。

• Loss on Drying: ≤ 5.0%.

• 炽灼残渣： ≤ 5.0%。

• Residue on Ignition: ≤ 5.0%.

• 重金属： 铅(Pb) ≤ 3.0 mg/kg, 砷(As) ≤ 2.0 mg/kg, 汞(Hg) ≤ 0.2 mg/kg, 镉(Cd) ≤ 1.0 mg/kg。

• Heavy Metals: Lead (Pb) ≤ 3.0 mg/kg, Arsenic (As) ≤ 2.0 mg/kg, Mercury (Hg) ≤ 0.2 mg/kg, Cadmium (Cd) ≤ 1.0 mg/kg.

• 农药残留： 符合客户指定标准 (如欧盟EC 396/2005)。

• Pesticide Residues: Complies with customer-specified standards (e.g., EU EC 396/2005).

• 微生物： 总需氧菌 ≤ 1000 CFU/g, 霉菌和酵母菌 ≤ 100 CFU/g, 大肠杆菌、沙门氏菌不得检出。

• Microbiology: TAC ≤ 1000 CFU/g, TYMC ≤ 100 CFU/g, E. coli, Salmonella negative.

包装与储存 | Packaging & Storage

• 包装：

• 粉末： 1kg/铝箔袋，5kg/铝箔袋，10kg/纸板桶。内袋抽真空或充氮保护。

• Powder: 1kg/aluminum foil bag, 5kg/aluminum foil bag, 10kg/paper drum. Inner bags vacuum-sealed or nitrogen-flushed.

• 高纯度单体/甙元： 1g, 5g, 10g, 25g, 50g, 100g/棕色玻璃瓶，内附干燥剂，密封。大规格用铝箔袋+铝罐。

• High-purity monomer/aglycone: 1g, 5g, 10g, 25g, 50g, 100g/amber glass bottle, with desiccant, sealed. Larger specifications use aluminum foil bag + aluminum can.

• 储存： 密封，置于阴凉、干燥、避光 处。粉末建议温度< 25°C。高纯度桃叶珊瑚甙及其甙元 对光、热、湿、氧 高度敏感，建议-20°C 至 4°C 冷藏或冷冻，密封避光储存，开封后尽快使用。保质期一般为24个月（粉末），12个月（单体/甙元，需冷藏）。

• *Storage: Store in a sealed container in a cool, dry, darkplace. Powder recommended at< 25°C. High-purity aucubin and its aglyconeare highly sensitive tolight, heat, moisture, oxygen. Storage at -20°C to 4°C(refrigerated or frozen) in a sealed, light-proof container is recommended. Use promptly after opening. Shelf life is typically24 months(powder), 12 months(monomer/aglycone, requires refrigeration).

主要应用领域 | Primary Application Fields

• 药品与医药研发：

• 肝病辅助用药： 开发用于化学性肝损伤、酒精性肝病、药物性肝损伤、脂肪肝、肝纤维化 的保肝、抗炎、抗氧化 药物或辅助治疗产品。

• *Adjuvant Therapy for Liver Diseases: Developing *hepatoprotective, anti-inflammatory, antioxidantdrugs or adjunctive therapies for chemical liver injury, alcoholic liver disease, drug-induced liver injury, fatty liver, liver fibrosis.

• 抗炎镇痛药： 基于其强大的抗炎作用，开发新型非甾体抗炎药 或用于关节炎、软组织损伤、术后疼痛 管理的产品。

• *Anti-inflammatory & Analgesic Drugs: Developing novel *non-steroidal anti-inflammatory drugsor products for managing arthritis, soft tissue injuries, postoperative painbased on its potent anti-inflammatory effects.

• 骨质疏松治疗药： 作为抗骨质疏松 的候选药物，通过“双向调节”（抑制骨吸收、促进骨形成）发挥作用。

• *Osteoporosis Therapeutics: As a candidate drug for anti-osteoporosis, acting through "dual regulation" (inhibiting bone resorption, promoting bone formation).

• 神经保护剂： 用于阿尔茨海默病、帕金森病、脑卒中、抑郁症、神经性疼痛 等神经系统疾病的药物研发。

• *Neuroprotective Agents: Used in drug R&D for neurological disorders such as Alzheimer's disease, Parkinson's disease, stroke, depression, neuropathic pain.

• 膳食补充剂与保健食品：

• 肝健康： 用于解酒护肝、化学性肝损伤辅助保护、脂肪肝调理 的胶囊、片剂、口服液。

• *Liver Health: Used in *capsules, tablets, oral liquidsfor alcohol detoxification and liver protection, adjunctive protection against chemical liver injury, fatty liver regulation.

• 骨骼与关节健康： 用于预防和辅助改善骨质疏松、缓解关节炎、强健骨骼和韧带 的产品，常与钙、维生素D、硫酸软骨素、Ⅱ型胶原蛋白 等复配。

• *Bone & Joint Health: Used in products for *preventing and adjunctively improving osteoporosis, alleviating arthritis, strengthening bones and ligaments, often combined with calcium, vitamin D, chondroitin sulfate, type II collagen, etc.

• 抗炎与免疫调节： 用于慢性炎症、自身免疫性疾病辅助管理、增强免疫力 的补充剂。

• *Anti-inflammatory & Immunomodulation: Used in supplements for adjuvant management of chronic inflammation, autoimmune diseases, immune enhancement.

• 化妆品与个人护理：

• 抗炎舒缓： 用于敏感肌、泛红、皮炎、湿疹、痤疮 的修复、舒缓、抗红 类护肤品。

• *Anti-inflammatory & Soothing: Used in *repair, soothing, anti-rednessskincare products for sensitive skin, redness, dermatitis, eczema, acne.

• 抗衰老与修复： 用于抗皱、紧致、促进胶原生成、修复光老化、促进伤口愈合 的精华、面霜、眼霜、修复面膜、疤痕修复产品。

• *Anti-aging & Repair: Used in *serums, creams, eye creams, repair masks, scar repair productsfor anti-wrinkle, firming, promoting collagen production, repairing photoaging, promoting wound healing.

• 兽药与宠物营养：

• 开发用于宠物肝病、关节炎、皮肤炎症、伤口愈合 的治疗或保健产品。

• *Developed for *therapeutic or health productsfor pets addressing liver disease, arthritis, skin inflammation, wound healing.

我们的核心优势 | Our Core Advantages

• 先进提取与纯化技术平台：

• 针对桃叶珊瑚甙水溶性好、热敏性、易被植物内源酶降解 的特性，我们采用低温动态逆流提取、膜分离浓缩、大孔树脂吸附色谱、高速逆流色谱、制备型高效液相色谱 等组合工艺。特别是低温提取 和快速灭酶 步骤，有效防止了提取过程中桃叶珊瑚甙被β-葡萄糖苷酶 分解为不稳定的甙元，确保了最终产品中桃叶珊瑚甙的高收率和高纯度，可稳定提供从10%到99% 的系列化产品。

• Addressing the characteristics of aucubin—good water solubility, heat sensitivity, susceptibility to degradation by plant endogenous enzymes—we employ a combination of processes including low-temperature dynamic counter-current extraction, membrane separation and concentration, macroporous resin adsorption chromatography, high-speed counter-current chromatography, preparative high-performance liquid chromatography. Particularly, thelow-temperature extractionand rapid enzyme deactivationsteps effectively prevent the decomposition of aucubin into its unstable aglycone byβ-glucosidaseduring extraction, ensuring a *high yield and high purity of aucubinin the final product. We can stably supply a series of products ranging from 10% to 99%purity.

• 深入的代谢与机制研究：

• 我们不仅提供原料，更建有完善的体内外药效评价平台。我们深入研究桃叶珊瑚甙在体内的药代动力学（吸收、分布、代谢、排泄）过程，特别是其肠道菌群代谢 生成活性代谢产物桃叶珊瑚甙元 的规律。同时，我们通过细胞模型、分子生物学技术、动物模型，系统阐明了其在抗氧化、抗炎、保肝、抗骨质疏松、神经保护 等方面的具体信号通路与分子靶点（如Nrf2/HO-1, NF-κB, MAPK, TGF-β1/Smad, RANKL/RANK/OPG, Wnt/β-catenin），为客户的产品开发和功效宣称提供坚实的机制层面 的科学依据。

• *Beyond providing raw materials, we have established a comprehensive in vitro and in vivo efficacy evaluation platform. We conduct in-depth research on thepharmacokinetics(absorption, distribution, metabolism, excretion) of aucubin in vivo, particularly the pattern of its metabolism by gut microbiotato generate the active metaboliteaucubigenin. Concurrently, using cell models, molecular biology techniques, and animal models, we systematically elucidate its specificsignaling pathways and molecular targets(e.g., Nrf2/HO-1, NF-κB, MAPK, TGF-β1/Smad, RANKL/RANK/OPG, Wnt/β-catenin) in areas such asantioxidant, anti-inflammatory, hepatoprotective, anti-osteoporotic, and neuroprotectiveeffects, providing our clients with solid mechanism-basedscientific evidence for product development and efficacy claims.

• 专业的稳定性与制剂解决方案：

• 针对桃叶珊瑚甙及其甙元对光、热、pH敏感 的稳定性挑战，我们提供全程避光、低温、惰性气体保护 的生产和包装方案。对于高纯度单体，我们采用棕色玻璃瓶充氮密封 包装。同时，我们掌握磷脂复合物、环糊精包合、固体分散体、纳米乳、脂质体 等先进的制剂技术，可大幅提高桃叶珊瑚甙的脂溶性/水溶性、胃肠稳定性、生物膜通透性和生物利用度，为其在口服液、软胶囊、注射剂、透皮制剂、化妆品 等不同剂型中的应用提供技术支持。

• Addressing the stability challenges of aucubin and its aglycone—sensitivity to light, heat, pH—we provide production and packaging solutions featuring complete light protection, low temperature, inert gas protection. For high-purity monomers, we useamber glass bottles with nitrogen flushing and sealing. Furthermore, we master advanced formulation technologies such as phospholipid complexation, cyclodextrin inclusion, solid dispersion, nanoemulsion, liposome, which can significantly improve thelipophilicity/water solubility, gastrointestinal stability, biomembrane permeability, and bioavailabilityof aucubin, providing technical support for its application in various dosage forms like oral liquids, softgels, injectables, transdermal preparations, cosmetics.

联系我们 | Contact Us

• 公司： 长沙上禾生物科技有限公司

• Company: Changsha Sunho Bio-Tech Co., Ltd.

• 地址： 中国湖南省长沙市高新技术产业开发区...

• Address: High-tech Industrial Development Zone, Changsha, Hunan Province, China...

•