长沙上禾生物科技有限公司 | Changsha Sunho Bio-Tech Co., Ltd.

公司简介 | Company Profile

长沙上禾生物科技有限公司是一家专注于天然活性成分与医药中间体研发、生产、销售的国家高新技术企业。我们深度聚焦于具有明确药理作用和广阔市场前景的植物源化合物，通过现代化提取分离技术和绿色生产工艺，为全球健康产业提供标准化的高纯度产品。公司拥有先进的研发实验室、符合cGMP、ISO22000、HALAL、KOSHER等国际标准的生产车间，建立了从原料种植、工艺开发、质量控制到应用研究的完整产业体系。我们以“科学循证，品质卓越”为核心理念，致力于成为全球客户在功能原料和医药中间体领域最可靠的合作伙伴。

Changsha Sunho Bio-Tech Co., Ltd. is a national high-tech enterprise specializing in the R&D, production, and sales of natural active ingredients and pharmaceutical intermediates. We deeply focus on plant-derived compounds with clear pharmacological effects and broad market prospects, providing standardized, high-purity products to the global health industry through modern extraction and separation technologies and green production processes. The company possesses advanced R&D laboratories, production workshops compliant with international standards such as cGMP, ISO22000, HALAL, and KOSHER, and has established a complete industrial system encompassing raw material cultivation, process development, quality control, and application research. Adhering to the core philosophy of "Scientific Evidence, Exceptional Quality," we are committed to becoming the most reliable partner for global clients in the fields of functional ingredients and pharmaceutical intermediates.

主打产品：盐酸黄连素（盐酸小檗碱）| Key Product: Berberine Hydrochloride

产品概览 | Product Overview

盐酸黄连素，即盐酸小檗碱，是一种从传统药用植物（如黄连、黄柏、三颗针、白毛茛）中提取的季铵型异喹啉类生物碱，是小檗碱 的盐酸盐形式。作为中国药典收录的经典药物成分，其应用历史悠久。现代药理学研究已将其从单纯的“止泻抗菌药”重新定义为一种具有多靶点、多通路 调节作用的“代谢调节剂”。其核心作用机制与激活腺苷酸活化蛋白激酶 密切相关，能显著改善胰岛素抵抗、调节糖脂代谢、减轻慢性炎症、调节肠道菌群、保护心血管，在2型糖尿病、代谢综合征、非酒精性脂肪肝、高脂血症、多囊卵巢综合征 等慢性代谢性疾病的辅助管理中展现出卓越潜力，被誉为“天然二甲双胍”。我们的盐酸黄连素系列产品，涵盖从医药级、食品级到高纯度标准品 的全线规格，以其高纯度、高稳定性、优异的生物利用度解决方案 而著称。

Berberine Hydrochloride, the hydrochloride salt of berberine, is aquaternary ammonium isoquinoline alkaloidextracted from traditional medicinal plants such as Coptis chinensis, Phellodendron amurense, Berberis species, Hydrastis canadensis. As a classic drug ingredient included in the Chinese Pharmacopoeia, it has a long history of application. Modern pharmacological research has redefined it from a simple "antidiarrheal and antibacterial agent" to a "metabolic modulator" withmulti-target, multi-pathwayregulatory effects. Its core mechanism of action is closely related to the activation of AMP-activated protein kinase, significantly improvinginsulin resistance, regulating glucose and lipid metabolism, alleviating chronic inflammation, modulating gut microbiota, and protecting the cardiovascular system. It demonstrates outstanding potential in the adjunctive management of chronic metabolic diseases such as type 2 diabetes, metabolic syndrome, non-alcoholic fatty liver disease, hyperlipidemia, and polycystic ovary syndrome, and is hailed as a "natural metformin." Our berberine hydrochloride product series covers the full range of specifications frompharmaceutical grade, food grade, to high-purity standards, renowned for their *high purity, high stability, and excellent bioavailability solutions.

核心药理与功效 | Core Pharmacology & Efficacy

1. 强大的降血糖与改善胰岛素抵抗作用 | Potent Hypoglycemic Effect & Improvement of Insulin Resistance

• 激活AMPK通路： 盐酸黄连素是腺苷酸活化蛋白激酶 的经典激活剂。激活AMPK可：

  
  

• *Activation of AMPK Pathway: Berberine hydrochloride is a classic activator of AMP-activated protein kinase. AMPK activation can:

  
  

• 增加骨骼肌、肝脏、脂肪组织 对葡萄糖的摄取和利用。

  
  

• *Increase glucose uptake and utilization in skeletal muscle, liver, adipose tissue.

  
  

• 抑制肝脏糖原分解 和糖异生，减少肝糖输出。

  
  

• *Inhibit hepatic *glycogenolysisand gluconeogenesis, reducing hepatic glucose output.

  
  

• 促进脂肪酸氧化，改善脂质代谢紊乱。

  
  

• *Promote fatty acid oxidation, improving lipid metabolism disorders.

  
  

• 调节胰岛素信号通路： 改善胰岛素受体底物-1/磷脂酰肌醇3-激酶/蛋白激酶B 信号传导，增强外周组织对胰岛素的敏感性。

  
  

• *Modulation of Insulin Signaling Pathway: Improves insulin receptor substrate-1/phosphatidylinositol 3-kinase/protein kinase Bsignal transduction, enhancing insulin sensitivity in peripheral tissues.

  
  

• 抑制肠道α-葡萄糖苷酶： 延缓碳水化合物在肠道的消化吸收，降低餐后血糖峰值。

  
  

• Inhibition of Intestinal α-glucosidase: Delays carbohydrate digestion and absorption in the intestine, lowering postprandial blood glucose peaks.

  
  

• 促进胰高血糖素样肽-1分泌： 通过激活肠内分泌L细胞上的苦味受体TAS2R，促进胰高血糖素样肽-1 分泌，进而刺激胰岛素分泌、抑制胰高血糖素分泌、延缓胃排空。

  
  

• *Promotion of GLP-1 Secretion: Promotes *glucagon-like peptide-1secretion by activating the bitter taste receptor TAS2R on intestinal endocrine L cells, thereby stimulating insulin secretion, inhibiting glucagon secretion, and delaying gastric emptying.

  
  

2. 综合调节血脂与改善非酒精性脂肪肝 | Comprehensive Lipid Regulation & Improvement of NAFLD

• 降低血清总胆固醇、低密度脂蛋白胆固醇、甘油三酯： 通过上调肝脏低密度脂蛋白受体 表达，促进低密度脂蛋白 清除；抑制脂肪合成 相关酶（如乙酰辅酶A羧化酶、脂肪酸合酶）的活性。

  
  

• *Lowers Serum TC, LDL-C, TG: Upregulates hepatic LDL receptorexpression, promotingLDLclearance; inhibits the activity of enzymes involved in *fat synthesis(e.g., acetyl-CoA carboxylase, fatty acid synthase).

  
  

• 升高高密度脂蛋白胆固醇： 可能通过促进载脂蛋白A-I 合成实现。

  
  

• *Raises HDL-C: Possibly achieved by promoting apolipoprotein A-Isynthesis.

  
  

• 改善非酒精性脂肪肝： 通过AMPK激活，抑制肝脏脂肪生成，促进脂肪酸β氧化；减轻肝脏氧化应激 和内质网应激；抑制肝星状细胞 活化，抗肝纤维化。

  
  

• *Improves NAFLD: Through AMPK activation, inhibits hepaticlipogenesis, promotes fatty acid β-oxidation; alleviates hepaticoxidative stressand endoplasmic reticulum stress; inhibits hepaticstellate cellactivation, exerting anti-fibroticeffects.

  
  

3. 心血管保护与抗动脉粥样硬化 | Cardiovascular Protection & Anti-atherosclerosis

• 改善内皮功能： 通过AMPK/内皮型一氧化氮合酶 通路促进一氧化氮 生成，舒张血管，改善血流。

  
  

• *Improves Endothelial Function: Promotes *nitric oxideproduction via the AMPK/eNOSpathway, dilating blood vessels and improving blood flow.

  
  

• 抗动脉粥样硬化： 抑制血管平滑肌细胞 增殖和迁移；减少单核细胞 黏附于血管内皮；抑制泡沫细胞形成；具有抗氧化、抗炎 作用，稳定斑块。

  
  

• *Anti-atherosclerosis: Inhibits proliferation and migration of vascular smooth muscle cells; reducesmonocyteadhesion to vascular endothelium; inhibits foam cell formation; exerts antioxidant, anti-inflammatoryeffects, stabilizing plaques.

  
  

4. 调节肠道菌群与抗炎 | Modulation of Gut Microbiota & Anti-inflammation

• 重塑肠道菌群结构： 抑制潜在有害菌（如大肠杆菌、肠球菌），促进有益菌（如双歧杆菌、乳酸杆菌、阿克曼氏菌、产丁酸菌）生长，从而改善肠道屏障功能，减少内毒素 入血。

  
  

• *Remodels Gut Microbiota Structure: Inhibits potentially harmful bacteria (e.g., Escherichia coli, Enterococcus), promotes the growth of beneficial bacteria (e.g.,Bifidobacterium, Lactobacillus, Akkermansia, butyrate-producing bacteria), thereby improving intestinal barrier function and reducing endotoxinentry into the bloodstream.

  
  

• 全身性抗炎： 通过调节肠道菌群，减少促炎因子产生；同时直接抑制核因子-κB、丝裂原活化蛋白激酶 等炎症信号通路，降低肿瘤坏死因子-α、白细胞介素-6、白细胞介素-1β 等水平，减轻慢性低度炎症。

  
  

• *Systemic Anti-inflammation: By modulating gut microbiota, reduces production of pro-inflammatory factors; concurrently directly inhibits inflammatory signaling pathways like NF-κB, MAPK, lowering levels ofTNF-α, IL-6, IL-1β, alleviating chronic low-grade inflammation.

  
  

5. 其他重要活性 | Other Important Activities

• 抗心律失常： 通过延长心肌细胞动作电位时程，抑制钾、钙离子通道，对多种实验性心律失常有对抗作用。

  
  

• *Anti-arrhythmic: Acts against various experimental arrhythmias by prolonging the action potential duration of cardiomyocytes and inhibiting potassium and calcium ion channels.

  
  

• 神经保护： 对阿尔茨海默病、帕金森病、脑缺血 等模型具有保护作用，机制涉及抗氧化、抗炎、抗凋亡、抑制乙酰胆碱酯酶、减少β-淀粉样蛋白沉积 等。

  
  

• *Neuroprotective: Exerts protective effects in models of *Alzheimer's disease, Parkinson's disease, cerebral ischemia, involving mechanisms such as antioxidant, anti-inflammatory, anti-apoptotic, acetylcholinesterase inhibition, reduction of beta-amyloid deposition.

  
  

• 抗肿瘤： 对多种肿瘤细胞有抑制作用，机制包括诱导细胞周期阻滞、促进凋亡、抑制转移、调节肿瘤微环境 等。

  
  

• *Anti-tumor: Inhibits various tumor cells through mechanisms including inducing cell cycle arrest, promoting apoptosis, inhibiting metastasis, modulating tumor microenvironment.

  
  

产品规格系列 | Product Specifications Series

通用质量标准 (以医药级98%盐酸小檗碱为例) | General Quality Standards (Example for Pharmaceutical Grade 98% Berberine HCl)

• 外观： 亮黄色或橙黄色结晶性粉末。

  
  

• Appearance: Bright yellow or orange-yellow crystalline powder.

  
  

• 鉴别： (1) 化学反应（生物碱沉淀反应）；(2) 紫外光谱；(3) 红外光谱；(4) HPLC与对照品保留时间一致。

  
  

• Identification: (1) Chemical reaction (alkaloid precipitation); (2) UV spectrum; (3) IR spectrum; (4) HPLC retention time consistent with reference standard.

  
  

• 含量 (HPLC)： 按干燥品计，含盐酸小檗碱 ≥ 98.0%。

  
  

• Assay (HPLC): Calculated on the dried basis, contains berberine hydrochloride ≥ 98.0%.

  
  

• 干燥失重： ≤ 12.0% (中国药典) 或按客户要求 ≤ 5.0%。

  
  

• Loss on Drying: ≤ 12.0% (ChP) or as per customer requirement ≤ 5.0%.

  
  

• 炽灼残渣： ≤ 0.2%。

  
  

• Residue on Ignition: ≤ 0.2%.

  
  

• 重金属： ≤ 20 mg/kg。

  
  

• Heavy Metals: ≤ 20 mg/kg.

  
  

• 有关物质 (HPLC)： 单一杂质 ≤ 0.5%，总杂质 ≤ 2.0% (或符合药典/客户标准)。

  
  

• Related Substances (HPLC): Single impurity ≤ 0.5%, total impurities ≤ 2.0% (or complies with pharmacopoeia/customer standard).

  
  

• 微生物限度： 需氧菌总数 ≤ 1000 CFU/g，霉菌和酵母菌总数 ≤ 100 CFU/g，不得检出大肠埃希菌、沙门氏菌。

  
  

• Microbial Limits: Total aerobic microbial count ≤ 1000 CFU/g, total combined yeasts and molds count ≤ 100 CFU/g, Escherichia coli and Salmonella not detected.

  
  

包装与储存 | Packaging & Storage

• 包装：

  
  

• 医药/食品级： 1kg/铝箔袋，5kg/铝箔袋，10kg/纸板桶，25kg/纸板桶。内袋密封防潮。

  
  

• Pharmaceutical/Food Grade: 1kg/aluminum foil bag, 5kg/aluminum foil bag, 10kg/paper drum, 25kg/paper drum. Inner bag sealed, moisture-proof.

  
  

• 标准品/高纯度： 100mg, 250mg, 500mg, 1g, 5g, 10g/棕色玻璃瓶，内附干燥剂，密封。

  
  

• Standard/High Purity: 100mg, 250mg, 500mg, 1g, 5g, 10g/amber glass bottle, with desiccant, sealed.

  
  

• 储存： 密封，置于阴凉、干燥、避光 处，常温保存。保持容器密闭以防吸湿。在规定的储存条件下，保质期一般为36个月。

  
  

• *Storage: Store in a sealed container in a *cool, dry, darkplace at room temperature. Keep container tightly closed to prevent moisture absorption. Under specified storage conditions, shelf life is typically 36 months.

  
  

主要应用领域 | Primary Application Areas

• 药品：

  
  

• 化学药/中成药： 作为止泻药、抗菌药，用于胃肠道感染、细菌性痢疾。作为降血糖、调血脂药，用于2型糖尿病、高脂血症 的辅助治疗（需在医生指导下使用）。

  
  

• *Chemical Drugs/Traditional Chinese Patent Medicines: As an antidiarrheal, antibacterial agentforgastrointestinal infections, bacterial dysentery. As a *hypoglycemic, lipid-regulating drugfor adjunctive treatment of type 2 diabetes, hyperlipidemia(under medical guidance).

  
  

• 膳食补充剂与保健食品：

  
  

• 血糖与代谢健康： 用于辅助调节血糖、改善胰岛素抵抗、管理体重、改善多囊卵巢综合征相关代谢问题 的胶囊、片剂。

  
  

• *Blood Sugar & Metabolic Health: Used in *capsules, tabletsfor assisting in blood sugar regulation, improving insulin resistance, weight management, improving PCOS-related metabolic issues.

  
  

• 心血管健康： 用于辅助降低总胆固醇、低密度脂蛋白胆固醇、甘油三酯，支持心血管整体功能 的补充剂。

  
  

• *Cardiovascular Health: Used in supplements for assisting in lowering total cholesterol, LDL-C, triglycerides, and supporting overall cardiovascular function.

  
  

• 肠道健康： 利用其调节肠道菌群和轻度抗菌作用，用于改善肠道菌群平衡、支持消化健康 的产品。

  
  

• *Gut Health: Leveraging its gut microbiota modulating and mild antibacterial effects, used in products for improving gut microbiota balance, supporting digestive health.

  
  

• 功能性食品： 可添加于特定功能的固体饮料、代餐粉、功能性糖果 中，但需符合当地法规对添加量和声称的要求。

  
  

• *Functional Foods: Can be added to specific functional solid beverages, meal replacement powders, functional candies, subject to compliance with local regulations on dosage and claims.

  
  

• 兽药与宠物保健： 用于宠物腹泻、肠道感染、代谢问题 的辅助管理。

  
  

• *Veterinary Medicine & Pet Healthcare: Used for adjunctive management of diarrhea, intestinal infections, metabolic issuesin pets.

  
  

• 化妆品（新兴应用）： 利用其抗菌、抗炎、抗氧化 特性，用于控油、祛痘、舒缓 类护肤品。

  
  

• *Cosmetics (Emerging Application): Utilizing its *antibacterial, anti-inflammatory, antioxidantproperties, used in oil-control, acne-fighting, soothingskincare products.

  
  

我们的核心优势 | Our Core Advantages

• 全产业链质控与绿色工艺：

  
  

• 源头把控： 我们与黄连、黄柏 的GAP种植基地建立战略合作，从源头确保原料的品种纯正、无重金属/农残污染、有效成分含量稳定。

  
  

• *Source Control: We establish strategic partnerships with GAP cultivation bases for *Coptis chinensis, Phellodendron amurense, ensuring from the source that raw materials are of authentic variety, free from heavy metal/pesticide contamination, and have stable active component content.

  
  

• 绿色高效提取： 采用酸碱法、树脂法、膜分离 等组合工艺进行提取纯化，优化溶剂使用和回收系统，实现高收率、高纯度、低溶剂残留、环境友好 的生产。

  
  

• *Green & Efficient Extraction: Employing combined processes such as *acid-base method, resin method, membrane separationfor extraction and purification, optimizing solvent use and recovery systems to achieve production that is high-yield, high-purity, low solvent residue, and environmentally friendly.

  
  

• 专业的生物利用度提升技术：

  
  

• 我们深知普通盐酸黄连素口服生物利用度低（通常<5%）是其主要应用瓶颈。为此，我们开发了多种成熟的生物利用度增强技术平台：

  
  

• *We are well aware that the low oral bioavailability of conventional berberine hydrochloride (typically<5%) is its main application bottleneck. Therefore, we have developed several mature Bioavailability Enhancement Technology Platforms:

  
  

• 磷脂复合物技术： 显著提高脂溶性和细胞膜透过性。

  
  

• *Phospholipid Complex Technology: Significantly improves lipophilicity and cell membrane permeability.

  
  

• 固体分散体技术： 将药物高度分散于水溶性载体中，极大提高溶解速率和溶出度。

  
  

• *Solid Dispersion Technology: Highly disperses the drug in water-soluble carriers, greatly improving dissolution rate and solubility.

  
  

• 纳米晶体技术： 减小药物颗粒至纳米级，大幅增加比表面积，加速溶解和吸收。

  
  

• *Nanocrystal Technology: Reduces drug particles to the nanoscale, vastly increasing specific surface area, accelerating dissolution and absorption.

  
  

• 自微乳系统： 在胃肠道中自发形成微乳，促进淋巴吸收，提高生物利用度。

  
  

• *Self-microemulsifying Drug Delivery System: Forms microemulsions spontaneously in the gastrointestinal tract, promoting lymphatic absorptionand enhancing bioavailability.

  
  

• 全面的科学支持与法规服务：

  
  

• 循证资料库： 我们持续跟踪全球关于黄连素的最新临床研究、作用机制、剂量效应关系、药物相互作用、安全性 的科学文献，为客户提供专业的产品开发、配方设计、功效声称 的科学依据。

  
  

• *Evidence-based Database: We continuously track global scientific literature on the latest *clinical research, mechanisms of action, dose-effect relationships, drug interactions, safetyof berberine, providing clients with professional scientific basis for product development, formulation design, efficacy claims.

  
  

• 法规合规指导： 我们熟悉中国、美国、欧盟、日本等主要市场对黄连素 作为药品、膳食补充剂、新食品原料、化妆品原料 的不同法规要求，能为客户提供合规性咨询，帮助产品顺利进入目标市场。

  
  

• *Regulatory Compliance Guidance: We are familiar with the different regulatory requirements for *berberineas a drug, dietary supplement, novel food ingredient, cosmetic ingredientin key markets like China, USA, EU, Japan, and can provide compliance consulting to assist clients in successfully entering target markets.

  
  

重要安全提示 | Important Safety Notice

• 盐酸黄连素具有明确的药理活性，不可随意超量服用。长期或大剂量使用应在医生或专业人员指导下进行。

  
  

• *Berberine hydrochloride has definite pharmacological activity and should not be taken in excess arbitrarily. Long-term or high-dose use should be under the guidance of a doctor or professional.

  
  

• 可能影响肝脏药物代谢酶CYP450，与某些药物（如他汀类、钙通道阻滞剂、环孢素、地高辛、华法林 等）存在相互作用风险，合用需谨慎。

  
  

• *May affect *hepatic drug-metabolizing enzyme CYP450, posing a risk of interaction with certain drugs (e.g., statins, calcium channel blockers, cyclosporine, digoxin, warfarin, etc.). Caution is advised when co-administering.

  
  

• 孕妇、哺乳期妇女、婴幼儿、严重肝肾功能不全者慎用。

  
  

• Use with caution in pregnant women, lactating women, infants, and individuals with severe liver or kidney dysfunction.

  
  

联系我们 | Contact Us

• 公司： 长沙上禾生物科技有限公司

  
  

• Company: Changsha Sunho Bio-Tech Co., Ltd.

  
  

• 地址： 中国湖南省长沙市高新技术产业开发区...

  
  

• Address: High-tech Industrial Development Zone, Changsha, Hunan Province, China...

  
  

•