长沙上禾生物科技有限公司 | Changsha Sunho Bio-Tech Co., Ltd.

公司简介 | Company Profile

长沙上禾生物科技有限公司是一家专注于高活性天然产物的研发、生产和销售的国家高新技术企业。我们聚焦于具有显著生物学活性和明确临床价值的植物来源化合物，致力于通过现代分离纯化技术和绿色工艺，为全球制药、功能食品、化妆品及科研机构提供标准化的优质原料。公司拥有符合cGMP、ISO22000、HALAL、KOSHER等国际标准的生产体系，建立了从植物资源选育、工艺开发、规模化生产到质量控制的完整产业链。我们以创新驱动发展，以科学保障品质，致力于成为全球客户在天然活性成分领域最可信赖的合作伙伴。

Changsha Sunho Bio-Tech Co., Ltd. is a national high-tech enterprise specializing in the R&D, production, and sales of highly active natural products. We focus on plant-derived compounds with significant biological activity and clear clinical value, committed to providing standardized, high-quality raw materials to the global pharmaceutical, functional food, cosmetic, and scientific research sectors through modern separation and purification technologies and green processes. The company operates a production system compliant with international standards such as cGMP, ISO22000, HALAL, and KOSHER, and has established a complete industry chain from plant resource selection and breeding, process development, and large-scale production to quality control. Driven by innovation and grounded in science to ensure quality, we are dedicated to becoming the most trustworthy partner for global clients in the field of natural active ingredients.

主打产品：积雪草酸 | Key Product: Asiatic Acid

产品概览 | Product Overview

积雪草酸 是一种从传统药用植物积雪草 中分离得到的五环三萜酸 类化合物，是积雪草发挥核心药理活性的关键苷元。积雪草在亚洲传统医学中应用历史悠久，被誉为“智慧之草”，常用于促进伤口愈合、治疗皮肤疾病和改善认知功能。积雪草酸是其相关三萜皂苷（如积雪草苷、羟基积雪草苷）在体内的主要活性代谢产物，其生物活性通常更强、更直接。现代药理学研究证实，积雪草酸具有促进成纤维细胞增殖与胶原合成、强效抗炎、抗氧化、抗凋亡、神经保护、抗纤维化、抗肿瘤 等多重生物活性，尤其在对皮肤、神经、肝脏、肺脏 等组织的损伤修复与功能保护 方面表现卓越，是开发高端皮肤修复产品、神经保护药物、抗纤维化药物及抗衰老产品 的明星成分。

Asiatic Acidis a pentacyclic triterpenoid acidisolated from the traditional medicinal plantCentella asiatica(Gotu Kola), and is the key aglyconeresponsible for the core pharmacological activities of Centella asiatica. Centella asiatica has a long history of use in traditional Asian medicine, known as the "herb of wisdom," commonly used to promote wound healing, treat skin disorders, and improve cognitive function. Asiatic acid is theprimary active metaboliteof its related triterpenoid saponins (such as asiaticoside and madecassoside) in the body, and its biological activity is typically stronger and more direct. Modern pharmacological research confirms that asiatic acid possesses multiple biological activities includingpromoting fibroblast proliferation and collagen synthesis, potent anti-inflammatory, antioxidant, anti-apoptotic, neuroprotective, anti-fibrotic, and anti-tumoreffects. It demonstrates exceptional performance, particularly in the injury repair and functional protectionof tissues such as theskin, nerves, liver, and lungs, making it a star ingredient for developing *high-end skin repair products, neuroprotective drugs, anti-fibrotic agents, and anti-aging products.

核心药理与功效 | Core Pharmacology & Efficacy

1. 卓越的皮肤修复与抗衰老作用 | Outstanding Skin Repair & Anti-aging Effects

• 促进伤口愈合：

• 通过上调I型和III型胶原、纤维连接蛋白、弹性蛋白 的基因表达与蛋白合成，促进细胞外基质 重建。

• *Promotes the gene expression and protein synthesis of *type I and III collagen, fibronectin, elastin, facilitating extracellular matrixremodeling.

• 刺激成纤维细胞、角质形成细胞、血管内皮细胞 的增殖、迁移和分化，加速肉芽组织形成、再上皮化和血管新生。

• *Stimulates the proliferation, migration, and differentiation of *fibroblasts, keratinocytes, vascular endothelial cells, accelerating granulation tissue formation, re-epithelialization, and angiogenesis.

• 对烧伤、手术切口、慢性溃疡、糖尿病足溃疡 等多种急慢性伤口模型均显示出显著的治疗效果。

• *Shows significant therapeutic effects on various acute and chronic wound models such as burns, surgical incisions, chronic ulcers, diabetic foot ulcers.

• 抗光老化和抗皱纹：

• 抑制紫外线 诱导的基质金属蛋白酶-1, -3, -9 的过度表达，保护皮肤胶原蛋白和弹性纤维 免受降解。

• *Inhibits UV-induced overexpression of *matrix metalloproteinases (MMP-1, -3, -9), protecting skin collagen and elastic fibersfrom degradation.

• 通过激活转化生长因子-β/Smad 和磷脂酰肌醇3-激酶/蛋白激酶B 通路，持续促进胶原合成，增加皮肤厚度和弹性。

• *Continuously promotes collagen synthesis by activating the *transforming growth factor-β/Smadand phosphatidylinositol 3-kinase/protein kinase Bpathways, increasing skin thickness and elasticity.

• 有效减轻光老化引起的皱纹、皮肤粗糙和色素沉着。

• *Effectively reduces wrinkles, skin roughness, and pigmentationcaused by photoaging.

• 抗炎与抗氧化：

• 强效抑制核因子-κB、丝裂原活化蛋白激酶 等炎症信号通路，减少肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6、前列腺素E2、一氧化氮 等炎症介质的产生。

• *Potently inhibits inflammatory signaling pathways such as *nuclear factor-kappa B, mitogen-activated protein kinase, reducing the production of inflammatory mediators like tumor necrosis factor-alpha, interleukin-1β, interleukin-6, prostaglandin E2, nitric oxide.

• 清除活性氧，提升超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶 等内源性抗氧化酶活性，保护皮肤细胞免受氧化损伤。

• *Scavenges *reactive oxygen species, enhances the activity of endogenous antioxidant enzymes like superoxide dismutase, glutathione peroxidase, catalase, protecting skin cells from oxidative damage.

2. 显著的神经保护与认知增强作用 | Significant Neuroprotective & Cognitive Enhancement Effects

• 抗阿尔茨海默病：

• 抑制β-淀粉样蛋白 的生成、聚集和毒性，并促进其清除。

• *Inhibits the production, aggregation, and toxicity of beta-amyloid, and promotes its clearance.

• 抑制tau蛋白 的过度磷酸化。

• *Inhibits the hyperphosphorylation of tau protein.

• 减轻神经炎症、氧化应激和线粒体功能障碍，保护神经元免受损伤，改善学习和记忆功能。

• *Alleviates neuroinflammation, oxidative stress, and mitochondrial dysfunction, protecting neurons from damage and improving learning and memory functions.

• 抗脑缺血/再灌注损伤：

• 缩小脑梗死 体积，减轻脑水肿，改善神经功能缺损。

• *Reduces *cerebral infarctvolume, alleviates cerebral edema, and improves neurological deficits.

• 其机制涉及抑制细胞凋亡、减轻炎症、抗氧化、保护血脑屏障 完整性。

• *The mechanisms involve inhibiting apoptosis, reducing inflammation, antioxidation, and protecting the integrity of the blood-brain barrier.

• 抗抑郁与抗焦虑：

• 调节下丘脑-垂体-肾上腺轴 功能，降低皮质醇水平。

• *Modulates the function of the hypothalamic-pituitary-adrenal axis, lowering cortisol levels.

• 增加脑内5-羟色胺、多巴胺、去甲肾上腺素 等单胺类神经递质水平，具有抗抑郁潜力。

• *Increases the levels of monoamine neurotransmitters in the brain such as serotonin, dopamine, norepinephrine, showing antidepressant potential.

3. 强大的抗纤维化与器官保护作用 | Potent Anti-fibrotic & Organ Protective Effects

• 抗肝纤维化：

• 抑制肝星状细胞 的活化、增殖和转化为肌成纤维细胞，减少I型和III型胶原 的过度沉积。

• *Inhibits the activation, proliferation, and transformation of hepatic stellate cellsintomyofibroblasts, reducing excessive deposition of type I and III collagen.

• 通过抑制转化生长因子-β1/Smad 通路，阻断纤维化的关键信号传导。

• *Blocks key fibrotic signaling by inhibiting the transforming growth factor-β1/Smadpathway.

• 抗肺纤维化：

• 在博来霉素、二氧化硅、辐射 诱导的肺纤维化模型中，能减轻肺泡炎、胶原沉积、肺组织结构破坏。

• *In models of pulmonary fibrosis induced by *bleomycin, silica, radiation, it can alleviate alveolitis, collagen deposition, and destruction of lung tissue structure.

• 抗肾纤维化： 在糖尿病肾病、单侧输尿管梗阻 模型中，减轻肾小管间质纤维化，保护肾功能。

• *Anti-renal Fibrosis: In models of diabetic nephropathy, unilateral ureteral obstruction, it alleviates renal tubular interstitial fibrosis and protects renal function.

4. 抗肿瘤活性 | Anti-tumor Activity

• 对多种癌细胞（如肝癌、肺癌、乳腺癌、结肠癌、宫颈癌、神经胶质瘤）具有抑制作用，机制包括：

• *Exerts inhibitory effects on various cancer cells (e.g., liver, lung, breast, colon, cervical cancer, glioma) through mechanisms including:

• 诱导细胞周期阻滞 于G0/G1期或G2/M期。

• *Inducing *cell cycle arrestat the G0/G1 or G2/M phase.

• 通过线粒体途径、死亡受体途径 诱导细胞凋亡。

• *Inducing cell *apoptosisvia the mitochondrial pathway, death receptor pathway.

• 抑制肿瘤细胞侵袭、迁移、血管生成。

• *Inhibiting tumor cell invasion, migration, angiogenesis.

产品规格系列 | Product Specifications Series

通用质量标准 (以积雪草酸95%为例) | General Quality Standards (Example for 95% Asiatic Acid)

• 外观： 白色或类白色结晶性粉末。

• Appearance: White or off-white crystalline powder.

• 鉴别： (1) 化学反应 (Liebermann-Burchard反应等)；(2) 薄层色谱；(3) 高效液相色谱 (保留时间与对照品一致)；(4) 红外光谱。

• Identification: (1) Chemical reactions (e.g., Liebermann-Burchard reaction); (2) TLC; (3) HPLC (retention time consistent with reference standard); (4) IR spectrum.

• 含量 (HPLC)： 积雪草酸 ≥ 95.0%。

• Assay (HPLC): Asiatic Acid ≥ 95.0%.

• 干燥失重： ≤ 1.0%。

• Loss on Drying: ≤ 1.0%.

• 炽灼残渣： ≤ 0.2%。

• Residue on Ignition: ≤ 0.2%.

• 重金属： 铅(Pb) ≤ 5.0 mg/kg, 砷(As) ≤ 3.0 mg/kg, 汞(Hg) ≤ 0.2 mg/kg, 镉(Cd) ≤ 1.0 mg/kg。

• Heavy Metals: Lead (Pb) ≤ 5.0 mg/kg, Arsenic (As) ≤ 3.0 mg/kg, Mercury (Hg) ≤ 0.2 mg/kg, Cadmium (Cd) ≤ 1.0 mg/kg.

• 农药残留： 符合客户指定标准 (如欧盟EC 396/2005)。

• Pesticide Residues: Complies with customer-specified standards (e.g., EU EC 396/2005).

• 微生物： 总需氧菌 ≤ 1000 CFU/g, 霉菌和酵母菌 ≤ 100 CFU/g, 大肠杆菌、沙门氏菌不得检出。

• Microbiology: Total Aerobic Microbial Count ≤ 1000 CFU/g, Total Combined Yeasts and Molds Count ≤ 100 CFU/g, Escherichia coli and Salmonella not detected.

包装与储存 | Packaging & Storage

• 包装：

• 1kg/铝箔袋，5kg/铝箔袋，10kg/纸板桶，内袋抽真空或充氮保护，密封防潮避光。

• 1kg/aluminum foil bag, 5kg/aluminum foil bag, 10kg/paper drum. Inner bag vacuum-sealed or nitrogen-flushed, sealed, moisture-proof, light-proof.

• 标准品/高纯样品： 10mg, 20mg, 50mg, 100mg, 500mg, 1g/棕色玻璃瓶，内附干燥剂，密封。

• Standard/High Purity Samples: 10mg, 20mg, 50mg, 100mg, 500mg, 1g/amber glass bottle, with desiccant, sealed.

• 储存： 密封，置于阴凉、干燥、避光 处，建议温度2-8°C 冷藏或-20°C 冷冻保存，以长期维持稳定性和活性。在规定的储存条件下，高纯度粉末 保质期一般为24个月，制剂产品 参照具体配方。

• *Storage: Store in a sealed container in a cool, dry, darkplace. Refrigeration at2-8°Cor freezing at -20°Cis recommended for long-term stability and activity maintenance. Under specified storage conditions, shelf life forhigh-purity powderis typically *24 months; for formulated products, refer to the specific formulation.

主要应用领域 | Primary Application Areas

• 高端化妆品与个人护理：

• 抗衰老与抗皱： 用于精华、面霜、眼霜、面膜，促进胶原蛋白和弹性蛋白合成，减少皱纹、紧致肌肤、改善皮肤弹性。

• *Anti-aging & Anti-wrinkle: Used in *serums, creams, eye creams, masksto promote collagen and elastin synthesis, reduce wrinkles, firm skin, improve skin elasticity.

• 皮肤屏障修复与舒缓： 用于敏感肌护理、修复霜、术后护理产品、婴儿护肤，减轻皮肤炎症、红肿、刺激，加速屏障修复。

• *Skin Barrier Repair & Soothing: Used in *sensitive skin care, repair creams, post-procedure care, baby skincareto reduce skin inflammation, redness, irritation, accelerate barrier repair.

• 疤痕管理与伤口护理： 用于疤痕膏、凝胶、医用敷料、烧伤护理产品，抑制疤痕增生（瘢痕疙瘩），促进正常皮肤组织再生。

• *Scar Management & Wound Care: Used in *scar gels, creams, medical dressings, burn care productsto inhibit hypertrophic scar/keloid formation, promote normal skin tissue regeneration.

• 抗光老化： 用于日间防护、防晒产品，抵抗紫外线损伤，预防光老化。

• *Anti-photoaging: Used in *daytime protection, sunscreen productsto resist UV damage, prevent photoaging.

• 药品与医药研发：

• 皮肤科用药： 开发用于烧伤、创伤、手术切口、慢性溃疡、压疮、疤痕 治疗的乳膏、凝胶、喷雾、敷料。

• *Dermatological Drugs: Developing *creams, gels, sprays, dressingsfor treating burns, wounds, surgical incisions, chronic ulcers, pressure sores, scars.

• 神经系统药物： 作为候选药物，用于阿尔茨海默病、帕金森病、脑卒中、抑郁症、神经性疼痛 等疾病的治疗或辅助治疗。

• *Neurological Drugs: As a candidate drug for treating or adjunctive therapy of diseases such as Alzheimer's disease, Parkinson's disease, stroke, depression, neuropathic pain.

• 抗纤维化药物： 开发用于肝纤维化、肺纤维化、肾纤维化 的抗纤维化新药。

• *Anti-fibrotic Drugs: Developing new anti-fibrotic drugs for liver fibrosis, pulmonary fibrosis, renal fibrosis.

• 膳食补充剂与保健食品：

• 口服美容： 用于改善皮肤水分、弹性、减少皱纹、促进伤口愈合 的口服美容丸、口服液、粉剂。

• *Oral Beauty: Used in *oral beauty pills, liquids, powdersto improve skin hydration, elasticity, reduce wrinkles, promote wound healing.

• 神经健康： 用于改善记忆力、认知功能、情绪、神经保护 的补充剂。

• *Neuro Health: Used in supplements for improving memory, cognitive function, mood, neuroprotection.

• 关节与结缔组织健康： 利用其促进胶原合成、抗炎 作用，支持关节、肌腱、韧带 健康。

• *Joint & Connective Tissue Health: Leveraging its *collagen synthesis promotion and anti-inflammatoryeffects to support joint, tendon, ligamenthealth.

我们的核心优势 | Our Core Advantages

• 定向富集与高纯度制备技术：

• 积雪草中积雪草酸含量相对较低，且与结构相似的其他三萜酸（如羟基积雪草酸、桦木酸）共存，分离难度大。我们采用靶向酶解转化、高速逆流色谱、制备型高效液相色谱 等先进技术组合。特别地，我们利用生物转化或定向水解 技术，将积雪草中含量更高但活性前体形式的积雪草苷、羟基积雪草苷 高效、专一地转化为积雪草酸，从而实现了高收率、高纯度（可达99%以上）积雪草酸的规模化、经济性生产，为客户降低了使用成本。

• The content of asiatic acid in Centella asiatica is relatively low, and it coexists with other structurally similar triterpenic acids (e.g., madecassic acid, betulinic acid), making separation challenging. We employ a combination of advanced technologies including targeted enzymatic conversion, high-speed counter-current chromatography, preparative HPLC. Specifically, we utilize bioconversion or targeted hydrolysistechnology to efficiently and specifically convert the more abundant but precursor-active forms in Centella asiatica—asiaticoside and madecassoside—into *asiatic acid. This enables the large-scale, cost-effective production of asiatic acid with high yield and high purity (up to >99%), reducing costs for our clients.

• 深度机制研究与功效数据支持：

• 我们不仅提供原料，更建有细胞与分子生物学、皮肤模型、动物模型 等研究平台，对积雪草酸的作用机制进行深入研究。我们可提供其在促进I型和III型胶原合成、抑制MMP-1表达、激活TGF-β/Smad通路、抑制NF-κB炎症通路、保护神经元、抗纤维化 等方面的详实体外和体内实验数据。这些科学数据可直接用于支持客户的产品功效宣称、配方开发、市场推广和专利申请，显著增强产品的科学可信度和市场竞争力。

• *Beyond providing raw materials, we have established research platforms such as cell and molecular biology, skin models, animal modelsfor in-depth study of asiatic acid's mechanisms of action. We can provide detailedin vitro and in vivo experimental dataon its effects in *promoting type I and III collagen synthesis, inhibiting MMP-1 expression, activating the TGF-β/Smad pathway, inhibiting the NF-κB inflammatory pathway, protecting neurons, and anti-fibrotic activity. This scientific data can be directly used to support our clients' product efficacy claims, formulation development, marketing, and patent applications, significantly enhancing the scientific credibility and market competitiveness of their products.

• 先进的递送系统与配方解决方案：

• 针对积雪草酸水溶性差、皮肤渗透性有限 的挑战，我们开发了多种成熟的促渗与递送技术：

• *Addressing the challenges of asiatic acid's *poor water solubility and limited skin penetration, we have developed several mature penetration enhancement and delivery technologies:

• 脂质体/纳米脂质体： 显著提高皮肤靶向性和透皮吸收率，实现缓释，提高疗效。

• *Liposome/Nanoliposome: Significantly improves skin targeting and transdermal absorption rate, enables sustained release, and enhances efficacy.

• 纳米结构脂质载体/固体脂质纳米粒： 增强皮肤滞留性、稳定性和负载量，适用于各种剂型。

• *Nanostructured Lipid Carriers/Solid Lipid Nanoparticles: Enhances skin retention, stability, and loading capacity, suitable for various dosage forms.

• 微针/透皮贴片： 用于经皮给药，实现精准、可控的递送，尤其适合局部治疗。

• *Microneedles/Transdermal Patches: Used for transdermal drug delivery, achieving precise, controlled delivery, especially suitable for local treatment.

• 口服递送系统： 通过磷脂复合物、自微乳、纳米晶体 等技术，大幅提高其口服生物利用度。

• *Oral Delivery Systems: Technologies like *phospholipid complex, self-microemulsifying, nanocrystalssignificantly improve its oral bioavailability.

联系我们 | Contact Us

• 公司： 长沙上禾生物科技有限公司

• Company: Changsha Sunho Bio-Tech Co., Ltd.

• 地址： 中国湖南省长沙市高新技术产业开发区...

• Address: High-tech Industrial Development Zone, Changsha, Hunan Province, China...

•