长沙上禾生物科技有限公司 | Changsha Sunho Bio-Tech Co., Ltd.

公司简介 | Company Profile

长沙上禾生物科技有限公司是一家专注高纯度天然产物、特色医药中间体与功能性原料的国家高新技术企业。我们以科学为基石，以创新为引擎，深耕植物化学领域，致力于从传统药用植物中挖掘具有明确生物活性和高价值潜力的稀有化合物。公司拥有符合cGMP标准的现代化生产基地、先进的研发实验室和完善的质量控制体系，从原料筛选、工艺开发到规模化生产，实行全流程精益管控。我们始终秉承“专注、专业、卓越、高效”的理念，为全球制药、保健品、化妆品及科研机构提供高品质、标准化的产品与定制化解决方案，是您在天然活性成分领域值得信赖的战略伙伴。

Changsha Sunho Bio-Tech Co., Ltd. is a national high-tech enterprise specializing in high-purity natural products, specialty pharmaceutical intermediates, and functional ingredients. Grounded in science and driven by innovation, we delve deeply into the field of phytochemistry, committed to exploring rare compounds with clear biological activity and high-value potential from traditional medicinal plants. The company boasts a modern production base compliant with cGMP standards, advanced R&D laboratories, and a comprehensive quality control system, implementing lean management throughout the entire process from raw material selection and process development to large-scale production. Adhering to the philosophy of "Focus, Professionalism, Excellence, Efficiency," we provide high-quality, standardized products and customized solutions to the global pharmaceutical, healthcare, cosmetic, and scientific research sectors, serving as your trustworthy strategic partner in the field of natural active ingredients.

主打产品：(-)-牛蒡子苷元 | Key Product: (-)-Arctigenin

产品概览 | Product Overview

(-)-牛蒡子苷元 是一种从传统中药材牛蒡子 中分离得到的木脂素类化合物，是牛蒡子苷在体内的主要活性代谢产物。其化学结构为苯并呋喃型木脂素，天然存在形式为左旋体，具有显著的手性特征，通常其生物活性远高于右旋体或其外消旋混合物。现代药理学研究已全面揭示了(-)-牛蒡子苷元作为一种高效、多靶点天然调节剂 的卓越价值。其最突出的特点在于强大的抗炎、抗病毒、神经保护和抗肿瘤活性，其作用机制核心在于能有效抑制核因子-κB、丝裂原活化蛋白激酶、Janus激酶/信号转导与转录激活因子 等关键促炎信号通路。凭借其良好的脂溶性和血脑屏障通透性，(-)-牛蒡子苷元在自身免疫性疾病、神经退行性疾病、病毒性感染、恶性肿瘤 等重大疾病的预防与治疗领域展现出广阔的开发前景，是当前天然产物研究领域备受瞩目的明星分子。

(-)-Arctigeninis a lignancompound isolated from the traditional Chinese medicinal herbArctii Fructus(Greater Burdock Achene), and is the main active metabolite of arctiin in vivo. Its chemical structure is a benzofuran-type lignan, and its natural form is the levorotatory enantiomer, exhibiting significant chirality. Typically, its biological activity isfar superior to that of the dextrorotatory enantiomer or its racemic mixture. Modern pharmacological research has comprehensively revealed the outstanding value of (-)-arctigenin as a high-potency, multi-target natural modulator. Its most prominent features lie in itspotent anti-inflammatory, antiviral, neuroprotective, and antitumor activities. The core of its mechanism of action is its ability to effectively inhibit key pro-inflammatory signaling pathways such as nuclear factor-kappa B, mitogen-activated protein kinases, and Janus kinase/signal transducer and activator of transcription. Owing to itsgood lipophilicity and blood-brain barrier permeability, (-)-arctigenin demonstrates broad development prospects in the prevention and treatment of major diseases such as *autoimmune diseases, neurodegenerative diseases, viral infections, and malignant tumors, making it a star molecule of great interest in the current field of natural product research.

核心药理与功效 | Core Pharmacology & Efficacy

1. 强大的抗炎与免疫调节作用 | Potent Anti-inflammatory & Immunomodulatory Effects

• 抑制NF-κB信号通路：

• 阻断肿瘤坏死因子-α、白细胞介素-1β、脂多糖 等炎症刺激诱导的核因子-κB 活化，阻止其p65亚基 向细胞核内转位，从而下调多种促炎因子（如TNF-α, IL-6, IL-1β, 前列腺素E2, 诱导型一氧化氮合酶）的基因表达。

• *Blocks the activation of nuclear factor-kappa Binduced by inflammatory stimuli such astumor necrosis factor-alpha, interleukin-1β, lipopolysaccharide, preventing the nuclear translocation of its *p65 subunit, thereby downregulatingthe gene expression of various pro-inflammatory factors (e.g., TNF-α, IL-6, IL-1β, prostaglandin E2, inducible nitric oxide synthase).

• 抑制JAK/STAT信号通路：

• 对Janus激酶/信号转导与转录激活因子 通路，特别是JAK2/STAT3 磷酸化具有显著抑制作用，这是其发挥抗炎、抗肿瘤 作用的关键机制之一。

• *Exerts significant inhibitory effects on the Janus kinase/signal transducer and activator of transcriptionpathway, particularly onJAK2/STAT3phosphorylation, which is one of the key mechanisms for its anti-inflammatory and antitumoractions.

• 调节MAPK通路：

• 抑制细胞外信号调节激酶、c-Jun N末端激酶、p38丝裂原活化蛋白激酶 的磷酸化，减轻炎症和应激反应。

• *Inhibits the phosphorylation of extracellular signal-regulated kinases, c-Jun N-terminal kinases, p38 mitogen-activated protein kinases, alleviating inflammation and stress responses.

• 应用潜力： 对类风湿关节炎、炎症性肠病、哮喘、脓毒症、自身免疫性脑脊髓炎 等多种急慢性炎症和自身免疫性疾病模型具有显著治疗作用。

• *Application Potential: Shows significant therapeutic effects in various acute and chronic inflammation and autoimmune disease models such as rheumatoid arthritis, inflammatory bowel disease, asthma, sepsis, autoimmune encephalomyelitis.

2. 广谱的抗病毒活性 | Broad-Spectrum Antiviral Activity

• 抗流感病毒：

• 通过抑制病毒核蛋白的核输入、干扰病毒RNA聚合酶活性、调节宿主免疫反应 等多种机制，有效抑制甲型流感病毒的复制。

• *Effectively inhibits the replication of influenza A virus through various mechanisms, including inhibiting viral nucleoprotein nuclear import, interfering with viral RNA polymerase activity, and modulating host immune responses.

• 抗人类免疫缺陷病毒： 可抑制人类免疫缺陷病毒 在宿主细胞内的复制。

• *Anti-HIV: Can inhibit the replication of human immunodeficiency virusin host cells.

• 抗乙型肝炎病毒： 在体外可抑制乙型肝炎病毒 DNA的复制和抗原表达。

• *Anti-HBV: Can inhibit the replication of hepatitis B virusDNA and antigen expression in vitro.

• 抗人类巨细胞病毒、单纯疱疹病毒、埃博拉病毒、登革热病毒、新冠病毒 等，展现出广谱抗病毒潜力，其机制多与调节宿主细胞环境、抑制病毒复制关键步骤 有关。

• *Anti-HCMV, HSV, Ebola, Dengue, SARS-CoV-2, etc., demonstrating *broad-spectrum antiviral potential, with mechanisms often related to modulating the host cellular environment and inhibiting key steps in viral replication.

3. 显著的神经保护与抗阿尔茨海默病作用 | Significant Neuroprotective & Anti-Alzheimer's Disease Effects

• 抗神经炎症： 强大的小胶质细胞 抑制作用，减少中枢神经系统内促炎因子的释放，是神经保护 的核心机制。

• *Anti-neuroinflammation: Potent inhibition of *microglia, reducing the release of pro-inflammatory factors in the central nervous system, which is a core mechanism for neuroprotection.

• 抗β-淀粉样蛋白毒性： 减少β-淀粉样蛋白 的生成，促进其清除，并减轻其对神经元的毒性。

• *Anti-amyloid-beta toxicity: Reduces the production of amyloid-beta, promotes its clearance, and alleviates its toxicity to neurons.

• 抗氧化与抗凋亡： 提升细胞内谷胱甘肽 水平，清除活性氧，抑制caspase-3 等凋亡通路，保护神经元免受损伤。

• *Antioxidant & Anti-apoptotic: Increases intracellular glutathionelevels, scavengesreactive oxygen species, inhibits apoptosis pathways such as caspase-3, protecting neurons from damage.

• 改善认知功能： 在阿尔茨海默病动物模型中，可显著改善学习记忆障碍、空间探索能力。

• *Improves cognitive function: In animal models of Alzheimer's disease, it can significantly improve learning and memory deficits, spatial exploration ability.

4. 突出的抗肿瘤作用 | Prominent Antitumor Effects

• 诱导肿瘤细胞凋亡： 通过线粒体途径、死亡受体途径、内质网应激途径 诱导多种癌细胞凋亡。

• *Induces tumor cell apoptosis: Induces apoptosis in various cancer cells via the mitochondrial pathway, death receptor pathway, endoplasmic reticulum stress pathway.

• 抑制肿瘤细胞增殖： 阻滞细胞周期于G1期或G2/M期。

• *Inhibits tumor cell proliferation: Arrests the cell cycle at the G1 or G2/M phase.

• 抑制肿瘤血管生成： 下调血管内皮生长因子 的表达，抑制新生血管形成。

• *Inhibits tumor angiogenesis: Downregulates the expression of vascular endothelial growth factor, inhibiting neovascularization.

• 抑制肿瘤侵袭与转移： 降低基质金属蛋白酶-2, -9 的表达，抑制上皮-间质转化。

• *Inhibits tumor invasion and metastasis: Reduces the expression of matrix metalloproteinase-2, -9, inhibiting epithelial-mesenchymal transition.

• 增敏化疗： 可逆转肿瘤细胞的多药耐药性，增强常规化疗药物的疗效。

• Chemosensitization: Can reverse multidrug resistance in tumor cells, enhancing the efficacy of conventional chemotherapeutic drugs.

• 对肝癌、肺癌、乳腺癌、结肠癌、前列腺癌、胶质母细胞瘤 等均显示出抑制作用。

• *Shows inhibitory effects on cancers such as liver, lung, breast, colon, prostate cancer, glioblastoma, etc.

5. 其他生物活性 | Other Biological Activities

• 保肝作用： 对酒精性肝损伤、化学性肝损伤、肝纤维化 有保护作用，机制涉及抗炎、抗氧化、抑制肝星状细胞活化。

• *Hepatoprotective effect: Protects against *alcoholic liver injury, chemical liver injury, liver fibrosisthrough mechanisms involving anti-inflammation, antioxidation, inhibition of hepatic stellate cell activation.

• 降血糖与改善胰岛素抵抗： 通过激活腺苷酸活化蛋白激酶 通路改善胰岛素敏感性。

• *Hypoglycemic effect & improvement of insulin resistance: Improves insulin sensitivity by activating the AMP-activated protein kinasepathway.

产品规格系列 | Product Specifications Series

通用质量标准 (以(-)-牛蒡子苷元98%为例) | General Quality Standards (Example for 98% (-)-Arctigenin)

• 外观： 白色或类白色结晶性粉末。

• Appearance: White or off-white crystalline powder.

• 鉴别： (1) 薄层色谱 (TLC)；(2) 高效液相色谱 (HPLC， 保留时间与对照品一致)；(3) 红外光谱 (IR)；(4) 质谱 (MS)；(5) 比旋光度。

• Identification: (1) Thin-layer chromatography (TLC); (2) High-performance liquid chromatography (HPLC, retention time consistent with reference standard); (3) Infrared spectroscopy (IR); (4) Mass spectrometry (MS); (5) Specific optical rotation.

• 含量 (HPLC)： (-)-牛蒡子苷元 ≥ 98.0% (按面积归一化法或外标法)。

• Assay (HPLC): (-)-Arctigenin ≥ 98.0% (by area normalization or external standard method).

• 比旋光度： -60° ~ -75° (c = 1, 甲醇)。

• Specific Optical Rotation: -60° ~ -75° (c = 1, Methanol).

• 干燥失重： ≤ 0.5%。

• Loss on Drying: ≤ 0.5%.

• 炽灼残渣： ≤ 0.1%。

• Residue on Ignition: ≤ 0.1%.

• 重金属： 铅(Pb) ≤ 3.0 mg/kg, 砷(As) ≤ 2.0 mg/kg, 汞(Hg) ≤ 0.1 mg/kg, 镉(Cd) ≤ 1.0 mg/kg。

• Heavy Metals: Lead (Pb) ≤ 3.0 mg/kg, Arsenic (As) ≤ 2.0 mg/kg, Mercury (Hg) ≤ 0.1 mg/kg, Cadmium (Cd) ≤ 1.0 mg/kg.

• 手性纯度 (手性HPLC)： (-)-异构体 ≥ 99.0% (或按客户要求)。

• Chiral Purity (Chiral HPLC): (-)-isomer ≥ 99.0% (or as per customer requirements).

• 有关物质 (HPLC)： 单一未知杂质 ≤ 0.5%，总杂质 ≤ 2.0%。

• Related Substances (HPLC): Any single unknown impurity ≤ 0.5%, total impurities ≤ 2.0%.

包装与储存 | Packaging & Storage

• 包装：

• 1g, 5g, 10g, 25g, 50g, 100g/棕色玻璃瓶，内附惰性气体保护和干燥剂，密封，避光。

• 1g, 5g, 10g, 25g, 50g, 100g/amber glass bottle, with inert gas protection and desiccant, sealed, light-proof.

• 大规格 (≥100g)： 100g/铝箔袋，500g/铝箔袋，1kg/铝箔袋，内置于纸板桶或铝罐中，抽真空或充氮。

• Large Specifications (≥100g): 100g/aluminum foil bag, 500g/aluminum foil bag, 1kg/aluminum foil bag, placed inside a paper drum or aluminum can, vacuum-sealed or nitrogen-flushed.

• 储存： 密封，置于-20°C 至 4°C 条件下冷冻或冷藏，严格避光、防潮。由于其对光和热相对敏感，建议长期储存于-20°C。在规定的储存条件下，高纯度产品 保质期一般为24个月，开启后建议尽快使用。

• *Storage: Store in a sealed container at -20°C to 4°C(frozen or refrigerated),strictly protected from light and moisture. Due to its relative sensitivity to light and heat, long-term storage at-20°Cis recommended. Under specified storage conditions, shelf life for *high-purity productsis typically 24 months. Use promptly after opening.

主要应用领域 | Primary Application Areas

• 创新药物与医药研发：

• 抗病毒药物： 开发用于流感、呼吸道合胞病毒感染、新冠病毒感染、乙肝 等的新型抗病毒药物，尤其针对免疫调节型抗病毒策略。

• *Antiviral Drugs: Developing *novel antiviral drugsfor influenza, RSV infection, COVID-19, hepatitis B, etc., especially for immunomodulatory antiviral strategies.

• 抗肿瘤药物： 作为化疗增敏剂、靶向治疗辅助用药、抗转移药物 进行开发，用于肝癌、胶质母细胞瘤、三阴性乳腺癌 等难治性肿瘤。

• *Antitumor Drugs: Developing as *chemosensitizers, adjuvant targeted therapy, anti-metastatic drugsfor refractory tumors such as liver cancer, glioblastoma, triple-negative breast cancer.

• 神经退行性疾病药物： 开发用于阿尔茨海默病、帕金森病、多发性硬化症、肌萎缩侧索硬化 的神经保护剂和疾病修饰剂。

• *Neurodegenerative Disease Drugs: Developing *neuroprotective agents and disease-modifying therapiesfor Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis.

• 自身免疫与抗炎药物： 开发用于类风湿关节炎、炎症性肠病、系统性红斑狼疮、银屑病 等自身免疫性疾病的新型免疫抑制剂/调节剂。

• *Autoimmune & Anti-inflammatory Drugs: Developing *novel immunosuppressants/modulatorsfor autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, psoriasis.

• 高端膳食补充剂与功能性食品：

• 免疫支持： 用于调节过度免疫反应、增强抗病毒能力、维持免疫平衡 的免疫调节 类补充剂。

• *Immune Support: Used in *immunomodulatorysupplements for regulating excessive immune responses, enhancing antiviral capacity, maintaining immune balance.

• 神经健康： 用于改善记忆、认知功能、脑部炎症、情绪支持 的益智、神经保护 类产品。

• *Neuro Health: Used in *nootropic, neuroprotectiveproducts for improving memory, cognitive function, brain inflammation, mood support.

• 肝脏健康： 用于化学性/酒精性肝损伤辅助保护、抗肝纤维化 的护肝 产品。

• *Liver Health: Used in *liver-protectiveproducts for adjunctive protection against chemical/alcoholic liver injury, anti-liver fibrosis.

• 化妆品（前沿应用）：

• 利用其强大的抗炎、抗氧化、抗病毒 特性，开发用于敏感性/炎症性皮肤（如玫瑰痤疮、皮炎）、抗污染、抗光老化、皮肤屏障修复 的高端功能性护肤品。

• *Leveraging its potent anti-inflammatory, antioxidant, antiviralproperties to develophigh-end functional skincarefor sensitive/inflammatory skin (e.g., rosacea, dermatitis), anti-pollution, anti-photoaging, skin barrier repair.

我们的核心优势 | Our Core Advantages

• 高难度手性分离与规模化制备技术：

• (-)-牛蒡子苷元是天然存在的光学活性单体，与(+)-对映体物理化学性质极其相似，手性分离是产业化最大技术瓶颈。我们采用自主研发的高选择性手性固定相制备色谱、模拟移动床色谱、定向酶转化与手性拆分耦合 等核心技术，实现了高光学纯度（对映体过量值 ≥ 99%）的(-)-牛蒡子苷元的公斤级稳定生产，纯度可达99.5%以上，打破了该高价值手性原料依赖昂贵进口或无法规模化的局面，为客户提供了稳定、高质、可控的国产化高端原料。

• *(-)-Arctigenin is a naturally occurring optically active monomer. Its physicochemical properties are extremely similar to its (+)-enantiomer, makingchiral separation the primary technological bottleneck for industrialization. We employ core proprietary technologies such as highly selective chiral stationary phase preparative chromatography, simulated moving bed chromatography, coupled directional enzymatic conversion and chiral resolution. This enables thekilogram-scale stable production of (-)-arctigenin with high optical purity (enantiomeric excess ≥ 99%), achieving purity levels of ≥ 99.5%. This breakthrough overcomes the reliance on expensive imports or the inability to scale production for this high-value chiral raw material, providing our clients with a stable, high-quality, controllable domestic source of premium-grade ingredients.

• 深入的构效关系与机制研究支持：

• 我们不仅提供产品，更建立了基于细胞、类器官、动物模型的完善功能评价平台，专注于(-)-牛蒡子苷元的构效关系、药代动力学、组织分布与核心信号通路 研究。我们可提供详实的科学数据，证明其左旋体相比右旋体在抑制NF-κB、JAK/STAT等通路方面具有显著更高的活性，并阐明其在免疫调节、抗病毒、神经保护、抗肿瘤 等方面的具体分子靶点与作用机制，为新药申报、功能声称、高端产品开发提供坚实的科学依据。

• *Beyond providing products, we have established a comprehensive functional evaluation platform based on cells, organoids, and animal models, focusing on thestructure-activity relationship, pharmacokinetics, tissue distribution, and core signaling pathwaysof (-)-arctigenin. We can provide detailed scientific data demonstrating the *significantly higher activity of the levorotatory enantiomer compared to the dextrorotatory form in inhibiting pathways such as NF-κB and JAK/STAT, and elucidate its specific molecular targets and mechanisms of action in areas like immunomodulation, antiviral activity, neuroprotection, and antitumor effects. This provides solid scientific support for new drug applications, functional claims, and the development of high-end products.

• 定制化的递送与剂型解决方案：

• 针对(-)-牛蒡子苷元水溶性极差、口服吸收有限 的挑战，我们提供从实验室到生产的全方位制剂开发支持。我们的技术包括：

• *Addressing the challenges of (-)-arctigenin's *extremely poor water solubility and limited oral absorption, we provide comprehensive formulation development supportfrom lab to production. Our technologies include:

• 口服生物利用度提升： 磷脂复合物、自微乳、固体分散体、纳米晶体 技术，可将其口服生物利用度提升5-10倍。

• *Oral Bioavailability Enhancement: *Phospholipid complex, self-microemulsifying drug delivery systems, solid dispersions, nanocrystaltechnologies can increase its oral bioavailability by 5-10 times.

• 靶向递送系统： 长循环脂质体、纳米粒、抗体偶联药物前体 技术，实现向肝脏、脑部、肿瘤 等特定组织或细胞的靶向递送。

• *Targeted Delivery Systems: *Long-circulating liposomes, nanoparticles, antibody-drug conjugate precursorsfor targeted delivery to specific tissues or cells such as the liver, brain, tumors.

• 外用透皮制剂： 微乳、脂质体凝胶、微针 技术，提高皮肤渗透性，用于局部抗炎、抗病毒或镇痛应用。

• *Topical/Transdermal Formulations: Microemulsions, liposomal gels, microneedlesto enhance skin permeability for local anti-inflammatory, antiviral, or analgesic applications.

联系我们 | Contact Us

• 公司： 长沙上禾生物科技有限公司

• Company: Changsha Sunho Bio-Tech Co., Ltd.

• 地址： 中国湖南省长沙市高新技术产业开发区...

• Address: High-tech Industrial Development Zone, Changsha, Hunan Province, China...

•