普健生物（武汉）科技有限公司

链接：https://www.abinscience.cn/product/34/15299.html

名称：Anti-HPV16 L2/Minor capsid protein L2 Antibody (MAb24B)

货号：VK658013

种属反应性：Human papillomavirus type (HPV16, HPV18, HPV31, HPV33, HPV35, HPV51, HPV52, HPV58)

宿主：Human

纯度：>95% as determined by SDS-PAGE.

克隆性：Monoclonal

同种型：IgG1, kappa

应用：WB

靶点：Minor capsid protein L2, L2

用途范围：仅用于科研

储存：Use  a manual defrost freezer and avoid repeated freeze-thaw cycles. Store  at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C  long term.

产品介绍：

Anti-HPV16 L2/Minor capsid protein L2 Monoclonal Antibody (MAb24B) 是一种人源化单克隆抗体，由能够特异性识别人乳头瘤病毒16 型次要衣壳蛋白L2 的高变区（VH/VL）与human IgG1 的Fc 片段融合而成。这种结构设计使抗体在结合HPV16 L2 蛋白时兼具高特异性和高亲和力，同时借助IgG1 Fc 片段的稳定性优势，显著提升了Western Blot 等免疫检测实验的灵敏度与重复性。abinScience产品具有亲和力高，灵敏度高，特异性好，稳定性强等优势。

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

The  high risk HPV16 L2 minor capsid protein has multiple transport signals  that mediate its nucleocytoplasmic traffic. PMID: 22154072

The l2 minor capsid protein of human papillomavirus type 16 interacts with a network of nuclear import receptors. PMID: 15507604

Efficient Inhibition of Human Papillomavirus Infection by L2 Minor Capsid-Derived Lipopeptide. PMID: 31387913

Human Papillomavirus Type 16 L2 Gene Sequence Variation Analysis in Indonesian Cervical Cancer Specimens. PMID: 35763643

A  papillomavirus-like particle (VLP) vaccine displaying HPV16 L2 epitopes  induces cross-neutralizing antibodies to HPV11. PMID: 17239496

The evolving field of human papillomavirus receptor research: a review of binding and entry. PMID: 23536685

Factors influencing subcellular localization of the human papillomavirus L2 minor structural protein. PMID: 16257028

HPV16  entry requires dynein for minus-end transport and utilizes kinesin  Kif11 for plus-end transport along microtubules during mitosis. PMID:  39629998

Chimeric  human papillomavirus type 16 (HPV-16) L1 particles presenting the  common neutralizing epitope for the L2 minor capsid protein of HPV-6 and  HPV-16. PMID: 12857908

Cross-neutralization potential of native human papillomavirus N-terminal L2 epitopes. PMID: 21346798

Direct  binding of retromer to human papillomavirus type 16 minor capsid  protein L2 mediates endosome exit during viral infection. PMID: 25693203

The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection. PMID: 22927980

Capsid  display of a conserved human papillomavirus L2 peptide in the  adenovirus 5 hexon protein: a candidate prophylactic hpv vaccine  approach. PMID: 26362430

Chimeric L2-Based Virus-Like Particle (VLP) Vaccines Targeting Cutaneous Human Papillomaviruses (HPV). PMID: 28056100

L2  epitope presenting virus-like particles as broad-spectrum vaccine  candidates targeting genus beta human papillomaviruses. PMID: 41333421

Vesicular  trafficking of incoming human papillomavirus 16 to the Golgi apparatus  and endoplasmic reticulum requires gamma-secretase activity. PMID:  25227470

Inhibition  of Langerhans cell maturation by human papillomavirus type 16: a novel  role for the annexin A2 heterotetramer in immune suppression. PMID:  24719459

Human  Papillomavirus 16 L2 Recruits both Retromer and Retriever Complexes  during Retrograde Trafficking of the Viral Genome to the Cell Nucleus.  PMID: 33177206

Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site. PMID: 28065506

Immunogenic assessment of plant-produced human papillomavirus type 16 L1/L2 chimaeras. PMID: 23924054

Nuclear import strategies of high risk HPV16 L1 major capsid protein. PMID: 11971900

Efficient delivery of DNA vaccines using human papillomavirus pseudovirions. PMID: 20668481

The  cellular endosomal protein stannin inhibits intracellular trafficking  of human papillomavirus during virus entry. PMID: 29058661

A  chimeric 18L1-45RG1 virus-like particle vaccine cross-protects against  oncogenic alpha-7 human papillomavirus types. PMID: 25790098

Broad  Cross-Protection Is Induced in Preclinical Models by a Human  Papillomavirus Vaccine Composed of L1/L2 Chimeric Virus-Like Particles.  PMID: 27147749

Vaccination  with multimeric L2 fusion protein and L1 VLP or capsomeres to broaden  protection against HPV infection. PMID: 20434552

Transient  expression of Human papillomavirus type 16 L2 epitope fused to N- and  C-terminus of coat protein of Potato virus X in plants. PMID: 22357210

Chimeric  papillomavirus virus-like particles elicit antitumor immunity against  the E7 oncoprotein in an HPV16 tumor model. PMID: 9465097

Optimizing a Human Papillomavirus Type 16 L1-Based Chimaeric Gene for Expression in Plants. PMID: 30062095

详情请咨询 abinScience 亚洲区官方子公司 —— 武汉艾必赛生物技术有限公司

官方网址：【中文】https://www.abinscience.cn

 【英文】https://www.abinscience.com

武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。

依托严格的产品研发体系和国际化的质量管理标准，武汉艾必赛与  AtaGenix、ProteoGenix  等知名品牌保持长期战略合作，现已构建起涵盖抗体、重组蛋白、工具酶、试剂盒、实验耗材在内的多品类供应体系，面向区域内科研机构、高校实验室与生物医药企业，提供稳定、高效、可信赖的产品与服务。

核心业务覆盖：

✅ 抗体产品（单抗、多抗、重组抗体等）

✅ 蛋白与多肽试剂（标签蛋白、功能蛋白等）

✅ 分子与细胞实验相关耗材

✅ 定制化研发服务（蛋白表达、抗体定制、亲和力成熟等）

✅ 科研供应链整合与项目配套支持

武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。