Radix Isatidis Extract Indirubin

Product Introduction

A further alkaloid isolated from the matured fruit of Couroupita guianensis, this base forms red crystals from EtOH and melts above 340°C. It forms the Nacetyl derivative, m.p. 186°C. The full structure has not yet been established.

Product Physicochemical Property 

 Dark red acicular crystal with sublimate, odorless, and tasteless. Solubility: slightly soluble in dimethyl sulfoxide (DMSO) or tetrahydrofuran, very slightly soluble in chloroform or acetone, and insoluble in ethanol, ethyl ether, or water. Melting point: 348–353 °C. The stability of indirubin is poor that it needs to be stored away from light and thermal environment.

Product Function

1.  An inhibitor of GSK-3β and cyclin-dependent kinases.

2.  Indigopurpurin is a purple 3,2-bisindole derivative and was shown to exhibit inhibitory allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. A possible glycogen synthase kinase-3 (GSK-3) inhibitor the active component of a traditional Congolese antiepilepsy treatment.

3.  Indirubin could be used for abnormal bone marrow hyperplasia and eosinophilia.

Product Application

1.  Cosmetics,

2.  Food additive

3. Feed additive,

4. Medicine

Charissa Liu

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