Macleaya cordata extract Chelidonine

Product Introduction
Chelidonine, also named ranunculine, is a benzophenanthridine alkaloid. It has been used as a painkiller in clinical treatment based on its morphine-like analgesic effect. Pharmacological researches in recent years have demonstrated that chelidonine played a role in antitumor, antibacterial, spasmolysis activities, and so on. And the antitumor activity is drawing more and more attention. However, its mechanisms of function remain unclear, which needs to be clarified in the future. Chelidonine is an alkaloid fundamental parent, a benzophenanthridine alkaloid and an alkaloid antibiotic. Chelidonine is an isolate of Papaveraceae with acetylcholinesterase and butyrylcholinesterase inhibitory activity 

Product Physicochemical Property 

White crystal or crystalline powder, monoclinic prism crystal. Solubility: insoluble in water; soluble in ethanol, chloroform, and amyl alcohol. Melting point: 135–136 °C. Boiling point: 220 °C. Specific optical rotation: +115°

Product Function

Poison; central nervous system depres- sant causing sleepiness, depression, slowing of the pulse, coma and circulatory failure

1. The effect on nervous system (analgesia, sedation) Chelidonine, as a protopine, has analgesia effect similar to that of morphine. Chelidonine derivatives also have sedative and hypnotic effects .

2. The effect on cardiovascular system Chelidonine has many effects on cardiovascular system, including exciting heart, expanding coronary blood vessels, and increasing blood pressure.

3. The antitumor effect Chelidonine is a toxic substance that can influence mitosis.

4. The effect on smooth muscle Chelidonine has spasmolytic and diastolic effects and can inhibit a variety of smooth muscle spasm. Obvious spasmolytic effects for gastrointestinal tract and bronchial and urinary system have been reported .

5. The antibacterial effect Chelidonine has antibacterial effect. It inhibits Mycobacterium tuberculosis in vivo and inhibits alpha Streptococcus, Diplococcus pneumoniae, and other gram-positive bacteria in vitro. In addition, chelidonine also shows inhibitory effect on Kauffman-Wolf Trichophyta and Epidermophyton floccosum .

6. Other pharmacological effects Chelidonine showed protective effects on cadmium chloride-induced liver and kidney toxicity in rats.

Product Application

1. It can applied in Feed additive

2. It can be applied in Medicine field

3. It can be applied in Veterinary drug

Charissa Liu

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