长沙上禾生物staherb厚朴提取物 Magnolia Bark Extract 核心功效与药理作用中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

中文核心功效与药理作用简介 (Chinese Core Efficacy & Pharmacological Actions)

产品名称：厚朴提取物（Magnolia Bark Extract / 厚朴总酚）

品牌：staherb® 长沙上禾生物

核心活性成分：厚朴酚（Magnolol, CAS 528-43-8）+ 和厚朴酚（Honokiol, CAS 35354-74-6），联苯型新木脂素异构体，C₁₈H₁₈O₂ / 266.33

• 镇静抗焦虑与助眠 (Anxiolytic, Sedative & Sleep Support)：Magnolol 与 Honokiol 均为 GABAₐ 受体正向变构调节剂（Honokiol 脂溶性更高、易透血脑屏障，活性更强），增强 GABA 抑制性神经传导，缓解焦虑样行为、缩短入睡潜伏期，部分研究显示可下调 HPA 轴皮质醇，传统“理气安神”的现代佐证。

• 抗炎与抗过敏 (Anti-inflammatory & Anti-allergic)：抑制 NF-κB / MAPK 信号核转位，下调 TNF-α、IL-1β、IL-6、COX-2、iNOS 等炎症介质；抑制肥大细胞脱颗粒（组胺/β-己糖胺酶释放），对皮炎、口腔牙龈炎等慢性炎症具潜在辅助价值。

• 强效抗氧化 (Potent Antioxidant)：直接清除 DPPH·、·OH、O₂⁻·，激活 Nrf2/ARE 通路上调 SOD、GSH-Px、HO-1，抑制脂质过氧化，保护细胞免受氧化应激损伤，抗光老化与延缓衰老。

• 广谱抗菌与抗幽门螺杆菌 (Broad-spectrum Antimicrobial & Anti-H. pylori)：对金葡菌（含 MRSA）、链球菌、大肠杆菌、白念珠菌、痤疮丙酸杆菌及幽门螺杆菌均有较低 MIC；破坏微生物膜结构，与常规抗菌药联用具增效趋势，是口腔护理与胃肠调理的功能基础。

• 胃肠调理与平滑肌松弛 (GI Regulation & Smooth Muscle Relaxation)：直接拮抗 Ca²⁺ 内流、松弛胃肠/气管/子宫平滑肌，促进胃排空与肠蠕动，改善功能性消化不良、腹胀、肠易激；解释传统“下气除满、消胀满”功效。

• 神经保护 (Neuroprotective)：透 BBB 后抑制小胶质细胞活化与 NLRP3 炎症小体，减少 Aβ 聚集、τ 磷酸化及 α-突触核蛋白毒性，在 AD、PD 及脑缺血再灌注模型中显示认知改善与神经元保护潜力。

• 心血管与代谢调节 (Cardiovascular & Metabolic Support)：轻度抑制 ACE、促进 NO 释放、改善血管内皮与抗动脉粥样硬化；部分研究示降 TC/TG、改善胰岛素信号（GLUT4 转位）及轻度降压趋势。

• 抗肿瘤潜力（研究阶段）(Antitumor Potential, Preclinical)：诱导多种癌细胞（乳腺、前列腺、卵巢、胶质母细胞瘤等）线粒体途径凋亡与 G0/G1、G2/M 周期阻滞，抑制 VEGF 血管生成、MMP 侵袭及 MDR 逆转，仅限细胞/动物研究。

English Core Efficacy & Pharmacological Actions Overview

Product Name: Magnolia Bark Extract (Magnolol & Honokiol / Total Phenols)

Brand: staherb® – Changsha Sunho Biological Co., Ltd.

Active Ingredients: Magnolol (CAS 528-43-8) + Honokiol (CAS 35354-74-6), biphenyl neolignan isomers, C₁₈H₁₈O₂ / 266.33

• Anxiolytic, Sedative & Sleep Support: Both act as positive allosteric modulators of the GABAₐ receptor (Honokiol more lipophilic, BBB-permeable, stronger); enhance GABAergic inhibition, reduce anxiety-like behavior, shorten sleep latency, and some studies show reduced salivary cortisol via HPA-axis modulation—modern basis for traditional “regulating Qi and calming spirit.”

• Anti-inflammatory & Anti-allergic: Suppress NF-κB / MAPK nuclear translocation, downregulate TNF-α, IL-1β, IL-6, COX-2, iNOS; inhibit mast cell degranulation (histamine/β-hexosaminidase), showing potential adjunct value in dermatitis, gingivitis, and chronic mucosal inflammation.

• Potent Antioxidant: Directly scavenge DPPH·, ·OH, O₂⁻·; activate Nrf2/ARE pathway to upregulate SOD, GSH-Px, HO-1, inhibit lipid peroxidation, and protect cells from oxidative stress—supporting anti-photoaging and healthy aging.

• Broad-spectrum Antimicrobial & Anti-H. pylori: Low MIC against S. aureus(incl. MRSA), streptococci, E. coli, C. albicans, P. acnes, and Helicobacter pylori; disrupt microbial membranes, showing synergistic trends with conventional antibiotics—basis for oral care and GI formulations.

• GI Regulation & Smooth Muscle Relaxation: Antagonize Ca²⁺ influx to relax gastric/intestinal/tracheal/uterine smooth muscle, promote gastric emptying and peristalsis, relieve functional dyspepsia, bloating, and IBS—explaining traditional “descending Qi and relieving fullness.”

• Neuroprotective: After crossing BBB, inhibit microglial activation and NLRP3 inflammasome, reduce Aβ aggregation, τ phosphorylation, and α-synuclein toxicity; demonstrate cognitive improvement and neuronal protection in AD, PD, and cerebral ischemia-reperfusion models.

• Cardiovascular & Metabolic Support: Mild ACE inhibition, NO release promotion, endothelial improvement, anti-atherosclerosis; some preclinical data show lowered TC/TG, improved insulin signaling (GLUT4 translocation), and mild antihypertensive trends.

• Antitumor Potential (Preclinical): Induce mitochondrial apoptosis and G0/G1 or G2/M arrest in breast/prostate/ovarian/glioblastoma cells; inhibit VEGF angiogenesis, MMP invasion, and reverse MDR—in vitro/animal stage only.

注 / Note：以上药理作用主要基于细胞、动物实验及部分小样本人体研究，厚朴酚/和厚朴酚在多数市场作为膳食补充剂/化妆品原料/科研对照品管理；上禾生物（staherb）提供的是植物提取物/单体原料而非成品药品，终端产品须符合目标市场监管与标签法规，GABAₐ调节、抗焦虑、抗菌等为临床前趋势，不作为直接临床疗效宣称。

The above actions are mainly based on in vitro, animal, and limited human studies. Magnolol/Honokiol are mostly regulated as dietary supplement/cosmetic raw materials/reference standards. STAHBIO supplies plant extract/monomer raw materials, not finished drugs; finished products must comply with regional regulations and shall not use preclinical trends as clinical efficacy claims.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）