文章标题：Favorable neuroprotective effect of intra-arterial application of edaravone dexborneol in ischemic stroke rats
作者列表：Yalin Xi, Jingxia Ma, Shujun Lu
影响因子：2.5
期刊：Journal of Stroke & Cerebrovascular Diseases
发表时间：2023-9-22
DOI:10.1016/j.jstrokecerebrovasdis.2023.107356
文献主题：Abstract
Objective
The aim of this study was to investigate the neuroprotective effects of intra-arterial administration of edaravone dexborneol in rats with acute ischemic stroke and determine the optimal dose.
Materials and methods
Firstly, 120 male Sprague-Dawley rats (265–300 g) were selected to establish ischemic stroke models and were randomly divided into groups of sham-operation (Sham group), cerebral ischemia-reperfusion (IS group), permanent focal ischemia (PI group) and treatment (2MG group: 2 mg/kg, 4MG group: 4 mg/kg, 6MG group: 6 mg/kg) groups. There are 20 rats in each group, and ten rats in each group were randomly selected for Longa score and 2,3,5-triphenyl tetrazolium chloride staining to observe the changes in neurological function and the proportion of cerebral infarct volume in each group. Secondly, the remaining ten rats in each group were scored for Longa and tested for free radicals (hydroxyl radical; peroxynitrite; nitric oxide) and pro-inflammatory cytokines (interleukin 6; interleukin-1β; tumor necrosis factor-α). We monitored changes in the indicators in each group of rats.
