长沙上禾生物 喜树碱 Camptothecin中英文简介

长沙上禾生物科技有限公司

Changsha Sunho Biotech Co., Ltd

公司简介 | Company Profile

长沙上禾生物科技有限公司是一家专注于高活性天然抗肿瘤化合物研发、生产与销售的国家高新技术企业。公司以现代植物化学、肿瘤药理学与药物化学为核心，构建了从珍稀植物资源高值化利用、高纯度单体规模化分离到结构衍生与活性系统评价的全产业链技术平台。我们致力于为全球抗肿瘤新药研发、高端医药中间体及前沿生命科学研究领域提供高纯度、高质量、标准化的天然化合物及其关键衍生物原料，尤其在“喜树碱”等具有明确拓扑异构酶I抑制活性的著名天然抗肿瘤先导化合物的开发与供应领域，构筑了坚实的技术基础。

Changsha Sunho Bio-Tech Co., Ltd. is a national high-tech enterprise specializing in the R&D, production, and sales of highly active natural anti-tumor compounds. With modern phytochemistry, tumor pharmacology, and medicinal chemistry as its core, the company has built a full industrial chain technology platform spanning from the high-value utilization of rare plant resources, large-scale isolation of high-purity monomers, to structural derivatization and systematic activity evaluation. We are committed to providing high-purity, high-quality, standardized natural compounds and their key derivative raw materials for the global anti-tumor new drug R&D, high-end pharmaceutical intermediates, and cutting-edge life science research fields. We have established a solid technological foundation, particularly in the development and supply of renowned natural anti-tumor lead compounds with clear topoisomerase I inhibitory activity, such as "Camptothecin."

核心来源 | Core Source: 主要从珙桐科植物喜树（Camptotheca acuminataDecne.）的果实、根皮或枝叶中，通过先进的提取与色谱分离技术制备。亦可提供半合成或生物合成来源的高纯度产品。

Mainly prepared from the fruits, root bark, or leaves and branches of the Nyssaceae plant Camptotheca acuminata Decne. through advanced extraction and chromatographic separation techniques. High-purity products from semi-synthetic or biosynthetic sources are also available.

主打产品：喜树碱 | Core Product: Camptothecin

产品概述 | Product Overview

喜树碱 是一种从中国特有树种喜树中分离得到的喹啉类生物碱，是首个被发现并证实具有强效抗肿瘤活性的天然拓扑异构酶I抑制剂。其通过特异性抑制DNA拓扑异构酶I，干扰DNA复制与转录过程，导致DNA损伤和肿瘤细胞凋亡。由于其独特的五环结构和显著的体内外抗肿瘤活性，喜树碱被认为是20世纪最重要的天然抗肿瘤药物先导化合物之一。尽管其自身水溶性差、毒性大，但以其为母核结构优化开发出的伊立替康、拓扑替康、贝洛替康等衍生物已成为临床一线抗肿瘤药物。高纯度喜树碱及其关键中间体是现代抗肿瘤新药研发、结构修饰、作用机制研究和质量控制不可或缺的核心原料。

Camptothecin is a quinoline alkaloid isolated from the Chinese endemic tree Camptotheca acuminata, and is the first natural topoisomerase I inhibitor discovered and confirmed to possess potent anti-tumor activity. It works by specifically inhibiting DNA topoisomerase I, interfering with DNA replication and transcription processes, leading to DNA damage and tumor cell apoptosis. Due to its unique pentacyclic structure and significant in vitro and in vivo anti-tumor activity, camptothecin is considered one of the most important natural anti-tumor drug lead compounds of the 20th century. Although it has poor water solubility and high toxicity itself, derivatives such as irinotecan, topotecan, and belotecan, optimized based on its parent nucleus structure, have become first-line clinical anti-tumor drugs. High-purity camptothecin and its key intermediates are indispensable core raw materials for modern anti-tumor new drug R&D, structural modification, mechanism of action research, and quality control.

产品规格 | Product Specifications

主要应用领域 | Core Application Fields

1. 抗肿瘤新药研发与医药中间体 | Anti-tumor New Drug R&D and Pharmaceutical Intermediates

• 先导化合物与结构修饰：作为核心母核结构，用于设计、合成和筛选新型抗肿瘤化合物，特别是拓扑异构酶I抑制剂类药物。是伊立替康、拓扑替康等重磅药物合成的关键中间体。

• Lead Compound and Structural Modification: Serves as the core parent nucleus structure for designing, synthesizing, and screening novel anti-tumor compounds, especially topoisomerase I inhibitor drugs. It is a key intermediate for the synthesis of blockbuster drugs like irinotecan and topotecan.

• 新剂型开发：用于开发新型药物递送系统，如脂质体、纳米粒、前药等，以改善其水溶性、靶向性和降低毒性。

• New Formulation Development: Used in developing novel drug delivery systems, such as liposomes, nanoparticles, prodrugs, etc., to improve its water solubility, targeting, and reduce toxicity.

2. 生命科学与肿瘤机制研究 | Life Science and Tumor Mechanism Research

• 工具分子：作为特异性拓扑异构酶I抑制剂，用于研究DNA复制、转录、修复机制，以及细胞凋亡、细胞周期调控等基础生物学过程。

• Tool Molecule: As a specific topoisomerase I inhibitor, used to study fundamental biological processes such as DNA replication, transcription, repair mechanisms, as well as apoptosis and cell cycle regulation.

• 抗肿瘤活性筛选：作为阳性对照或标准品，用于体外抗肿瘤活性筛选模型的建立和验证。

• Anti-tumor Activity Screening: Serves as a positive control or reference standard for establishing and validating in vitro anti-tumor activity screening models.

3. 高端原料药与对照品 | High-end Active Pharmaceutical Ingredients and Reference Standards

• 原料药：用于制备相关喜树碱类抗肿瘤药物的原料药。

• Active Pharmaceutical Ingredient: Used as the raw material for preparing related camptothecin-class anti-tumor drugs.

• 分析对照品：作为HPLC/LC-MS等分析方法中定量测定喜树碱及其衍生物的化学对照品。

• Analytical Reference Standard: Serves as a chemical reference standard for the quantitative determination of camptothecin and its derivatives in analytical methods such as HPLC/LC-MS.

我们的核心优势 | Our Core Advantages

• “高纯度喜树碱单体”规模化分离纯化的技术专家：喜树碱在植物中含量低，且存在多种结构类似物，分离纯化极具挑战。我们拥有国际领先的制备色谱、结晶与手性分离纯化技术，能够稳定提供纯度高达90%-99% 的喜树碱单体，并严格控制10-羟基喜树碱等关键杂质的含量。我们实现了从克级到公斤级的标准化、规模化生产能力，能够满足从基础研究、新药筛选到关键中间体生产的全链条需求，建立了坚实的技术壁垒。

• “拓扑异构酶I抑制剂”核心机制的权威知识提供者：我们深度聚焦喜树碱作为首创、强效拓扑异构酶I抑制剂的科学价值。我们不仅提供原料，更能为客户提供其与拓扑异构酶I-DNA复合物稳定结合的详细分子机制、构效关系、以及由其衍生的临床药物（伊立替康等）的开发脉络等深度科学背景。我们将其定位为“抗肿瘤药物研发史上的里程碑式分子”，帮助客户在其研发和科研工作中建立深刻的科学认知和历史视角。

• “关键医药中间体”的可靠供应链保障者：我们深刻理解喜树碱及其衍生物在抗肿瘤药物产业链中的核心地位。我们不仅是化学品供应商，更是客户关键药物中间体供应链的稳定支柱。我们建立严格的质量管理体系和灵活的生产计划，保障产品的持续、稳定供应，支持客户（尤其是制药企业）的研发管线推进和商业化生产，降低供应链风险。

• “结构衍生与创新”的合作伙伴：基于对喜树碱化学结构的深刻理解和成熟的合成/分离平台，我们不仅能提供高纯度的喜树碱，还可根据客户需求，提供其关键衍生物中间体（如7-乙基-10-羟基喜树碱SN-38、10-羟基喜树碱等） 的定制合成与供应服务。我们具备与客户合作进行结构修饰、活性筛选等早期研发项目的能力，是客户在喜树碱类新药探索中的理想合作伙伴。

• “严格质控与国际标准”的践行者：我们按照原料药/高级医药中间体标准对喜树碱进行生产和质量控制，提供完整的结构确证、杂质谱研究、稳定性数据、详细的COA。我们的产品符合并可以定制满足CP、USP、EP、客户特定等各类药典及企业标准，满足全球药品注册申报对起始物料的严苛要求。

包装与储存 | Packaging & Storage

• 内包装：棕色玻璃瓶（推荐）或铝箔袋，充氮或抽真空，严格密封避光。

  Inner Packaging: Amber glass vial (recommended) or aluminum foil bag, nitrogen-filled or vacuum-sealed, tightly sealed and light-protected.

• 外包装：外用避光容器。高纯度产品建议冷链运输。

  Outer Packaging: External light-proof container. Cold chain transport is recommended for high-purity products.

• 储存条件：必须密封、避光、低温。长期储存建议-20°C冷冻，短期可在2-8°C冷藏。

  Storage Conditions: Must be kept sealed, protected from light, and at low temperature. Long-term storage at -20°C is recommended, short-term storage at 2-8°C refrigeration is acceptable.

联系我们 | Contact Us

长沙上禾生物科技有限公司

Charissa Liu

E-mail：sales05@staherb.cn    sales@staherb.cn

Whatsapp:+86-13657431735

Wechat:+86-13657431735

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