为华生物DSPE-PEG-NH2二硬脂酰基磷脂酰乙醇胺-聚乙二醇-氨基

DSPE-PEG-NH2 结构式

品牌：为华生物

产地：中国广州

CAS号：474922-26-4

PEG分子量：2k、3.4k、5k 其余的分子量可定制

外观：粘稠状或者固体粉末，取决于分子量。

常用溶剂：溶解于氯仿、二氯甲烷、热水中

DSPE-PEG-NH2是一种含有DSPE磷脂和胺的线性异双功能聚乙二醇化试剂，是反应性磷脂PEG试剂之一，它是一种有用的自组装试剂，用于制备接枝或聚乙二醇化脂质体或胶束，同时还提供用于生物结合的胺基。它通常用于脂质双分子层的靶向递送，以提高溶解度，PEG提供隐形性能，延长循环半衰期并减少非特异性蛋白质结合或细胞粘附，以及胺基用于生物结合靶向分子，包括抗体、适体、蛋白质和肽。PEG末端的氨基与叶酸反应，可用于制备DSPE-PEG-叶酸；与生物素琥珀酰亚胺酯反应，可用于制备DSPE-PEG-生物素；可与含羧酸基团的配体相连。

Dspe-peg-nh2 is a linear heterobifunctional PEGylation reagent containing DSPE phospholipid and amine. It is one of the reactive phospholipid peg reagents. It is a useful self-assembly reagent for preparing grafted or PEGylated liposomes or micelles, and also provides amine groups for biological binding. It is commonly used for targeted delivery of lipid bilayers to improve solubility, PEG provides stealth performance, prolongs circulating half-life and reduces non-specific protein binding or cell adhesion, and amine groups are used for biological binding of targeted molecules, including antibodies, aptamers, proteins and peptides. The amino group at the end of PEG reacts with folic acid, which can be used to prepare dspe-peg-folic acid; It can be used to prepare dspe-peg-biotin by reacting with biotin succinimide ester; Can be linked to a ligand containing a carboxylic acid group.

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