长沙上禾生物staherb龙胆苦甙Gentiopicroside产品概述中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

## 中文产品概述｜Product Overview (CN)

龙胆苦甙 / Gentiopicroside（别名龙胆苦苷、Gentiopicrin、5-乙烯基-6-(β-D-吡喃葡萄糖氧基)-5,6-二氢-1H,3H-吡喃并[3,4-c]吡喃-1-酮）

植物来源：龙胆科 Gentianaceae 龙胆 *Gentiana scabra* Bge.、条叶龙胆 *G. manshurica* Kitag.、三花龙胆 *G. triflora* Pall.、坚龙胆 *G. rigescens* Franch.、秦艽 *G. macrophylla* Pall. 的干燥根及根茎（非獐牙菜属 *Swertia* 全草——后者主含獐芽菜苦苷 Swertiamarin，不可混标）；龙胆苦甙是龙胆"极苦"的直接物质源与《中国药典》龙胆含量测定唯一指标（龙胆根≥3.0% DW、坚龙胆≥1.5% DW），占根中裂环烯醚萜苷 80%–90%。

供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®，2010 年长沙麓谷，环创 B8 202，国家高新技术企业，龙胆苦甙为肝胆/消化线医药级单体主力）

化学灵魂：龙胆苦甙是龙胆属药材第一指标成分与"苦寒清热、泻肝胆火"的现代物质基础——单一裂环烯醚萜苷（secoiridoid glycoside）：环戊烷骈吡喃酮母核 + C-6 β-D-葡萄糖苷 + C-5 乙烯基；系统名 (5R-trans)-6-(β-D-glucopyranosyloxy)-5,6-dihydro-5-ethenyl-1H,3H-pyrano[3,4-c]pyran-1-one；分子式 C₁₆H₂₀O₉，MW 356.32，CAS 20831-76-9，EINECS 244-070-2；白色至浅黄针状结晶性粉末，味极苦（水阈值≈1:20000），易溶于水/甲醇/乙醇、难溶石油醚/氯仿，mp 191–193℃，[α]ᴅ²⁰ -196°～-210°（水），UV λmax 270 nm（MeOH，ChP 流动相甲醇-水 30:70 定量），吸湿、光热易褐变。

Staherb 产品定位：双轨柔性——"龙胆标化提取物（肝胆保健/天然苦味剂）× 高纯龙胆苦甙单体（医药中间体/对照品/科研）"。医药线守《中国药典》龙胆/秦艽基源与含量下限，保健线作"苦味健胃+保肝利胆"背景配料；Staherb 官网明列"龙胆苦甙 5%/10%/20%/40% HPLC 提取物、90%/95%/≥98% HPLC 单体白晶、科研级 10 mg–1 g、浅黄–棕黄提取物粉、1/5/25 kg 充氮铝箔、2–8℃ 密封避光"。

规格矩阵：

• 龙胆提取物：龙胆苦甙 5% / 10% / 20% / 40% HPLC（浅黄–棕黄粉，肝胆保健/苦味剂/开胃酒）

• 高纯单体轨：90% / 95% / ≥98% HPLC（白晶），科研级 10 mg–1 g 分装

- 伴生标记：COA 同条件分 Swertiamarin（若投獐牙菜属才升，龙胆根仅痕–次）、Sweroside、Amarogentin（痕量）——Staherb 明拒"龙胆根提物混标獐芽菜苦苷当龙胆苦甙%"。

厂区定位：长沙高新麓谷 B8 为龙胆/秦艽干根（东北关龙胆/西北甘陕秦艽基地秋采、≤60℃ 通风干至水分≤10%）→ 除杂 10–20 目→ 60%–80% EtOH 回流/冷浸（≤60℃ 护苷键）→ 板框/离心→ 大孔 AB-8/D101/HPD-100 水洗切糖色素、30%–50% EtOH 短洗、60%–75% EtOH 洗脱苦甙段→ 制备 HPLC C18 水-乙腈-0.1% 甲酸或 ODS 柱抛单体→ 水/乙醇 0–4℃ 重结晶→ 龙胆苦甙≥95%/98% 白晶→ 喷雾/冻干标化粉或低温真空干单体→ 充氮铝箔 2–8℃（单体 -20℃）分装与出口质控中心；干根来自东北/西北/西南定点茶园，长沙麓谷 B8 非种植产地（COA 注 "Origin: China / Processed in Changsha, Hunan"）。

概述正文

龙胆苦甙是把"龙胆科根里的裂环烯醚萜苷"保苷键提纯与充氮稳化的典型——Staherb 不卖模糊龙胆粗粉，而是把关龙胆/秦艽干根经低温醇提（避>60℃ 防苷键水解）、大孔树脂把多糖/色素/生物碱切掉、60%–75% 乙醇把龙胆苦甙洗下、制备 HPLC/重结晶抛到 98% 白晶、全程≤60℃ 提/≤50℃ 减浓/≤40℃ 干/避光充氮防吸湿褐变，按终端反向派单：① 肝胆保健（核心主场）——龙胆苦甙 90%–98% 单体或 20%–40% 标化粉入胶囊片，传统"保肝利胆、清肝胆湿热"背景，配水飞蓟素/姜黄/朝鲜蓟，ALT/AST 背景、胆汁流量背景（细胞动物/观察性，不治病）；② 苦味健胃与功能食品——利用极苦阈值作天然苦味剂入开胃酒/消化利口酒/苦味 tonic/功能茶饮，激活口腔 TAS2R 反射促唾液胃液分泌（传统"苦味健胃"已确证）；③ 抗炎辅助——配白芍/黄芩入关节/肠易激背景组合，NF-κB/TNF-α/IL-6 背景；④ 化妆品舒缓——0.5%–2% 入抗红舒缓精华，抗炎 ROS 背景；⑤ 兽药——畜禽鱼保肝利胆剂；⑥ 科研对照——≥98% 作 HPLC 270 nm / LC-MS 外标、NF-κB/Nrf2 阳性对照，附 HPLC-DAD+MS+NMR。在长沙高新麓谷 B8 报"Gentiopicroside HPLC 270 nm（ChP 甲醇-水 30:70 或 C18 乙腈-0.1% 醋酸 9:91，EGCG 对照品外标）+ 同条件 Swertiamarin/Sweroside/Amarogentin 分峰 + 水分≤5%(单体) + 重金属(Pb≤0.5/Cd≤0.3/As≤1 ppm 药用/食品限) + 农残(GB2763+EU396) + 溶剂残留（EtOH 痕）+ 微生物 + 40℃/75%RH 6 月加速"。产品定位于龙胆科龙胆/秦艽干燥根及根茎中单一裂环烯醚萜苷（C16H20O9、mp 191℃、[α]ᴅ -196°、UV 270 nm、占根苦甙 80%–90%、ChP 龙胆≥3.0% DW）的天然苦味保肝利胆配料；原料页仅作"secoiridoid glycoside from Gentiana spp. root, bitter principle & ChP marker, hepatobiliary/stomachic/anti-inflam traditional background"；不跨境宣称治疗肝炎/胆囊炎/类风湿/阿尔茨海默（属药品范畴），保肝利胆/抗炎/苦味健胃为传统功效+细胞动物研究背景；水溶性好但吸湿光敏，2–8℃ 密封避光、单体 -20℃ 充氮，脾胃虚寒者慎用提示。

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## English Product Overview｜EN

Gentiopicroside (syn. gentiopicrin, (5R-trans)-6-(β-D-glucopyranosyloxy)-5,6-dihydro-5-ethenyl-1H,3H-pyrano[3,4-c]pyran-1-one)

Botanical source: Dried root & rhizome of Gentianaceae Gentiana scabra Bge., G. manshurica Kitag., G. triflora Pall., G. rigescens Franch., G. macrophylla Pall. (NOT *Swertia* spp. whole-herb — yields swertiamarin, not merged); gentiopicroside is the direct bitter principle of gentian and sole ChP quantitative marker (gentian root ≥3.0% DW, rigid gentian ≥1.5% DW), 80–90% of root secoiridoid glycosides.

Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®, founded 2010 Changsha Lugu B8-202, national hi-tech, gentiopicroside as hepatobiliary/digestive pharma-grade monomer line)

Chemical soul: Gentiopicroside is the first marker and modern substance-base of "bitter-cold clear liver-gallbladder fire" in *Gentiana* — one secoiridoid glycoside: cyclopentane-fused pyranone + C-6 β-D-glucoside + C-5 ethenyl; formula C₁₆H₂₀O₉, MW 356.32, CAS 20831-76-9, EINECS 244-070-2; white-to-pale-yellow needle crystal powder, extremely bitter (water threshold ~1:20000), freely water/MeOH/EtOH, poorly pet-ether/CHCl₃, mp 191–193℃, [α]ᴅ²⁰ -196° to -210° (H₂O), UV λmax 270 nm (MeOH, ChP mobile MeCN-water 30:70), hygroscopic, light/heat browns.

Staherb positioning: dual-track flexible — "gentian standardized extract (hepatobiliary/natural bittering) × high-pure gentiopicroside monomer (API-intermediate/reference/R&D)". Pharma line obeys ChP *Gentiana* base & content floor, nutra line as "bitter stomachic + hepatobiliary" background; Staherb site: "gentiopicroside 5/10/20/40% HPLC extract, 90/95/≥98% HPLC white crystal, research 10mg–1g, pale-yellow–tan extract powder, 1/5/25kg N₂-foil, 2–8℃ sealed dark".

Spec matrix:

• Gentian extract: Gentiopicroside 5% / 10% / 20% / 40% HPLC (pale-yellow–tan powder)

- High-pure monomer: 90% / 95% / ≥98% HPLC (white crystal), research 10 mg–1 g

• Companions: COA same-cond splits swertiamarin (trace-minor, rises only if Swertia mixed), sweroside, amarogentin (trace) — Staherb rejects "gentian-root extract merging swertiamarin as gentiopicroside%".

Site role: Changsha Lugu B8 = gentian/Qin-jiao dry root (NE Guan-gentian/NW Gansu-Shaanxi Qin-jiao base autumn-harvest, ≤60℃ vent-dry moisture≤10%) → de-stem 10–20 mesh → 60–80%EtOH reflux/cold-soak (≤60℃ protect glycosidic bond) → plate/centrifuge → macroporous AB-8/D101/HPD-100 water-wash cut polysac/pigment/alkaloid, 30–50%EtOH short, 60–75%EtOH elute bitter-glycoside-cut → prep-HPLC C18 H₂O-MeCN-0.1%FA or ODS polish monomer → water/EtOH 0–4℃ recryst → gentiopicroside≥95/98% white crystal → spray/FD std powder or ≤40℃ vac-dry monomer → N₂-foil 2–8℃ (monomer -20℃) repack & export QC center; dry root from NE/NW/SW registered bases, Changsha Lugu B8 not plantation (COA "Origin: China / Processed in Changsha, Hunan").

Overview body

Gentiopicroside is the typical case of industrializing "secoiridoid glycoside from gentian root" with glycosidic-bond protection and N₂ stabilization — Staherb doesn't sell vague gentian crude, but low-temp EtOH extract (avoid >60℃ glycoside hydrolyze), macroporous cuts polysac/pigment/alkaloid, 60–75% EtOH elutes gentiopicroside, prep-HPLC/recryst polishes 98% white crystal, whole line ≤60℃ extract / ≤50℃ conc / ≤40℃ dry / dark N₂ anti-hygroscopic-brown, reverse-dispatch: ① hepatobiliary nutraceutical (core home) — 90–98% monomer or 20–40% std in cap/tab, traditional "protect liver / increase bile flow / clear liver-fire" background, blend silymarin/curcumin/artichoke, ALT/AST & bile-flow background (cell-animal/observational, not disease claim); ② bitter stomachic & functional food — use extreme bitter threshold as natural bittering agent in apéritif/digestif/bitter tonic/functional tea, oral TAS2R reflex saliva/gastric-secret↑ (traditional "bitter stomachic" established); ③ anti-inflam adjunct — with paeony/scutellaria for joint/IBS background, NF-κB/TNF-α/IL-6 background; ④ cosmetic soothing — 0.5–2% in anti-red serum, anti-inflam ROS background; ⑤ vet — livestock/fish hepatobiliary protectant; ⑥ R&D reference — ≥98% as HPLC 270nm / LC-MS external, NF-κB/Nrf2 positive-control, HPLC-DAD+MS+NMR attached. At Changsha Lugu B8 report "Gentiopicroside HPLC 270nm (ChP MeOH-H₂O 30:70 or C18 MeCN-0.1%AcOH 9:91, gentiopicroside CRS ext) + same-cond swertiamarin/sweroside/amarogentin split + moisture≤5%(monomer) + heavy(drug/food Pb≤0.5/Cd≤0.3/As≤1 ppm) + pesticide(GB2763+EU396) + solvent(EtOH trace) + microbe + 40℃/75%RH 6mo accel". Positioned as single secoiridoid glycoside from Gentiana spp. dried root (C16H20O9, mp 191℃, [α]ᴅ -196°, UV 270nm, 80–90% of root bitter-glycosides, ChP gentian≥3.0% DW) natural bitter hepatobiliary-stomachic ingredient; label only "secoiridoid glycoside from Gentiana root, bitter principle & ChP marker, hepatobiliary/stomachic/anti-inflam traditional background"; no cross-border treat-hepatitis/cholecystitis/RA/Alzheimer claim (drug scope), hepatobiliary/anti-inflam/bitter-stomachic traditional+fundamental-cell-animal background only; water-soluble but hygroscopic light-sensitive, 2–8℃ sealed dark, monomer -20℃ N₂, caution in spleen-stomach deficiency-cold.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）