长沙上禾生物staherb龙胆苦甙Gentiopicroside原料产地中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

中文原料产地｜Raw Material Origin (CN)

产品：龙胆苦甙 / Gentiopicroside（C₁₆H₂₀O₉，CAS 20831-76-9，龙胆科龙胆属 Gentiana scabra/manshurica/triflora/rigescens 及秦艽 G. macrophylla 干燥根及根茎裂环烯醚萜苷）

供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®，2010 年长沙麓谷，环创 B8 202，国家高新技术企业）

植物基源与种源：龙胆苦甙只从龙胆科龙胆属根及根茎提，不从獐牙菜属全草提（后者主含獐芽菜苦苷 Swertiamarin，Staherb 单列另一产品线，不可混标）。《中国药典》法定四基源——龙胆 Gentiana scabra Bge.（主）、条叶龙胆 G. manshurica Kitag.（关龙胆商品主流）、三花龙胆 G. triflora Pall.（东北零星）、坚龙胆 G. rigescens Franch.（西南）；保肝利胆经典配伍另收秦艽 G. macrophyla Pall.。同株伴生 Swertiamarin/Sweroside/Amarogentin（痕–次量），龙胆苦甙占根中裂环烯醚萜苷 80%–90%，是 ChP 唯一定量标记（龙胆≥3.0%、坚龙胆≥1.5% DW，实测龙胆 4.02%–6.34%、条叶龙胆 4.15%、三花龙胆 3.66%、坚龙胆 5.01%  ）。

Staherb 产地策略（"东北关龙胆主轴 + 西北秦艽辅供 + 西南坚龙胆调剂 + 华东条叶龙胆滚动补入"多源定点）

Staherb 采用"公司+道地基地+备案"订单农业：在龙胆科道地产区建定点备案/部分 GAP 指导基地收秋采干根→除杂→≤60℃ 通风干至水分≤10%→密封运长沙，麓谷 B8 仅做低温醇提→大孔树脂→制备 HPLC/重结晶→标化分装，非种植产地（COA 注 "Origin: China / Processed in Changsha, Hunan"）。多源策略规避单产区气候波动，保工业批龙胆苦甙基线稳（投料优选干根龙胆苦甙≥3.0%–4.0% DW，关龙胆批常 4%–6%）。

核心产区与投料特点

• 主供主轴｜东北·关龙胆（黑龙江牡丹江/吉林抚松延边/辽宁本溪/内蒙古呼伦贝尔）：传统"关龙胆"产区，原植物以条叶龙胆为主、龙胆次之、三花龙胆零星，高山腐殖土、生长 3–5 年秋采；干根龙胆苦甙 4.0%–6.3% DW（条叶龙胆 4.15%、龙胆 4.02%–6.34%、三花 3.66%），是 Staherb ≥98% 单体得率最高的主力前体，5%–40% 标化粉与 90%/95%/98% 单体主线均以此为主。

• 重要辅供｜西北·秦艽（甘肃定西/临夏、陕西宝鸡/凤县、青海黄南、山西忻州、四川阿坝）：高海拔 2000–3000 m 秦艽 G. macrophyla，苦味浓郁、环烯醚萜+生物碱（龙胆碱）并存；作保肝利胆/祛风湿复方高标批基源调剂，入厂严控根腐与硫熏。

• 西南调剂｜云南·坚龙胆（云南大理/楚雄/文山、贵州黔西南）：G. rigescens 主产，ChP 下限 1.5% 但优质批可达 5.01% DW；仅用于成本调剂与"滇龙胆"定制批，涩感略异、伴生微量当药苷略高。

• 滚动补入｜华东·条叶龙胆（浙江临安/安徽宣城/江苏南部）：严龙胆/苏龙胆传统源，条叶龙胆为主；按年份含量波动补入东南向客户定制批。

• 拒收红线：獐牙菜属（Swertia 全草，Swertiamarin 异常升高）、非龙胆科混杂（当药/黄龙胆草形态 TLC 鉴）、春采一年生根（苦甙未积累）、陈根（存>3 年光氧化苷键水解苦甙↓）、硫熏（SO₂>150 mg/kg）、霉变、农残超（GB 2763 龙胆吸药作物严检六六六/DDT/咪鲜胺/菊酯）、Pb>0.5 ppm（药用）/Cd>0.3 ppm、干根龙胆苦甙<2.0% DW。

采收与初制窗口

• 春秋二季采挖（秋采为主，9–10 月苷峰）→ 洗净→ 除去茎叶须根→ ≤60℃ 通风干燥或阴干至水分≤10%（忌暴晒>70℃ 致苷键水解、忌硫熏）→ 扎把/切片；每批附基原（G. scabra/manshurica/triflora/rigescens/macrophyla）+ 产区（到县）+ 采期（到年）+ 干法 + 初水分 + 初龙胆苦甙（HPLC 270 nm）+ 初伴生 Swertiamarin% + 农残批号 + 基地备案号**。

• Staherb 入厂拒收：陈货（存>3 年）、硫熏、獐牙菜属未声明混入、干根苦甙<2.0% DW、TLC 基原不符。

入厂基线（Staherb 快检红线）

• 干根：水分≤10%、总灰分≤6%、酸不溶灰≤1.5%、SO₂≤150 mg/kg；

• 龙胆苦甙（HPLC 270 nm，ChP 甲醇-水 30:70 或 25:75，龙胆苦甙 CRS 外标）≥3.0% DW（关龙胆优选≥4.0%，拒<2.0%）；

• 伴生 Swertiamarin 痕–次量（若>1.0% DW 预警獐牙菜混入）、Sweroside/Amarogentin 痕量；

• 重金属：Pb≤0.5 ppm（药用严限）/Cd≤0.3 ppm/As≤1 ppm/Cu≤10 ppm；

• 农残：GB 2763 + 欧盟 396/2005 + 日本肯定列表（龙胆严检有机氯/有机磷/咪鲜胺/菊酯）；

• 感官：根条顺直、黄棕至棕褐、断面黄白、味极苦、无红心烂头。

溯源双向链

干根批：附省/县（黑龙江牡丹江/吉林抚松/辽宁本溪/内蒙呼伦贝尔、甘肃定西/陕西宝鸡/青海黄南、云南大理/楚雄、浙江临安/安徽宣城）/基原（到种）/采期（2025-10 秋采）/干法/初水分/初龙胆苦甙%/初 Swertiamarin%/农残批号/基地备案号；Staherb 单体批号 ↔ 干根批号 ↔ 初制厂备案号三级双向，COA 可追到"黑龙江牡丹江 2025-10 秋采条叶龙胆、初龙胆苦甙 5.2% DW → 60% EtOH≤60℃ 提 → AB-8 60–75% EtOH 洗脱 → 制备 HPLC C18 → 0–4℃ 重结晶 → 龙胆苦甙 98.3% HPLC + Swertiamarin 0.3% + mp 191℃ + [α]ᴅ -198°"。

⚠️ Staherb 合规边界：原料页表述"dried root & rhizome of Gentianaceae Gentiana scabra/manshurica/triflora/rigescens (ChP gentian) ± G. macrophyla (Qin-jiao), NOT Swertia spp. (swertiamarin line); multi-source registered NE Guan-gentian≥primary + NW Qin-jiao + SW rigid-gentian + E-China strip-gentian roll-adjust; Changsha Lugu B8 = low-temp EtOH extract + macroporous + prep-HPLC recryst standardize-repack center NOT plantation"；所有出口批附 "Gentiopicroside HPLC 270nm (ChP methanol-water 30:70, CRS ext), ChP gentian≥3.0%/rigid≥1.5% DW, not from Swertia, hygroscopic light-sensitive 2-8℃ dark monomer -20℃ N₂"；不跨境宣称治疗肝炎/胆囊炎/类风湿/阿尔茨海默。

English Raw Material Origin｜EN

Product: Gentiopicroside (syn. gentiopicrin, secoiridoid glycoside from Gentianaceae Gentiana scabra/manshurica/triflora/rigescens & G. macrophyla dried root & rhizome, CAS 20831-76-9, C₁₆H₂₀O₉)

Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®, Changsha Lugu B8-202, since 2010)

Botanical source & germplasm: Gentiopicroside only from Gentiana root-rhizome, never from Swertia whole-herb (latter yields swertiamarin, Staherb separate product line, not merged). ChP statutory four bases — Gentiana scabra Bge. (primary), G. manshurica Kitag. (Guan-gentian trade main), G. triflora Pall. (NE sporadic), G. rigescens Franch. (SW rigid-gentian); hepatobiliary classic formula also takes Qin-jiao G. macrophyla Pall.. Companions swertiamarin/sweroside/amarogentin (trace-minor), gentiopicroside 80–90% of root secoiridoids, sole ChP quantitative marker (gentian≥3.0%, rigid≥1.5% DW; measured gentian 4.02–6.34%, strip-gentian 4.15%, three-flower 3.66%, rigid 5.01% DW  ).

Staherb origin strategy ("NE Guan-gentian primary + NW Qin-jiao co-feed + SW rigid-gentian adjust + E-China strip-gentian roll-adjust" multi-source registered)

Staherb runs "company+dao-di base+registry" order-farming: fixed registered / partial GAP-guided bases in gentian dao-di belts → autumn harvest dry root → de-stem → ≤60℃ vent-dry moisture≤10% → sealed to Changsha, Lugu B8 only does low-temp EtOH extract → macroporous → prep-HPLC/recryst → standardize-repack, NOT plantation (COA "Origin: China / Processed in Changsha, Hunan"). Multi-source avoids single-region climate swing, keeps industrial gentiopicroside baseline steady (feed pref dry-root ≥3.0–4.0% DW, Guan batch often 4–6%).

Core regions & feed traits

• Primary spine｜NE Guan-gentian (Heilongjiang Mudanjiang, Jilin Fusong-Yanbian, Liaoning Benxi, Inner-Mongolia Hulunbuir): traditional "Guan-gentian", botanical mainly G. manshurica with G. scabra secondary, G. triflora sparse, alpine humus, 3–5 yr growth autumn-cut; dry-root gentiopicroside 4.0–6.3% DW (strip 4.15%, scabra 4.02–6.34%, triflora 3.66%), Staherb ≥98% monomer highest-yield primary precursor, 5–40% std + 90/95/98% monomer main line.

• Important co-feed｜NW Qin-jiao (Gansu Dingxi-Linxia, Shaanxi Baoji-Fengxian, Qinghai Huangnan, Shanxi Xinzhou, Sichuan Aba): 2000–3000m G. macrophyla, bitter strong, iridoid+alkaloid (gentianine) coexist; hepatobiliary/anti-rheumatic combo high-std batch adjust, inbound strict root-rot & SO₂-bleach.

• SW adjust｜Yunnan rigid-gentian (Yunnan Dali-Chuxiong-Wenshan, Guizhou Qianxinan): G. rigescens, ChP floor 1.5% but good batch 5.01% DW; cost-adjust & "Dian-longdan" custom only, astringency slightly off, companion sweroside marginally higher.

• Roll-adjust｜E-China strip-gentian (Zhejiang Lin'an, Anhui Xuancheng, S Jiangsu): Yan-gentian/Su-gentian traditional source, G. manshurica main; year-fluctuation fill-in for SE-Asia custom.

• Reject gates: Swertia spp. whole-herb (swertiamarin anomaly high), non-Gentianaceae admix (morph+TLC), spring 1-yr root (glycoside not accumulated), aged>3yr photo-hydrolyze, SO₂-bleach(>150mg/kg), mold, pesticide over (GB2763 gentian tight BHC/DDT/prochloraz/pyrethroid), Pb>0.5ppm(drug)/Cd>0.3ppm, dry-root gentiopicroside<2.0% DW.

Harvest & primary-process

• Spring/autumn dig (autumn Sep–Oct glycoside peak) → wash → remove stem/fiber → ≤60℃ vent-dry or shade-dry moisture≤10% (no >70℃ sun-bake hydrolyze glycosidic bond, no SO₂) → bundle/slice; each lot with basorigin (to species) + county-origin + harvest(year) + dry-mode + initial moisture + initial gentiopicroside (HPLC 270nm) + initial swertiamarin% + pesticide lot + base-reg.

• Staherb rejects aged>3yr, SO₂-bleached, Swertia undeclared admix, dry-root <2.0% DW, TLC base mismatch.

Inbound baseline (Staherb quick-test redline)

• Dry root: moisture≤10%, total-ash≤6%, acid-insol-ash≤1.5%, SO₂≤150 mg/kg;

• Gentiopicroside (HPLC 270nm, ChP MeOH-H₂O 30:70 or 25:75, gentiopicroside CRS ext) ≥3.0% DW (Guan pref≥4.0%, reject<2.0%);

• Companion swertiamarin trace-minor (if>1.0% DW warn Swertia mix), sweroside/amarogentin trace;

• Heavy: Pb≤0.5ppm (drug strict)/Cd≤0.3/As≤1/Cu≤10;

• Pesticide: GB 2763 + EU 396/2005 + JP pos-list (gentian tight organochlorine/organophosphorus/prochloraz/pyrethroid);

• Sensory: straight root, yellow-brown to brown, section yellow-white, extremely bitter, no red-heart rot.

Genealogy bidirectional chain

Dry-root lot: with province/county (Heilongjiang Mudanjiang/Jilin Fusong/Liaoning Benxi/Inner-Mongolia Hulunbuir, Gansu Dingxi/Shaanxi Baoji/Qinghai Huangnan, Yunnan Dali/Chuxiong/Zhejiang Lin'an/Anhui Xuancheng) / basorigin (to species) / harvest (2025-10 autumn) / dry-mode / initial moisture / initial gentiopicroside% / initial swertiamarin% / pesticide lot / base-reg; Staherb monomer lot ↔ dry-root lot ↔ primary-plant reg 3-tier bidirectional, COA traceable to "Heilongjiang Mudanjiang 2025-10 autumn G. manshurica, initial gentiopicroside 5.2% DW → 60%EtOH≤60℃ → AB-8 60–75%EtOH elute → prep-HPLC C18 → 0–4℃ recryst → gentiopicroside 98.3% HPLC + swertiamarin 0.3% + mp 191℃ + [α]ᴅ -198°".

Supplier note: Staherb labels "dried root & rhizome of Gentianaceae Gentiana scabra/manshurica/triflora/rigescens (ChP gentian) ± G. macrophyla (Qin-jiao), NOT Swertia spp. (swertiamarin line); multi-source registered NE Guan-gentian≥primary + NW Qin-jiao + SW rigid-gentian + E-China strip-gentian roll-adjust; Changsha Lugu B8 = low-temp EtOH extract + macroporous + prep-HPLC recryst standardize-repack center NOT plantation"; every export lot carries "Gentiopicroside HPLC 270nm (ChP MeOH-H₂O 30:70, CRS ext), ChP gentian≥3.0%/rigid≥1.5% DW, not from Swertia, hygroscopic light-sensitive 2-8℃ dark monomer -20℃ N₂"; no cross-border treat-hepatitis/cholecystitis/RA/Alzheimer claim.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）