10YR企业会员
发布人：长沙上禾生物科技有限公司
发布日期:2026/8/15 13:20:21
公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证
☎：19573130018 杨经理（微信同号）
产品：小白菊内酯 / Parthenolide（别名欧苷菊内酯、银胶菊内酯、Chrysanthemum parthenium 活性原则）
植物来源：菊科 Asteraceae 小白菊 Tanacetum parthenium (L.) Sch.Bip.（异名 Chrysanthemum parthenium） 的干燥叶、花蕾及地上部分（非根、非种子；花前采收叶中含量最高，标提以叶:花蕾 3:1 混合投料）；小白菊内酯是小白菊"预防偏头痛/抗炎"的传统物质基础与唯一标志倍半萜内酯，占植株倍半萜内酯总量 70%–90%，干叶 0.2%–0.8%、高选育种可达 1%–2%。
供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®，2010 年长沙麓谷，环创 B8 202，国家高新技术企业，小白菊内酯为抗炎/肿瘤工具分子与医药中间体主力）
唯一核心活性成分：小白菊内酯是小白菊属药材的第一标志成分与全部"抗炎、抗偏头痛、免疫调节"的现代物质基础——不是多成分家族主角（同株伴行樟黄苷/圣菊苷等黄酮、桉叶素/樟脑型单萜挥发油、绿原酸类均为背景），而是单一愈创木烷型倍半萜内酯（sesquiterpene γ-lactone）：系统名 (1aR,7aS,10aS,10bS,E)-1a,5-二甲基-8-亚甲基-2,3,6,7,7a,8,10a,10b-八氢氧杂环丙并[2',3':9,10]环癸[1,2-b]呋喃-9(1aH)-酮，俗称 4,5α-环氧-6β-羟基-愈创木烷-1(10),11(13)-二烯-12-酸 γ-内酯；分子式 C₁₅H₂₀O₃，MW 248.32，CAS 20554-84-1，EINECS 692-532-0。白色至类白色针状/结晶性粉末，易溶 DMSO（≥100 mg/mL）/乙醇（≥20 mg/mL）/丙酮/氯仿、微溶于水（LogP≈2.42，水溶是制剂第一难点），mp 115–116℃，[α]ᴅ²⁰ -81.4°（c=1.04, CHCl₃），UV λmax ~205–220 nm（HPLC-UV 220 nm 定量），热/光/碱/环氧开环敏、对空气湿氧渐褐。
药效团化学本质：两个亲电中心——① α-亚甲基-γ-内酯环（α-methylene-γ-lactone，C-8 亚甲基共轭内酯）② 4,5-环氧基（epoxide）；二者均可对蛋白质半胱氨酸巯基（-SH）行 Michael 加成/烷基化共价修饰，是它不可逆抑 IKKβ(Cys179)/p65(Cys38)/HDAC1/GSK3β/Nrf2 KEAP1 的化学根基——"活性靠亲电、稳定靠避氧碱"是产业核心矛盾。
Staherb 规格—活性对应：
小白菊标提（Feverfew P.E.）：Parthenolide 0.2%–0.8%（膳食级主轴）、1%–2%（医药中间体/研究级）HPLC-UV@220 nm，低温 60%–75% EtOH 55–65℃ 提、喷雾≤50℃
高纯单体轨：90% / 95% / 98% / 99% HPLC-UV@220 nm（白晶），科研级 10 mg–1 g 分装
伴生背景：黄酮（樟黄苷/圣菊苷）、单萜挥发油（桉叶素/樟脑）、绿原酸——不单独标化、不作功效主轴
⚠️ Staherb 合规边界：原料页统一表述"Parthenolide (CAS 20554-84-1, C₁₅H₂₀O₃) as sesquiterpene lactone & sole marker-active of Asteraceae Tanacetum parthenium aerial parts, α-methylene-γ-lactone + 4,5-epoxide electrophilic warhead, NF-κB/IKKβ/p65/HDAC1 covalent modifier"；不跨境宣称治疗偏头痛/类风湿/白血病/乳腺癌（属药品范畴），抗偏头痛为 ESCOP/EMA"传统用于预防"背景、抗炎/抗肿瘤为细胞动物与临床前背景；微水溶、热光碱敏、环氧亲电有 H317 致敏风险，单体 -20℃ 避光充氮 DMSO 母液、标提 2–8℃ 充氮防潮，抗凝/华法林/术前/妊娠哺乳/菊科过敏红线 COA 必注。
Product: Parthenolide (syn. feverfew lactone, (1aR,7aS,10aS,10bS,E)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-9(1aH)-one)
Botanical source: Dried leaves, flower buds & aerial parts of Asteraceae Tanacetum parthenium (L.) Sch.Bip. (syn. Chrysanthemum parthenium) (not root/seed; pre-flower leaf highest, feed leaf:bud 3:1); parthenolide is the sole marker-active sesquiterpene lactone and modern substance-base of feverfew "migraine-prevention/anti-inflam", 70–90% of plant sesquiterpene lactones, dry leaf 0.2–0.8%, selected cultivars 1–2%.
Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®, Changsha Lugu B8-202, since 2010)
Sole core active: Parthenolide is the first marker and entire modern basis of "anti-inflam / migraine-prophylaxis / immune-mod" in T. parthenium — not a multi-molecule family hero (companions tanetin/santonin-like flavonoids, eucalyptol/camphor monoterpenes, chlorogenic acid are background), but one guaiane-type sesquiterpene γ-lactone: common name 4,5α-epoxy-6β-hydroxy-germacra-1(10),11(13)-dien-12-oic acid γ-lactone; formula C₁₅H₂₀O₃, MW 248.32, CAS 20554-84-1, EINECS 692-532-0. White-to-off-white needle/crystal powder, freely DMSO (≥100 mg/mL) / EtOH (≥20 mg/mL) / acetone / CHCl₃, poorly water (LogP≈2.42, aqueous solubility is formulation #1 hurdle), mp 115–116℃, [α]ᴅ²⁰ -81.4° (c=1.04, CHCl₃), UV λmax ~205–220 nm (HPLC-UV 220 nm quant), heat/light/base/epoxide-open sensitive, air-moist oxidizes brown.
Warhead chemistry: two electrophilic centers — ① α-methylene-γ-lactone ring (C-8 exocyclic methylene conjugated lactone) ② 4,5-epoxide; both do Michael addition / alkylation on protein cysteine -SH, the chemical root of irreversible IKKβ(Cys179)/p65(Cys38)/HDAC1/GSK3β/Nrf2-KEAP1 covalent modulation — "activity from electrophile, stability from O₂/base avoidance" is the industrial core contradiction.
Staherb spec↔active map:
Feverfew P.E.: Parthenolide 0.2–0.8% (dietary spine), 1–2% (API-intermediate/research) HPLC-UV@220nm, low-temp 60–75%EtOH 55–65℃, spray≤50℃
High-pure monomer: 90% / 95% / 98% / 99% HPLC-UV@220nm (white crystal), research 10 mg–1 g
Companions: flavonoids/monoterpenes/chlorogenics — not individually standardized.
Why it is the "key active" (mechanism anchor)
Parthenolide's activity roots in electrophilic warhead → covalent cysteine modification: (1) IKKβ Cys179 alkylate → IκBα not phosphorylate → NF-κB p65 cytosol-retain → TNF/IL-6/IL-1β/COX-2/iNOS↓ (anti-inflam & migraine platelet 5-HT/PG release↓); (2) HDAC1 selective inhibit (not class I/II bulk) → chromatin relax pro-apoptotic; (3) STAT3 dimerization block → anti-prolif; (4) Nrf2-KEAP1 modify → biphasic redox; (5) cancer-stem-cell (CD44+/CD24-) selective apoptose preclinical. Multi-target but covalent not receptor-agonic — clinically mapped to ESCOP/EMA "traditional feverfew for migraine prophylaxis" (not acute), cell-animal evidence for RA/IBD/cancer/neuro only.
Supplier note: Staherb labels "Parthenolide (CAS 20554-84-1, C₁₅H₂₀O₃) as sesquiterpene lactone & sole marker-active of Asteraceae Tanacetum parthenium aerial parts, α-methylene-γ-lactone + 4,5-epoxide electrophilic warhead, NF-κB/IKKβ/p65/HDAC1 covalent modifier"; no cross-border "treats migraine/RA/AML/breast-cancer" claim (drug scope), migraine-prophylaxis ESCOP/EMA traditional + anti-inflam/anticancer cell-animal/preclinical background only; poorly water, heat/light/base-sensitive, epoxide electrophile H317 sensitization risk, monomer -20℃ dark N₂ DMSO stock, extract 2–8℃ N₂ dry, anticoag/warfarin/pre-op/pregnancy/lactation/asteraceae-allergy redline on COA.
公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证
☎：19573130018 杨经理（微信同号）
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