长沙上禾生物staherb小白菊内酯Parthenolide产品概述中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

中文产品概述｜Product Overview (CN)

小白菊提取物 / 小白菊内酯 Parthenolide（别名欧苷菊内酯、银胶菊内酯）

植物来源：菊科 Asteraceae 小白菊 Tanacetum parthenium (L.) Sch.Bip.（异名 Chrysanthemum parthenium） 的干燥叶、花蕾及地上部分（非根非种子，花前采收叶含量最高，标提以叶:花蕾 3:1 混合投料）；小白菊内酯是小白菊"预防偏头痛/抗炎"的传统物质基础与唯一标志倍半萜内酯，占植株倍半萜内酯 70%–90%，干叶 0.2%–0.8%、高选育种 1%–2%。

供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®，2010 年长沙麓谷，环创 B8 202，国家高新技术企业，小白菊内酯为抗炎/肿瘤工具分子与医药中间体主力）

化学灵魂：小白菊内酯是小白菊属药材第一标志成分与"抗炎、抗偏头痛、免疫调节"的现代物质基础——单一愈创木烷型倍半萜内酯（sesquiterpene γ-lactone）：系统名 (1aR,7aS,10aS,10bS,E)-1a,5-二甲基-8-亚甲基-2,3,6,7,7a,8,10a,10b-八氢氧杂环丙并[2',3':9,10]环癸[1,2-b]呋喃-9(1aH)-酮（俗称 4,5α-环氧-6β-羟基-愈创木烷-1(10),11(13)-二烯-12-酸 γ-内酯）；分子式 C₁₅H₂₀O₃，MW 248.32，CAS 20554-84-1，EINECS 692-532-0；白色至类白色针状/结晶性粉末（单体）/棕黄至类白粉（提取物），易溶 DMSO（≥100 mg/mL）/乙醇/丙酮/氯仿、微溶于水（LogP≈2.42，水溶是制剂第一难点），mp 115–116℃，[α]ᴅ²⁰ -81.4°（c=1.04, CHCl₃），UV λmax ~205–220 nm（HPLC-UV 220 nm 定量，末端吸收避 254 nm），热/光/碱/环氧开环敏、对空气湿氧渐褐。

药效团本质：两个亲电中心——① α-亚甲基-γ-内酯环 ② 4,5-环氧基，均可对蛋白半胱氨酸 -SH 行 Michael 加成/烷基化，是它不可逆抑 IKKβ(Cys179)/p65(Cys38)/HDAC1 的化学根基；"活性靠亲电、稳定靠避氧碱"是产业核心矛盾。

Staherb 产品定位：双轨柔性——"小白菊标准提取物（偏头痛预防膳食原料/全谱背景）× 高纯小白菊内酯单体（医药中间体/NF-κB 工具分子/对照品）"。保健线守 ESCOP/EMA"传统用于偏头痛预防（非急性发作、非药品）"表述，医药线抛 98%/99% 白晶供 R&D；Staherb 官网明列"Parthenolide 0.2%/0.3%/0.5%/0.8%/1%/2% HPLC-UV@220nm 提取物、90%/95%/98%/99% HPLC 单体白晶、科研级 10 mg–1 g、1/5/25 kg 充氮铝箔、2–8℃ 密封避光（单体 -20℃ 充氮 DMSO 母液）"。

规格矩阵：

• 小白菊标提（Feverfew P.E.）：Parthenolide 0.2%–0.8%（膳食级主轴）、1%–2%（医药中间体/研究级）HPLC-UV@220 nm，60%–75% EtOH 55–65℃ 动态提、喷雾出风≤50℃ 秒干

• 高纯单体轨：90% / 95% / 98% / 99% HPLC-UV@220 nm（白晶），科研级 10 mg–1 g

• 改型选供：氨基酸酯/碳酸酯前药、β-CD 包合、纳米晶、DMAPT 类似物（科研向）

• 伴生背景：樟黄苷/圣菊苷等黄酮、桉叶素/樟脑单萜挥发油、绿原酸——不单独标化

厂区定位：长沙高新麓谷 B8 为小白菊干叶花蕾（欧洲/国内试种基地花前采、≤45℃ 通风干至水分≤8%）→ 除梗 10–20 目→ 60%–75% EtOH 55–65℃ 动态逆流提（禁>70℃ 防内酯开环）→ 板框/离心→ 0.45 μm MF→ AB-8 粗纯或硅胶柱预分→ 制备 HPLC C18 乙腈-水 60:40 @220 nm 切主峰→ 乙醇/乙酸乙酯-石油醚 0–4℃ 重结晶→ Parthenolide 98%/99% 白晶→ 标提喷雾出风≤50℃ 或冻干/真空带干→ 充氮铝箔 2–8℃（单体 -20℃）分装与出口质控中心；干草来自欧洲种源国内试种/进口定点，长沙麓谷 B8 非种植产地（COA 注 "Origin: China-processed / Processed in Changsha, Hunan"）。

概述正文

小白菊内酯是把"菊科小白菊里的愈创木烷倍半萜内酯"护环氧提纯与避光充氮稳化的典型——Staherb 不卖模糊小白菊粗粉，而是把花前干叶经低温醇提（避>65℃ 防 α-亚甲基-γ-内酯差向/环氧水解）、AB-8 或硅胶把叶绿素/黄酮/单萜切掉、60%–75% 乙醇把 Parthenolide 富集、制备 HPLC/重结晶抛到 99% 白晶、全程≤65℃ 提/≤50℃ 减浓/≤50℃ 喷干/避光充氮防环氧亲电失活，按终端反向派单：① 偏头痛预防膳食（最成熟主场）——0.2%–0.5% 标提 100–300 mg/日（递送 Parthenolide 0.2–0.7 mg/日），配镁/B2/CoQ10 作"自然预防栈"，ESCOP/EMA 传统用途背景、Cochrane 结论不一、连续≥3 月评估，不叫卖"治偏头痛"；② 抗炎辅助——配姜黄素/波尔定入关节/经期不适背景，IKKβ/NF-κB/TNF-α 背景；③ 医药 R&D 与对照品（高纯主轴）——98%/99% 单体作 NF-κB/IKKβ 共价抑制阳性对照、HDAC1/STAT3 工具分子、肿瘤干细胞（CD44+/CD24-）凋亡临床前底物，附 HPLC-UV@220nm+LC-MS+¹H NMR；④ 化妆品舒缓——0.1%–0.5% 入抗红精华（抗炎 ROS 背景，注意 H317 接触致敏与光敏）；⑤ 兽药——极少用。在长沙高新麓谷 B8 报"Parthenolide HPLC-UV@220 nm（乙腈-水 60:40，Parthenolide CRS 外标，Rt 附）+ 伴生樟黄苷/圣菊苷同检 + 水分≤5%(单体) + 环氧有关物质（开环 Parthenolide 衍生物≤1%）+ 重金属(Pb≤0.5/Cd≤0.3/As≤1 ppm 药用严限) + 农残(GB2763+EU396) + 溶剂残留（EtOH/EtOAc/MeCN/石油醚 ICH Q3C）+ 微生物 + 40℃/75%RH 6 月加速"。产品定位于菊科小白菊干燥叶花蕾中单一愈创木烷倍半萜内酯（C15H20O3、mp 115–116℃、[α]ᴅ -81.4°、α-亚甲基-γ-内酯+4,5-环氧双亲电、干叶 0.2%–0.8% DW）的偏头痛预防背景膳食配料与 NF-κB 工具分子；原料页仅作"sesquiterpene lactone from Tanacetum parthenium, α-methylene-γ-lactone+4,5-epoxide electrophilic warhead, ESCOP/EMA traditional migraine-prophylaxis background, NF-κB/IKKβ covalent modifier"；不跨境宣称治疗偏头痛急性发作/类风湿/白血病/乳腺癌（属药品范畴），偏头痛预防为 ESCOP/EMA 传统用途+临床证据不一背景、抗炎/抗肿瘤为细胞动物与临床前背景；微水溶、热光碱敏、环氧亲电 H317 致敏，单体 -20℃ 避光充氮 DMSO 母液、标提 2–8℃ 充氮防潮，抗凝/华法林/术前/妊娠哺乳/菊科过敏红线 COA 必注。

English Product Overview｜EN

Feverfew Extract / Parthenolide (syn. tanacetin lactone, (1aR,7aS,10aS,10bS,E)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-9(1aH)-one)

Botanical source: Dried leaves, flower buds & aerial parts of Asteraceae Tanacetum parthenium (L.) Sch.Bip. (syn. Chrysanthemum parthenium) (not root/seed; pre-flower leaf highest, feed leaf:bud 3:1); parthenolide is the sole marker-active sesquiterpene lactone and modern substance-base of feverfew "migraine-prophylaxis/anti-inflam", 70–90% of plant sesquiterpene lactones, dry leaf 0.2–0.8%, selected cultivars 1–2%.

Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®, founded 2010 Changsha Lugu B8-202, national hi-tech, parthenolide as anti-inflam/oncology tool-molecule & API-intermediate line)

Chemical soul: Parthenolide is the first marker and modern basis of "anti-inflam / migraine-prophylaxis / immune-mod" in T. parthenium — one guaiane-type sesquiterpene γ-lactone: common name 4,5α-epoxy-6β-hydroxy-germacra-1(10),11(13)-dien-12-oic acid γ-lactone; formula C₁₅H₂₀O₃, MW 248.32, CAS 20554-84-1, EINECS 692-532-0; white-to-off-white needle/crystal (monomer) / tan-to-pale powder (extract), freely DMSO (≥100 mg/mL) / EtOH / acetone / CHCl₃, poorly water (LogP≈2.42, aqueous solubility is formulation #1 hurdle), mp 115–116℃, [α]ᴅ²⁰ -81.4° (c=1.04, CHCl₃), UV λmax ~205–220 nm (HPLC-UV 220 nm quant, end-absorption avoid 254 nm), heat/light/base/epoxide-open sensitive, air-moist oxidizes brown.

Warhead essence: two electrophilic centers — ① α-methylene-γ-lactone ring ② 4,5-epoxide, both Michael-add/alkylate protein cysteine -SH, chemical root of irreversible IKKβ(Cys179)/p65(Cys38)/HDAC1 inhibition; "activity from electrophile, stability from O₂/base avoidance" is industrial core contradiction.

Staherb positioning: dual-track flexible — "feverfew standardized extract (migraine-prophylaxis dietary raw / full-spectrum background) × high-pure parthenolide monomer (API-intermediate / NF-κB tool / reference)". Nutra line obeys ESCOP/EMA "traditional use for migraine prophylaxis (not acute, not drug)" wording, pharma line polishes 98/99% white crystal for R&D; Staherb site: "Parthenolide 0.2/0.3/0.5/0.8/1/2% HPLC-UV@220nm extract, 90/95/98/99% HPLC monomer, research 10mg–1g, 1/5/25kg N₂-foil, 2–8℃ dark (monomer -20℃ N₂ DMSO stock)".

Spec matrix:

• Feverfew P.E.: Parthenolide 0.2–0.8% (dietary spine), 1–2% (API-intermediate/research) HPLC-UV@220nm, 60–75%EtOH 55–65℃ dynamic counter-current, spray outlet≤50℃

• High-pure monomer: 90% / 95% / 98% / 99% HPLC-UV@220nm (white crystal), research 10 mg–1 g

• Modified opt: amino-ester/carbamate prodrug, β-CD inclusion, nanocrystal, DMAPT analog (R&D)

• Companions: tanetin/santonin-like flavonoids, eucalyptol/camphor monoterpenes, chlorogenics — not individually standardized

Site role: Changsha Lugu B8 = feverfew dry leaf-bud (European-cultivar domestic trial/imported registered, pre-flower cut, ≤45℃ vent-dry moisture≤8%) → de-stem 10–20 mesh → 60–75%EtOH 55–65℃ dynamic counter-current (forbid >70℃ lactone-open) → plate/centrifuge → 0.45μm MF → AB-8 rough or silica pre-split → prep-HPLC C18 MeCN-H₂O 60:40 @220nm cut main-peak → EtOH/EtOAc-petroleum 0–4℃ recryst → parthenolide 98/99% white crystal → std spray outlet≤50℃ or FD/vac-band-dry → N₂-foil 2–8℃ (monomer -20℃) repack & export QC center; dry herb from EU-cultivar domestic/import base, Changsha Lugu B8 not plantation (COA "Origin: China-processed / Processed in Changsha, Hunan").

Overview body

Parthenolide is the typical case of industrializing "guaiane sesquiterpene lactone from feverfew" with epoxide protection and N₂ stabilization — Staherb doesn't sell vague feverfew crude, but pre-flower dry leaf low-temp EtOH extract (avoid >65℃ α-methylene-γ-lactone epimer/epoxide hydrolyze), AB-8/silica cuts chlorophyll/flavonoid/monoterpene, 60–75% EtOH enriches parthenolide, prep-HPLC/recryst polishes 99% white crystal, whole line ≤65℃ extract / ≤50℃ conc / ≤50℃ spray / dark N₂ prevent electrophilic deactivation, reverse-dispatch: ① migraine prophylaxis dietary (most mature home) — 0.2–0.5% std 100–300 mg/day (deliver 0.2–0.7 mg parthenolide/day), blend Mg/B2/CoQ10 "natural preventive stack", ESCOP/EMA traditional-use background, Cochrane mixed, assess ≥3 mo, not "treats migraine"; ② anti-inflam adjunct — with curcumin/boron for joint/menstrual background, IKKβ/NF-κB/TNF-α background; ③ pharma R&D & reference (high-pure spine) — 98/99% monomer as NF-κB/IKKβ covalent-positive control, HDAC1/STAT3 tool, cancer-stem-cell (CD44+/CD24-) apoptose preclinical substrate, HPLC-UV@220nm+LC-MS+¹H NMR attached; ④ cosmetic soothing — 0.1–0.5% anti-red serum (anti-inflam ROS background, note H317 contact-sensitize & photosens); ⑤ vet — rarely. At Changsha Lugu B8 report "Parthenolide HPLC-UV@220nm (MeCN-H₂O 60:40, parthenolide CRS ext, Rt attached) + companion tanetin/santonin same-check + moisture≤5%(monomer) + epoxide-related (open-ring deriv ≤1%) + heavy(drug Pb≤0.5/Cd≤0.3/As≤1 ppm) + pesticide(GB2763+EU396) + solvent(EtOH/EtOAc/MeCN/pet-ether ICH Q3C) + microbe + 40℃/75%RH 6mo accel". Positioned as single guaiane sesquiterpene lactone from Tanacetum parthenium dried leaf-bud (C15H20O3, mp115–116℃, [α]ᴅ -81.4°, α-methylene-γ-lactone+4,5-epoxide dual-electrophile, dry leaf 0.2–0.8% DW) migraine-prophylaxis-background dietary ingredient & NF-κB tool-molecule; label only "sesquiterpene lactone from T. parthenium, α-methylene-γ-lactone+4,5-epoxide electrophilic warhead, ESCOP/EMA traditional migraine-prophylaxis background, NF-κB/IKKβ covalent modifier"; no cross-border treat-acute-migraine/RA/AML/breast-cancer claim (drug scope), migraine-prophylaxis ESCOP/EMA traditional + mixed clinical + anti-inflam/anticancer cell-animal/preclinical background only; poorly water, heat/light/base-sensitive, epoxide electrophile H317 sensitization, monomer -20℃ dark N₂ DMSO stock, extract 2–8℃ N₂ dry, anticoag/warfarin/pre-op/pregnancy/lactation/Asteraceae-allergy redline on COA.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）