长沙上禾生物staherb小白菊内酯Parthenolide应用领域中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

中文应用领域｜Application Fields (CN)

产品：小白菊提取物 / 小白菊内酯 Parthenolide（C₁₅H₂₀O₃，CAS 20554-84-1，菊科小白菊 Tanacetum parthenium 叶花蕾愈创木烷型倍半萜内酯，α-亚甲基-γ-内酯+4,5-环氧双亲电中心，HPLC 220 nm）

供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®，2010 年长沙麓谷，环创 B8 202）

规格—应用对应（Staherb 分级供应）：

• 小白菊标提（Feverfew P.E.）：Parthenolide 0.2%–0.8%（膳食级主轴）、1%–2%（医药中间体/研究级）HPLC-UV@220 nm，60%–75% EtOH 55–65℃ 提、喷雾出风≤50℃

• 高纯单体轨：90% / 95% / 98% / 99% HPLC-UV@220 nm（白晶），科研级 10 mg–1 g

• 改型选供：DMAPT（二甲氨基 Parthenolide）/氨基酸酯前药/β-CD 包合/纳米晶（医药研发探索）

• 伴生背景：黄酮（樟黄苷/圣菊苷）、单萜挥发油（桉叶素/樟脑）、绿原酸——不单独标化

  合规锚点：小白菊为 ESCOP/EMA/HMPC 认可"传统用于偏头痛预防"草药（非急性止痛替代曲普坦），临床循证要求标提 Parthenolide≥0.2%、日摄 0.2–0.7 mg、连服≥3 月；Cochrane 评混合结论、EFSA 未给单独 ADI、美国按 DSHEA 老原料走；原生 Parthenolide 微溶于水、热光碱敏、环氧亲电 H317 皮肤致敏，抑血小板 5-HT 释放背景→抗凝/华法林/阿司匹林联用问医、术前 1–2 周停、妊娠哺乳禁用、菊科过敏慎用、长期嚼鲜叶致口疮；Staherb 核心原则"低纯标提走'吃和抹'（保健/化妆）、高纯单体走'研和治'（医药 R&D/对照品）+ 不跨境宣称治疗偏头痛急性发作/AML/类风湿"。

核心应用板块

1. 膳食补充剂——偏头痛预防（最成熟商业主场）

• 预防胶囊/片剂：0.2%–0.5% 标提 100–300 mg/日（递送 Parthenolide 0.2–0.7 mg/日），配镁/B2/CoQ10 作"自然预防栈"，连续 3–4 月评估发作频率/严重度（Meta 约降 24%–32%），不是急性发作 abortive 替代；去 Parthenolide 的贫内酯小白菊无效。

• 关节抗炎辅助：配姜黄/乳香入类风湿/骨关节炎背景复方，NF-κB/TNF-α/IL-6 背景，非一线抗炎药替代。

• 经期不适/神经血管背景：女性经期头痛背景、脑健康滴剂（神经炎症背景，仅辅助营养研究）。

2. 医药研发与新药中间体（高纯主轴）

• 98%/99% 单体作 NF-κB/IKKβ 共价抑制阳性对照、HDAC1/STAT3 工具分子，RAW264.7/LPS 炎症、AML CD34+ 原代、乳腺癌 CD44+/CD24-、胶质瘤、胰腺癌细胞动物模型底物，附 HPLC-UV@220nm+LC-MS+¹H NMR；

• 先导化合物与半合成：以 PTL 为母核的 DMAPT（二甲氨基 Parthenolide，水溶改良）进 AML/胶质瘤 I 期、ACT001（MicuRx/尚德）脑胶质瘤临床——Staherb 单体供起始物料/中间体，不宣称终端疗效；

• 抗纤维化筛选：TGF-β1/Smad 抑制用于肺/肝/肾纤维化药物发现背景。

3. 功效护肤与敏感肌舒缓（日化双刃盘）

• 抗红舒缓精华/面霜/晒后修护：0.1%–0.5% 标提或中纯单体（≥95% 需降浓），抑 COX-2/IL-6/ROS 改善泛红刺痛、玫瑰痤疮背景；α-亚甲基-γ-内酯具 H317 接触致敏，配方师需做斑贴、敏感肌建议用"脱 Parthenolide 小白菊提取物"（留黄酮去内酯）避险；

• 抗痘辅助：抑皮脂腺炎症、红肿痘背景，非强效抗菌；

• 头皮舒缓：头皮泛红瘙痒背景（同 H317 警示）。

4. 功能性食品与茶饮（边缘）

• 标提入功能压片糖果/固体饮料作"清血管炎性背景"配料；家庭自煮小白菊茶无法保证 PTL 含量与热稳定性（>70℃ 内酯开环），Staherb 不建议替代标提胶囊。

5. 科研对照与教学试剂

• ≥98% 作 HPLC 220 nm 外标、NF-κB 通路教学演示、有机化学倍半萜内酯 Michael 加成实验底物，10 mg–1 g 棕瓶 -20℃ 充氮 DMSO 母液分装。

6. 兽药与饲料（极少）

• 偶见于赛马/犬抗炎探索，非 Staherb 主推，农残重金属按出口畜规另议。

明确边界（Staherb 不碰）

• "Parthenolide 治急性偏头痛/白血病/类风湿/阿尔茨海默"等药品级跨境宣称（仅 ESCOP 传统预防+细胞动物/临床前）；

• 标提不标 Parthenolide 含量（<0.2% 或只写"小白菊提取物"模糊出货）；

• 化妆品不加敏警、标提直接 1%–2% 入面霜致接触皮炎；

• 忽视抗凝/妊娠/菊科过敏红线未在 COA 注；

• 鲜叶嚼服式"天然用法"引导（口疮/味觉障碍）。

⚠️ Staherb 合规边界：原料页统一表述"Parthenolide (CAS 20554-84-1, C₁₅H₂₀O₃) as sesquiterpene lactone from Tanacetum parthenium aerial leaf-bud, α-methylene-γ-lactone+4,5-epoxide electrophilic warhead, NF-κB/IKKβ covalent tool; ESCOP/EMA traditional migraine-prophylaxis (not acute), 0.2–0.7 mg/day from ≥0.2% std ≥3 mo; poorly water, heat/light/base-sensitive, H317 sensitization, anticoag/pre-op/pregnancy/lactation/Asteraceae-allergy redline"；单体 -20℃ 避光充氮 DMSO 母液、标提 2–8℃ 充氮防潮。

English Application Fields｜EN

Product: Feverfew Extract / Parthenolide (syn. tanacetin lactone, guaiane sesquiterpene γ-lactone from Asteraceae Tanacetum parthenium leaf-bud, CAS 20554-84-1, C₁₅H₂₀O₃)

Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®, Changsha Lugu B8-202, since 2010)

Spec↔App map (Staherb tiered):

• Feverfew P.E.: Parthenolide 0.2–0.8% (dietary spine), 1–2% (API-intermediate/research) HPLC-UV@220nm, 60–75%EtOH 55–65℃, spray outlet≤50℃

• High-pure monomer: 90% / 95% / 98% / 99% HPLC-UV@220nm (white crystal), research 10 mg–1 g

• Modified opt: DMAPT / amino-ester prodrug / β-CD inclusion / nanocrystal (pharma R&D)

• Companions: tanetin/santonin-like flavonoids, eucalyptol/camphor monoterpenes, chlorogenics — not individually standardized

  Compliance anchor: feverfew is ESCOP/EMA/HMPC "traditional use for migraine prophylaxis" herb (NOT acute abortive vs triptans), clinical bar = std extract Parthenolide≥0.2%, 0.2–0.7 mg/day, ≥3 mo continuous; Cochrane mixed, EFSA no separate ADI, US DSHEA legacy; native parthenolide poorly water, heat/light/base-sensitive, epoxide electrophile H317 skin-sensitize, inhibits platelet 5-HT release → anticoag/warfarin/aspirin consult, stop 1–2 wk pre-op, pregnancy/lactation contraindicated, Asteraceae-allergy caution, fresh-leaf chew causes mouth ulcer; Staherb core "low-pure std for 'ingest & topical' (nutra/cosmetic), high-pure monomer for 'research & drug' (pharma R&D/ref), no cross-border treat-acute-migraine/AML/RA".

Key Application Fields

1. Nutraceutical — migraine prophylaxis (most mature commercial home)

• Prophylaxis cap/tab: 0.2–0.5% std 100–300 mg/day (deliver 0.2–0.7 mg parthenolide/day), blend Mg/B2/CoQ10 "natural preventive stack", assess 3–4 mo for frequency/severity (Meta ~24–32% drop), not acute abortive substitute; parthenolide-depleted feverfew inert.

• Joint anti-inflam adjunct: with curcumin/boswellia for RA/OA background, NF-κB/TNF/IL-6 background, not first-line NSAID replace.

• Menstrual/neurovascular background: menstrual-headache background, brain-health drops (neuroinflam background, nutritive only).

2. Pharma R&D & API-intermediate (high-pure spine)

• 98/99% monomer as NF-κB/IKKβ covalent-positive control, HDAC1/STAT3 tool, RAW264.7/LPS, primary AML CD34+, breast CD44+/CD24-, glioma, pancreatic cell-animal substrate, HPLC-UV@220nm+LC-MS+¹H NMR attached;

• Lead & semisynth: PTL-scaffold DMAPT (dimethylaminoparthenolide, water-soluble) in AML/glioma Phase I, ACT001 in glioblastoma clinical — Staherb monomer as starting-material/intermediate, no endpoint efficacy claim;

• Anti-fibrosis screen: TGF-β1/Smad inhibit for pulmonary/hepatic/renal fibrosis drug-discovery background.

3. Cosmetic & sensitive-skin soothing (dermo double-edge)

• Anti-red serum/cream/post-sun: 0.1–0.5% std or mid-pure monomer (≥95% must dilute), COX-2/IL-6/ROS↓ for redness/sting/rosacea background; α-methylene-γ-lactone is H317 contact-sensitizer, formulators must patch-test, sensitive-skin better served by "parthenolide-depleted feverfew extract" (keep flavonoid drop lactone);

• Anti-acne adjunct: sebaceous inflam↓, red-pimple background, not strong antimicrobial;

• Scalp soothing: scalp red-itch background (same H317 caution).

4. Functional food & tea (marginal)

• Std extract in functional chew-tab/solid drink as "vascular-inflam background" ingredient; home-brewed feverfew tea cannot guarantee PTL content & thermal-stability (>70℃ lactone-open), Staherb advises not replace std cap.

5. R&D reference & teaching reagent

• ≥98% as HPLC 220nm external, NF-κB-pathway demo, organic-chem sesquiterpene Michael-addition substrate, 10 mg–1 g amber -20℃ N₂ DMSO stock.

6. Vet & feed (rare)

• Occasional equine/canine anti-inflam explore, not Staherb main push, export vet-regulation separate.

Explicit boundary (Staherb refuses)

• "Parthenolide treats acute migraine/AML/RA/Alzheimer" drug-level cross-border claim (only ESCOP traditional-prophylaxis + cell-animal/preclinical);

• Std extract not reporting Parthenolide % (<0.2% or vague "feverfew extract" only);

• Cosmetic without sensitization warning, std 1–2% straight into face cream causing contact dermatitis;

• Ignore anticoag/pregnancy/Asteraceae-allergy redline on COA;

• Promote fresh-leaf chew "natural use" (mouth ulcer/taste disorder).

Supplier note: Staherb labels "Parthenolide (CAS 20554-84-1, C₁₅H₂₀O₃) as sesquiterpene lactone from Tanacetum parthenium aerial leaf-bud, α-methylene-γ-lactone+4,5-epoxide electrophilic warhead, NF-κB/IKKβ covalent tool; ESCOP/EMA traditional migraine-prophylaxis (not acute), 0.2–0.7 mg/day from ≥0.2% std ≥3 mo; poorly water, heat/light/base-sensitive, H317 sensitization, anticoag/pre-op/pregnancy/lactation/Asteraceae-allergy redline"; monomer -20℃ dark N₂ DMSO stock, extract 2–8℃ N₂ dry.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）