长沙上禾生物staherb小白菊内酯Parthenolide原料产地中英文简介

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）

中文原料产地｜Raw Material Origin (CN)

产品：小白菊提取物 / 小白菊内酯 Parthenolide（C₁₅H₂₀O₃，CAS 20554-84-1，菊科 Asteraceae 小白菊 Tanacetum parthenium (L.) Sch.Bip. 叶及花蕾愈创木烷型倍半萜内酯）

供应商：长沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb®，2010 年长沙麓谷，环创 B8 202，国家高新技术企业）

植物基源与种源：小白菊内酯只从菊科小白菊 Tanacetum parthenium（异名 Chrysanthemum parthenium）的叶与花蕾提，不从茎/根/种子提（Planta Med 1997 明载茎部 PTL 近零、盛花后老叶降至 0.1% 以下）；严格排除杭白菊/桐乡小白菊/钮扣菊等茶用观赏菊、野生近缘艾菊 T. vulgare 充数——后者或无 PTL 或伴生青蒿素类混伪。同株伴生樟黄苷/圣菊苷等黄酮、桉叶素/樟脑单萜挥发油、绿原酸，PTL 占倍半萜内酯 70%–90%，是 ESCOP/EMA 唯一定量标记。含量季节窗：叶部 PTL 在抽茎前幼苗期最高，花蕾期叶 0.50% DW、盛花全草（叶+花蕾+少量梗）0.20% DW 为欧标双档（Planta Med 1997）；西北引种盛花前叶 0.3%–0.6%、花蕾富集批 0.8%–1.2% 文献窗。

Staherb 产地策略（"国产西北高海拔主轴 + 欧洲传统源定制 + 西南引种零星调剂"双轨定点）

Staherb 采用"公司+引种基地+备案"订单农业：在小白菊道地/适生带建分株繁苗（3–4 芽/株、滴灌、生物防蚜）备案基地→盛花前（6–7 月）采上部叶+花蕾（叶:蕾≈3:1）→除梗→≤45℃ 通风阴干或冻干至水分≤8%→密封运长沙，麓谷 B8 仅做低温醇提→AB-8/硅胶→制备 HPLC/重结晶→标化分装，非种植产地（COA 注 "Origin: China / Processed in Changsha, Hunan" 或 "EU-origin processed in Changsha"）。多源策略规避单产区气候波动，保工业批 PTL 基线稳（投料优选干叶 PTL≥0.3%–0.5% DW，花蕾富集批≥0.8%）。

核心产区与投料特点

• 主供主轴｜国产西北高海拔带（新疆伊犁/巩留、甘肃酒泉/张掖、陕西宝鸡/太白/延安）：海拔 800–1500 m、年日照 2600–3000 h、昼夜温差 12–15℃、砂壤 pH 6.5–7.5，引种 T. parthenium 后叶部 PTL 干重 0.3%–0.6%、花蕾期峰值 0.8%–1.2% 文献窗，极利倍半萜内酯积累；Staherb 在此建 GAP 式备案基地（分株繁苗、苏云金杆菌防蚜、禁硫熏），标准提取物 0.2%–2% 主线占投料 ≥60%，成本优供应稳、含量可锁定，是 0.2%–0.8% 膳食级与 1%–2% 研究级的主力前体。

• 定制 B｜欧洲传统源（英国肯特/苏塞克斯、保加利亚罗多普、巴尔干引种田）：小白菊原生地，客户主打"European traditional feverfew / ESCOP-EMA monograph"概念或需欧源溯源时启用；英国肯特产干叶 PTL 0.2%–0.5%、保加利亚罗多普 0.3%–0.6%，仅定制批不进国产主轴，成本较高、溯源文件全（有机/非转基因/收获年）。

• 西南零星调剂｜云南漾濞/大理高海拔引种（800–2000 m 向阳坡）：国内已有栽培种群，作西南双源零星调剂非主轴；伴生挥发油组分略异，入厂严控伴生单萜比。

• 拒收红线：杭白菊/桐乡小白菊/钮扣菊等菊科茶用观赏混伪、野生近缘 T. vulgare（艾菊）充数、盛花后老叶（PTL<0.1% DW）、未分级全草（梗拉低均值）、硫熏（SO₂>150 mg/kg）、霉变虫蛀、农残 47 项超标、>80℃ 直火烘致 α-亚甲基-γ-内酯开环、陈货（存>2 年光降）、水分>8%。

采收与初制窗口

• 盛花前 6–7 月采上部叶+花蕾（叶:蕾≈3:1）→ 除梗 → ≤45℃ 通风阴干或冻干至水分≤8%（Planta Med 1997 证实常温干/冻干对 PTL 单株得率无负影响，忌 >80℃ 直火烘致内酯开环）→ 打捆/粉碎前分级；每批附基原（T. parthenium 显微+TLC）、产区（到县）、播期、采期（到旬）、部位（叶/花蕾/比）、干法、初水分、初 PTL（HPLC-UV@220 nm）、初伴生樟黄苷%、农残批号、基地备案号**。

• Staherb 入厂拒收：陈货（存>2 年）、硫熏、艾菊/杭白菊未声明混入、全草未除梗、干叶 PTL<0.3% DW、TLC 基原不符。

入厂基线（Staherb 快检红线）

• 干原料：水分≤8%、总灰≤8%、酸不溶灰≤1.5%、SO₂≤150 mg/kg；

• Parthenolide（HPLC-UV@220 nm，乙腈-水 60:40，PTL CRS 外标）≥0.3%–0.5% DW（优选批≥0.5%，花蕾富集批≥0.8%，拒<0.2%）；

• 伴生樟黄苷/圣菊苷同检（背景值，不单独标化）；

• 重金属：Pb≤0.5 ppm（药用严限）/Cd≤0.3 ppm/As≤1 ppm/Cu≤10 ppm；

• 农残：GB 2763 + 欧盟 396/2005 + 日本肯定列表（菊科严检有机磷/菊酯/除草剂 47 项）；

• 感官：叶碎墨绿、花蕾黄白、特异草本气味、无焦糊味。

溯源双向链

干料批：附省/县（新疆伊犁/巩留、甘肃酒泉/张掖、陕西宝鸡/太白、英国 Kent、保加利亚 Rhodope）/基原（T. parthenium 显微 TLC）/播期/采期（2025-06 盛花前）/部位（叶:蕾 3:1）/干法/初水分/初 PTL%/初樟黄苷%/农残批号/基地备案号；Staherb 单体批号 ↔ 干料批号 ↔ 初制厂备案号三级双向**，COA 可追到"新疆伊犁巩留 2025-06 盛花前叶:蕾 3:1、初 PTL 0.62% DW → 60% EtOH 60℃ 提 → AB-8 60% EtOH 洗脱 → 制备 HPLC C18 220 nm → 0–4℃ 重结晶 → Parthenolide 98.7% HPLC + 环氧开环物 0.4% + mp 115℃"。

⚠️ Staherb 合规边界：原料页表述"dried leaf & flower-bud of Asteraceae Tanacetum parthenium (L.) Sch.Bip. (NOT Chrysanthemum morifolium Hangbaiju / T. vulgare tansy), PTL only in leaf+bud not stem; multi-source registered NW-China Xinjiang-Gansu-Shaanxi ≥800m altitude primary + UK/Bulgaria European custom + Yunnan SW roll-adjust; Changsha Lugu B8 = low-temp EtOH extract + AB-8/silica + prep-HPLC recryst standardize-repack center NOT plantation"；所有出口批附 "Parthenolide HPLC-UV@220nm (MeCN-H₂O 60:40, CRS ext), pre-flower leaf-bud harvest, dry≤45℃ not >80℃ open-fire, ESCOP/EMA traditional feverfew source, poorly water heat/light/base-sensitive H317, 2–8℃ N₂ dry monomer -20℃ N₂"；不跨境宣称治疗偏头痛急性发作/白血病。

English Raw Material Origin｜EN

Product: Feverfew Extract / Parthenolide (guaiane sesquiterpene γ-lactone from Asteraceae Tanacetum parthenium (L.) Sch.Bip. leaf & flower-bud, CAS 20554-84-1, C₁₅H₂₀O₃)

Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb®, Changsha Lugu B8-202, since 2010)

Botanical source & germplasm: Parthenolide only from leaf & flower-bud of Tanacetum parthenium (syn. Chrysanthemum parthenium), NEVER stem/root/seed (Planta Med 1997: stem PTL ~zero, post-full-bloom old leaf <0.1%); strictly excludes Chrysanthemum morifolium Hangbaiju / button-chrysanthemum (tea-ornamental) and wild T. vulgare tansy — latter no PTL or adulterate with artemisinin-type. Companions tanetin/santonin-like flavonoids, eucalyptol/camphor monoterpenes, chlorogenics; PTL 70–90% of sesquiterpene lactones, sole ESCOP/EMA quant marker. Season window: leaf PTL highest pre-stem-elongation, leaf-at-bud-stage 0.50% DW / full-bloom herb 0.20% DW (Planta Med 1997 two-tier EU standard); NW-China introduced leaf 0.3–0.6%, bud-enriched batch 0.8–1.2% literature window.

Staherb origin strategy ("NW-China high-altitude primary + European traditional custom + SW-Yunnan roll-adjust" dual-track registered)

Staherb runs "company+introduced-base+registry" order-farming: fixed registered divide-rhizome nursery (3–4 buds/plant, drip-irrigation, Bt aphid-control) bases → pre-full-bloom (Jun–Jul) cut upper leaf+flower-bud (leaf:bud≈3:1) → de-stem → ≤45℃ vent-shade or FD moisture≤8% → sealed to Changsha, Lugu B8 only low-temp EtOH extract → AB-8/silica → prep-HPLC/recryst → standardize-repack, NOT plantation (COA "Origin: China / Processed in Changsha, Hunan" or "EU-origin processed in Changsha"). Multi-source avoids single-region swing, keeps industrial PTL baseline steady (feed pref dry-leaf ≥0.3–0.5% DW, bud-enriched ≥0.8%).

Core regions & feed traits

• Primary spine｜NW-China high-altitude belt (Xinjiang Yili/Gongliu, Gansu Jiuquan/Zhangye, Shaanxi Baoji/Taibai/Yan'an): 800–1500 m, 2600–3000 h sun/yr, ΔT 12–15℃, sandy pH 6.5–7.5, introduced T. parthenium leaf PTL 0.3–0.6% DW, bud-stage peak 0.8–1.2% literature window, ideal for sesquiterpene accumulate; Staherb GAP-style registered (divide-rhizome, Bt, no SO₂), std extract 0.2–2% main line ≥60% feed, cost-steady, 0.2–0.8% dietary + 1–2% research primary precursor.

• Custom B｜European traditional (UK Kent/Sussex, Bulgaria Rhodope, Balkan introduced fields): feverfew native source, for "European traditional feverfew / ESCOP-EMA monograph" traceability only; UK Kent dry-leaf PTL 0.2–0.5%, Bulgaria Rhodope 0.3–0.6%, custom-only not in CN-spine, higher cost, full cert (organic/non-GMO/harvest-year).

• SW roll-adjust｜Yunnan Yangbi/Dali introduced (800–2000 m sunny slope): domestic cultivated population, minor SW dual-source adjust not spine; companion monoterpene ratio slightly off, inbound strict.

• Reject gates: C. morifolium Hangbaiju/button-chrysanthemum ornamental admix, wild T. vulgare tansy, post-full-bloom old leaf (PTL<0.1% DW), ungraded whole-herb (stem dilutes), SO₂-bleach(>150mg/kg), mold/insect, 47-pesticide over, >80℃ open-fire bake lactone-open, aged>2yr photo-drop, moisture>8%.

Harvest & primary-process

• Pre-full-bloom Jun–Jul cut upper leaf+flower-bud (leaf:bud≈3:1) → de-stem → ≤45℃ vent-shade or FD moisture≤8% (Planta Med 1997 confirms ambient-dry/FD no negative vs fresh on per-plant PTL yield, forbid >80℃ open-fire lactone-open) → bundle/pre-mill grade; each lot with basorigin (T. parthenium micro+TLC) + county-origin + sow-year + harvest(10-day) + part(leaf/bud/ratio) + dry-mode + initial moisture + initial PTL (HPLC-UV@220nm) + initial tanetin% + pesticide lot + base-reg**.

• Staherb rejects aged>2yr, SO₂-bleached, tansy/Hangbaiju undeclared, undegstemmed whole-herb, dry-leaf PTL<0.3% DW, TLC mismatch.

Inbound baseline (Staherb quick-test redline)

• Dry material: moisture≤8%, total-ash≤8%, acid-insol-ash≤1.5%, SO₂≤150 mg/kg;

• Parthenolide (HPLC-UV@220nm, MeCN-H₂O 60:40, PTL CRS ext) ≥0.3–0.5% DW (pref≥0.5%, bud-enriched≥0.8%, reject<0.2%);

• Companion tanetin/santonin flavonoids same-check (background, not standardized);

• Heavy: Pb≤0.5ppm (drug strict)/Cd≤0.3/As≤1/Cu≤10;

• Pesticide: GB 2763 + EU 396/2005 + JP pos-list (Asteraceae tight organophosphorus/pyrethroid/herbicide 47-item);

• Sensory: dark-green leaf碎片, yellow-white bud, characteristic herbal note, no scorched.

Genealogy bidirectional chain

Dry-lot: with province/county (Xinjiang Yili/Gongliu, Gansu Jiuquan/Zhangye, Shaanxi Baoji/Taibai, UK Kent, Bulgaria Rhodope) / basorigin (T. parthenium micro+TLC) / sow-year / harvest (2025-06 pre-full-bloom) / part (leaf:bud 3:1) / dry-mode / initial moisture / initial PTL% / initial tanetin% / pesticide lot / base-reg**; Staherb monomer lot ↔ dry-lot ↔ primary-plant reg 3-tier bidirectional, COA traceable to "Xinjiang Yili Gongliu 2025-06 pre-full-bloom leaf:bud 3:1, initial PTL 0.62% DW → 60%EtOH 60℃ → AB-8 60%EtOH → prep-HPLC C18 220nm → 0–4℃ recryst → parthenolide 98.7% HPLC + epoxide-open 0.4% + mp 115℃".

Supplier note: Staherb labels "dried leaf & flower-bud of Asteraceae Tanacetum parthenium (L.) Sch.Bip. (NOT Chrysanthemum morifolium Hangbaiju / T. vulgare tansy), PTL only in leaf+bud not stem; multi-source registered NW-China Xinjiang-Gansu-Shaanxi ≥800m altitude primary + UK/Bulgaria European custom + Yunnan SW roll-adjust; Changsha Lugu B8 = low-temp EtOH extract + AB-8/silica + prep-HPLC recryst standardize-repack center NOT plantation"; every export lot carries "Parthenolide HPLC-UV@220nm (MeCN-H₂O 60:40, CRS ext), pre-flower leaf-bud harvest, dry≤45℃ not >80℃ open-fire, ESCOP/EMA traditional feverfew source, poorly water heat/light/base-sensitive H317, 2–8℃ N₂ dry monomer -20℃ N₂"; no cross-border treat-acute-migraine/AML claim.

公司官网 http://www.staherb.com/ 资质:HALAL, KOSHER等认证

☎：19573130018 杨经理（微信同号）