文章标题:Genetic polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and risk of vitiligo in Han Chinese populations: a genotype–phenotype correlation study
影响因子:4.1
期刊:BRITISH JOURNAL OF DERMATOLOGY
作者列表:Chen J.‐X., Shi Q., Wang X.‐W., Guo S., Dai W., Li K., Song P., Wei C., Wang G., Li C.‐Y., Gao T.‐W.
发表时间:2014-5-1
DOI:10.1111/bjd.12845
主要研究成果:Summary
Background
Recent evidence has revealed an elevation of total homocysteine (tHcy) in patients with vitiligo. Methylenetetrahydrofolate reductase (MTHFR) is one of the main enzymes regulating homocysteine (Hcy) metabolism. Thus, polymorphisms of MTHFR could potentially contribute to the development of vitiligo by affecting MTHFR activity and tHcy levels.