蒿本内酯(Ligustilide)长沙上禾生物中英文简介

产品名称

蒿本内酯 (藁本内酯)

Ligustilide

化学描述

一种重要的苯酞类化合物 (Phthalide)，是伞形科药用植物（如当归、川芎）的主要挥发性活性成分，也是其特有香气的主要来源。

An important phthalide compound, the main volatile active ingredient in Apiaceae medicinal plants (e.g., Angelica sinensis, Ligusticum chuanxiong), and the primary source of their characteristic aroma.

核心成分

Z-蒿本内酯 (Z-Ligustilide)，常伴随其异构体 E-蒿本内酯。

Z-Ligustilide, often accompanied by its isomer E-Ligustilide.

植物来源

伞形科植物当归 (Angelica sinensis(Oliv.) Diels) 的根
伞形科植物川芎 (Ligusticum chuanxiongHort.) 的根茎

Roots of Angelica sinensis (Oliv.) Diels (Apiaceae family)
Rhizomes of Ligusticum chuanxiong Hort. (Apiaceae family)

外观性状

淡黄色至无色油状液体或低熔点结晶（纯品）；或淡黄色至棕黄色粉末（环糊精包合物或提取物）。具有强烈的当归/川芎特有香气。

Pale yellow to colorless oily liquid or low-melting crystals (pure substance); or pale yellow to brownish-yellow powder (cyclodextrin inclusion complex or extract). Possesses a strong characteristic aroma of Danggui/Chuanxiong.

主要规格

高纯单体 (油状/结晶)：HPLC ≥98%, ≥99% (医药/科研级)
标准化提取物 (当归/川芎)：
- 蒿本内酯 0.5%, 1%, 2%, 5%, 10% (HPLC)
- 总苯酞 5%, 10%, 20% (HPLC)
环糊精包合物 (CD Complex)：蒿本内酯 5%, 10%, 20% (水溶性)

High Purity Monomer (Oil/Crystal): HPLC ≥98%, ≥99% (Pharma/Research Grade)
Standardized Extract (Angelica/Chuanxiong):
- Ligustilide 0.5%, 1%, 2%, 5%, 10% (HPLC)
- Total Phthalides 5%, 10%, 20% (HPLC)
Cyclodextrin Inclusion Complex (CD Complex): Ligustilide 5%, 10%, 20% (Water-soluble)

检测方法

HPLC, GC-MS

HPLC, GC-MS

CAS No.

Z-蒿本内酯: 4431-01-0
E-蒿本内酯: 72917-31-8

Z-Ligustilide: 4431-01-0
E-Ligustilide: 72917-31-8

分子式

C₁₂H₁₄O₂

C₁₂H₁₄O₂

分子量

190.24

190.24

药理功效

1. 活血行气与止痛 (Promotes Blood Circulation, Qi Movement & Alleviates Pain)：核心传统功效。舒张血管，改善微循环，抗血小板聚集，用于痛经、月经不调、跌打损伤。
2. 平滑肌解痉 (Smooth Muscle Spasmolysis)：松弛血管、气管、肠道平滑肌，缓解痉挛性疼痛。
3. 抗炎 (Anti-inflammatory)：抑制炎症介质释放和炎症通路。
4. 神经保护 (Neuroprotective)：可穿透血脑屏障，具有镇静、抗抑郁、抗惊厥作用，改善认知功能。
5. 抗氧化 (Antioxidant)：清除自由基。
6. 抗肿瘤 (Antitumor)：诱导肿瘤细胞凋亡。

1. Promotes Blood Circulation, Qi Movement & Alleviates Pain: Core traditional function. Dilates blood vessels, improves microcirculation, inhibits platelet aggregation. Used for dysmenorrhea, irregular menstruation, and traumatic injuries.
2. Smooth Muscle Spasmolysis: Relaxes vascular, tracheal, and intestinal smooth muscles, relieving spasmodic pain.
3. Anti-inflammatory: Inhibits release of inflammatory mediators and inflammatory pathways.
4. Neuroprotective: Can cross the blood-brain barrier, exerts sedative, antidepressant, and anticonvulsant effects, improves cognitive function.
5. Antioxidant: Scavenges free radicals.
6. Antitumor: Induces apoptosis of tumor cells.

应用领域

医药：妇科用药（痛经、月经不调、产后恢复）、心脑血管药物、止痛药、抗抑郁/安神药的原料或中间体。
保健品/功能性食品：女性健康产品（暖宫、调经）、改善血液循环产品、舒缓情绪/助眠产品。
化妆品：生发/防脱产品（改善头皮微循环）、舒缓抗敏产品（抗炎）、抗衰老产品（抗氧化、改善肤色暗沉）。
香料工业：天然定香剂，用于调配东方型、药草型香精。

Pharma: Raw material or intermediate for gynecological drugs (dysmenorrhea, irregular menstruation, postpartum recovery), cardio-cerebrovascular drugs, analgesics, and antidepressant/calming drugs.
Health Products/Functional Food: Women's health products (uterus warming, menstrual regulation), blood circulation improvers, mood-soothing/sleep aid products.
Cosmetics: Hair growth/anti-hair loss products (improves scalp microcirculation), soothing and anti-sensitive products (anti-inflammatory), anti-aging products (antioxidant, improves dull complexion).
Fragrance Industry: Natural fixative, used in compounding oriental and herbal fragrances.

包装储存

关键提示：本品易氧化、易挥发、对光和热敏感。
纯品/油状：深色安瓿瓶或充氮棕色玻璃瓶（1g, 5g, 10g）。
粉末/包合物：铝箔袋（1kg）或纸板桶（25kg）。
储存：密封，充氮或真空，避光，-20°C冷冻保存。保质期2年。

Critical Note: Prone to oxidation and volatilization, sensitive to light and heat.
Pure Substance/Oil: Dark ampoules or nitrogen-filled amber glass bottles (1g, 5g, 10g).
Powder/Complex: Aluminum foil bags (1kg) or cardboard drums (25kg).
Storage: Sealed, nitrogen-filled or vacuum, protected from light, store at -20°C (freezer). Shelf life 2 years.