上海创赛科技有限公司

两亲多烯抗生素，Amphotericin B是针对多种真菌病原体的多烯抗真菌 (fungal) 剂。 它与麦角甾醇不可逆地结合，导致膜完整性破坏并最终导致细胞死亡。

中文名称 ：Amphotericin B.

中文别名 ：两性霉素B;二性霉素B;两性霉素;两性霉素乙;可溶性两性霉素 B;两性霉属B;庐山霉素;多烯抗生素;两性多烯;可溶性两性霉素;两性酶素b;两性霉素B EP标准品;两性霉素B USP标准品;两性霉素B 标准品;两性霉素B,BR;两性霉素B-13C6;两性霉素B峰鉴别 EP标准品;两性霉素B口服粉;两性霉素B微生物鉴定 EP标准品;两性霉素B（冷藏运输）;芦山霉素;两性霉素 B 来源于链霉菌 属;两性霉素 B;异性霉素
英文名称 ：Amphotericin B
英文别名 ：Amphotericin B;33-[(3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid;ABELCET;AMBISOME;AMPHOTERCIN B;AMPHOTERICIN B SOLUBILIZED;AMPHOTERICIN B, SOLUBLE;AMPHOTERICIN B, STREPTOMYCES NODOSUS;AMPHOTERICIN B, STREPTOMYCES SPECIES;AMPHOZONE;FUNGIZONE;FUNGIZONE(R);Amphotericin B trihydrate;Abelecet;Amphocin;AMPHOTERICIN B, NON STERILE;fungilin;Halizon;LNS-AmB;ns718;Fungizone;33-[(3-Amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid;F;amphotericineb;amphotericinbstandardsolution;ampho-moronal;amphomoronal;33-((3-amino-3,6-dideoxy-beta-d-mannopyranosyl)oxy)-1,3,5,6,9,11,-xylicaci;14,39-dioxabicyclo(33.3.1)nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carbo
Cas No. ：1397-89-3
分子式 ：C47H73NO17
分子量 ：924.08
包装储存 

4°C, protect from light

产品详情 
两亲多烯抗生素，Amphotericin B是针对多种真菌病原体的多烯抗真菌 (fungal) 剂。 它与麦角甾醇不可逆地结合，导致膜完整性破坏并最终导致细胞死亡。

生物活性 
Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

性状 ：Solid
IC50 & Target[1][2] 
Fungal

体外研究(In Vitro) 
Amphotericin B administration is limited by infusion-related toxicity, including fever and chills, an effect postulated to result from proinflammatory cytokine production by innate immune cells. Amphotericin B induces signal transduction and inflammatory cytokine release from cells expressing TLR2 and CD14. Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase. Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na entry into the cells.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo) 
Amphotericin B results in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. Amphotericin B markedly reduces PrPSc levels in mice with transmissible subacute spongiform encephalopathies (TSSE). Amphotericin B exerts a direct effect on Plasmodium falciparum and influences eryptosis of infected erythrocytes, parasitemia and hostsurvival in murine malaria. Amphotericin B tends to delay the increase of parasitemia and significantly delays host death plasmodium berghei-infected mice.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件 
Room temperature or refrigerated transportation.

储存方式 
4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

结构分类 
Ketones, Aldehydes, Acids

来源 
Streptomyces?nodosus

参考文献 
[1]. Sau K, et al. The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. J Biol Chem. 2003 Sep 26;278(39):37561-8. Epub 2003 Jul 14.  [Information]
[2]. Barwicz J, et al. The effect of aggregation state of amphotericin-B on its interactions with cholesterol- or ergosterol-containing phosphatidylcholine monolayers. Chem Phys Lipids. 1997 Feb 28;85(2):145-55.  [Information]
[3]. Ramos H, et al. Amphotericin B kills unicellular leishmanias by forming aqueous pores permeable to small cations and anions. J Membr Biol. 1996 Jul;152(1):65-75.  [Information]
[4]. Demaimay R, et al. Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie. J Gen Virol. 1994 Sep;75 (Pt 9):2499-503.  [Information]
[5]. Adams ML, et al. Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced 体外研究 hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules. 2003 May-Jun;4(3):750-7.  [Information]

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