上海陌孚医药科技有限公司

中文名称 
2,5-二羟基苯甲酸.
中文别名 
2,5-二羟基苯甲酸;5-羟基水杨酸;龙胆酸;氢醌羧酸;2,5-二羟基苯甲酸(龙胆酸);2,5-二羥苯甲酸;龍膽酸;2,5-Dihydroxybenzoic Acid 2,5-二羟基苯甲酸;2.5-二羟基苯甲酸;美拉沙嗪杂质G(EP) 标准品;美沙拉嗪杂质G;2,5-二羟基苯甲酸 标准品;MS] 2,5-二羟基苯甲酸[ MALDI-TOF;MS基质];龙胆酸,2,5-二羟基苯甲酸,5-羟基水杨酸;龙胆酸,5-羟基水杨酸;龙胆酸,氢醌羧酸;2,5-二羟基苯甲酸，医药级,纯度:>99%
英文名称 
gentisate
英文别名 
2,5-Dihydroxybenzoic acid;Gentisic acid;Hydroquinonecarboxylic acid;2,5-Dhba;2,5-dihydroxy-benzoicaci;2,5-Dioxybenzoic acid;5-Hydroxysalicylic acid;5-hydroxy-salicylicaci;acido2,5-diidrossibenzoico;Benzoic acid, 2,5-dihydroxy-;2,5-Dihydroxybenzoic Acid (DHB);2.5-Dihydroxybenzoicacid;GENTISIC ACID(RG);2,5-DHBA,DHB,Gentisic acid;2,5-dihydroxybenzoate;2,5-dihydroxy-benzoic acid;2,5-dihydroxyphenylcarboxylic acid;Benzoic acid,2,5-dihydroxy;Gensigen;Gensigon;Gentisate;Hydroquinonecarboxylic acid;MS];DHB;DHBA;2,5-Dihydroxy benzoic acid;Gentisinic acid;Carboxyhydroquinone;Salicylic acid, 5-hydroxy-;Kyselina gentisinova;Gentisinate;Kyselina gentisinova [Czech];Acido gentisico [INN-Spanish];Kyselina 2,5-dihydroxybenzoova;Acidum gentisicum [INN-Latin];Acide gentisique [INN-French];Acido 2,5
Cas No. 
490-79-9
分子式 
C7H6O4
分子量 
154.12
包装储存 
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

生物活性 
2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.
性状 
Solid
IC50 & Target[1][2] 
Fibroblast growth factor
 
Human Endogenous Metabolite
 
体外研究(In Vitro) 
2,5-Dihydroxybenzoic acid (Gentisic acid) is a derivative of benzoic and a minor product of the metabolic break down of aspirin. 2,5-Dihydroxybenzoic acid is also a component of many traditional liquors and herbal remedies, is singled out as a powerful inhibitor of fibroblast growth factors. 2,5-Dihydroxybenzoic acid is used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it is shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo) 
It is verified from in vivo disease models that this group of inhibitors (e.g., 2,5-Dihydroxybenzoic acid) may be of interest to treat cancer and angiogenesis-dependent diseases.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件 
Room temperature or refrigerated transportation.
储存方式 
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
结构分类 
Phenols
Polyphenols
Ketones, Aldehydes, Acids
参考文献 
[1]. Levy G, et al. Salicylate accumulation kinetics in man. N Engl J Med. 1972 Aug 31;287(9):430-2.  [Information]
[2]. IS Fernández, et al. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. Journal of Biological Chemistry , 2010, 285(15):11714-29.  [Information]