上海创赛科技有限公司

Carglumic Acid (Ureidoglutaric acid) is an orphan drug used to treat hyperammonemia in patients with N-acetyl glutamate synthase absence. This rare hereditary disease results in elevated blood levels of ammonia, which can eventually cross the blood-brain barrier and lead to neurologic problems, coma, cerebral edema, and death. Carglumic acid was approved by the U.S. FDA on 18 March 2010.

中文名称 
N-Carbamyl-L-glutamic acid.
中文别名 
N-氨基甲酰-L-谷氨酸;氨甲酰谷氨酸;N-氨甲酰基谷氨酸;N-氨甲酰-L-谷氨酸;N-氨基甲酰谷氨酸;N-氨基甲酰基-L-谷氨酸;N-氨基甲酰-L-谷氨酸(N-氨甲酰-L-谷氨酸);N-氨基甲酰谷氨酸(NCG);N-氨甲酰谷氨酸;Carglumic酸;葡萄糖二酸鈣;卡哥鲁酸
英文名称 
(S)-2-Ureidopentanedioic acid
英文别名 
(S)-2-Ureidopentanedioic acid;N-CARBAMYL-L-GLUTAMIC ACID;carbamino-l-glutamicacid;carbamylglutamicacid;n-(aminocarbonyl)-l-glutamicaci;n-carbamylglutamate;ureidoglutaricacid;N-carbamyl-L-glutamic acid crystalline;(2S)-2-(aminocarbonylamino)pentanedioic acid;(2S)-2-(carbamoylamino)pentanedioic acid;NCG;Carglumic Acid
Cas No. 
1188-38-1
分子式 
C6N2O5H10
分子量 
190.15
包装储存 
Powder: -20°C for 3 years | In solvent: -80°C for 1 year

产品详情 
Carglumic Acid (Ureidoglutaric acid) 是一种 N-乙酰谷氨酸 (NAG) 的功能类似物和氨甲酰磷酸合成酶 1(CPS1)的活化剂，可用于与 N-乙酰谷氨酸合成酶 (NAGS) 缺陷相关的急性和慢性高氨血症的研究。
储存方式 
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
参考文献 
1. Carglumic acid. Prescrire Int. 2008 Apr;17(94):50-1.