钟为慧教授科研成果|告别盲目筛选！18种PNN配体，让不对称氢化少走弯路

发布人：北京百灵威科技有限公司

发布日期:2026/8/10 15:09:34

不对称氢化是构建手性醇、手性胺等药物及精细化学品关键中间体最高效、最原子经济的方法之一。配体的设计直接决定了催化体系的活性和对映选择性。

浙江工业大学钟为慧教授开发出一系列手性二茂铁骨架PNN三齿配体，涵盖f-Diaphos、咪唑/苯并咪唑PNN等经典配体系列，适用于Ir、Mn、Ru等多种过渡金属催化的不对称氢化、动态动力学拆分（DKR）及借氢反应，为您的手性合成提供“即用型”解决方案。

核心优势：

- 性能卓越，文献佐证：f-Diaphos/Ir体系在芳基烷基酮的不对称氢化中，对映选择性高达99.4% ee，转化数（TON）可达100,000[1,2] ；在非邻位取代2-吡啶基芳基酮氢化中同样表现优异[3]。

- 挑战底物，轻松应对：成功应用于α-氟/氯-β-酮酰胺/酯的动态动力学拆分（DKR）[1,4]，以及非邻位取代2-吡啶基芳基酮 [3]、2-咪唑基芳基/烷基酮等杂环酮底物的高选择性氢化。

- 金属兼容，体系丰富：除铱催化体系外，相关咪唑类PNN配体还可与锰配位，实现二苯甲酮、α,β-不饱和酮等底物的不对称氢化，对映选择性高达>99% ee [5]，拓展了廉价金属在不对称合成中的应用。

- 可放大，可负载：相关催化体系已实现克级规模放大，负载型f-Diaphos配体更可应用于连续流反应，在百克级规模下稳定运行，展现出工业化潜力 [2]。

百灵威稳定供应一系列手性二茂铁骨架PNN三齿配体及相关配套产品，助力不对称合成。

产品清单

f-Diaphos系列配体

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品名CAS货号

(1R)-1-(Diphenylphosphino)-2-[(1R)-1-[[[[(1R,2R)-2-[[[[(2,4,6-trimethylphenyl)sulfonyl]amino]cyclohexyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1R)-1-(二苯基膦基)-2-[(1R)-1-[[[[(1R,2R)-2-[[[[(2,4,6-三甲基苯基)磺酰基]氨基]环己基]氨基]乙基]二茂铁

2241798-02-5

9743081

(1R)-1-(Diphenylphosphino)-2-[(1R)-1-[[[[(1R,2R)-2-[[[[(4-methylphenyl)sulfonyl]amino]cyclohexyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1R)-1-(二苯基膦基)-2-[(1R)-1-[[[[(1R,2R)-2-[[[[(4-甲基苯基)磺酰基]氨基]环己基]氨基]乙基]二茂铁

2197989-00-5

9743082

(1R)-1-[Bis[[3,5-bis(1,1-dimethylethyl)phenyl]phosphino]-2-[(1R)-1-[[[[(1R,2R)-2-[[[[(4-methylphenyl)sulfonyl]amino]cyclohexyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1R)-1-[双[[3,5-双(1,1-二甲基乙基)苯基]膦基]-2-[(1R)-1-[[[[(1R,2R)-2-[[[[(4-甲基苯基)磺酰基]氨基]环己基]氨基]乙基]二茂铁

2241798-10-5

9743083

(1R)-1-[Bis(3,5-dimethylphenyl)phosphino]-2-[(1R)-1-[[[[(1R,2R)-2-[[[[(2,4,6-trimethylphenyl)sulfonyl]amino]cyclohexyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1R)-1-[双(3,5-二甲基苯基)膦基]-2-[(1R)-1-[[[[(1R,2R)-2-[[[[(2,4,6-三甲基苯基)磺酰基]氨基]环己基]氨基]乙基]二茂铁

2241798-08-1

9743095

(1S)-1-(Diphenylphosphino)-2-[(1S)-1-[[[[(1S,2S)-2-[[[[(4-methylphenyl)sulfonyl]amino]cyclohexyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1S)-1-(二苯基膦基)-2-[(1S)-1-[[[[(1S,2S)-2-[[[[(4-甲基苯基)磺酰基]氨基]环己基]氨基]乙基]二茂铁

2241798-15-0

9743096

(1S)-1-(Diphenylphosphino)-2-[(1S)-1-[[[[(1S,2S)-2-[[[[(2,4,6-trimethylphenyl)sulfonyl]amino]cyclohexyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1S)-1-(二苯基膦基)-2-[(1S)-1-[[[[(1S,2S)-2-[[[[(2,4,6-三甲基苯基)磺酰基]氨基]环己基]氨基]乙基]二茂铁

2368926-14-9

9743097

(1S)-1-[Bis[[3,5-bis(1,1-dimethylethyl)phenyl]phosphino]-2-[(1S)-1-[[[[(1S,2S)-2-[[[[(4-methylphenyl)sulfonyl]amino]cyclohexyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1S)-1-[双[[3,5-双(1,1-二甲基乙基)苯基]膦基]-2-[(1S,1S,2S)-2-[[[[(4-甲基苯基)磺酰基]氨基]环己基]氨基]乙基]二茂铁

2368926-18-3

9743098

咪唑/苯并咪唑系列配体

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品名CAS货号

(1R)-1-(Diphenylphosphino)-2-[(1R)-1-[[[[(1-methyl-1H-benzimidazol-2-yl)methyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1R)-1-(二苯基膦基)-2-[(1R)-1-[[[[(1-甲基-1H-苯并咪唑-2-基)甲基]氨基]乙基]二茂铁

2375958-02-2

9743099

(1S)-1-(Diphenylphosphino)-2-[(1S)-1-[[[[(1-methyl-1H-benzimidazol-2-yl)methyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1S)-1-(二苯基膦基)-2-[(1S)-1-[[[[(1-甲基-1H-苯并咪唑-2-基)甲基]氨基]乙基]二茂铁

2409181-81-1

9743100

(1S)-1-(Diphenylphosphino)-2-[(1S)-1-[[[[[[1-(phenylmethyl)-1H-benzimidazol-2-yl]methyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1S)-1-(二苯基膦基)-2-[(1S)-1-[[[[[[1-(苯基甲基)-1H-苯并咪唑-2-基]甲基]氨基]乙基]二茂铁

2375957-97-2

9743101

(2S)-1-[(1S)-1-[[(E)-[[[[1-[[2,6-Bis(1-methylethyl)phenyl]-1H-benzimidazol-2-yl]methylene]amino]ethyl]-2-(diphenylphosphino)ferrocene, 98%, ee≥99%
(2S)-1-[(1S)-1-[[(E)-[[[[1-[[2,6-双(1-甲基乙基)苯基]-1H-苯并咪唑-2-基]亚甲基]氨基]乙基]-2-(二苯基膦基)二茂铁

2346611-36-5

9743102

(2R)-1-[(1R)-1-[[(E)-[[[[1-[[2,6-Bis(1-methylethyl)phenyl]-1H-benzimidazol-2-yl]methylene]amino]ethyl]-2-(diphenylphosphino)ferrocene, 98%, ee≥99%
(2R)-1-[(1R)-1-[[(E)-[[[[1-[[2,6-双(1-甲基乙基)苯基]-1H-苯并咪唑-2-基]亚甲基]氨基]乙基]-2-(二苯基膦基)二茂铁

2346611-43-4

9743103

(1S)-1-[Bis(3,5-dimethylphenyl)phosphino]-2-[(1S)-1-[[[[[[1-(phenylmethyl)-1H-benzimidazol-2-yl]methyl]amino]ethyl]ferrocene, 98%, ee≥99%
(1S)-1-[双(3,5-二甲基苯基)膦基]-2-[(1S)-1-[[[[1-(苯基甲基)-1H-苯并咪唑-2-基]甲基]氨基]乙基]二茂铁

2375958-00-0

9743104

其他二茂铁配体

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品名CAS货号

(1S)-1-(Diphenylphosphino)-2-[(1S)-1-[[methyl[[(11aR)-10,11,12,13-tetrahydrodiindeno[[7,1-de:1′,7′-fg][1,3,2]dioxaphosphocin-5-yl]amino]ethyl]ferrocene, 98%, ee≥99%
(1S)-1-(二苯基膦基)-2-[(1S”-1-[[甲基[[(11aR)-10,11,12,13-四氢二茚并[[7,1-de:1′,7′-fg][1,3,2]二氧膦-5-基]氨基]乙基]二茂铁

2775428-44-7

9743105

(2R)-1-[(1R)-1-[[[[[[(2,4,6-trimethyl)benzoyl]amino]thioxomethyl]amino]ethyl]-1′,2-bis(diphenylphosphino)ferrocene, 98%, ee≥99%
(2R)-1-[(1R)-1-[[[[[[(2,4,6-三甲基)苯甲酰基]氨基]硫氧甲基]氨基]乙基]-1’,2-双(二苯基膦基)二茂铁

2907054-15-1

9743106

(2R)-1-[(1R)-1-[[[[[[(3,5-dimethyl)benzoyl] amino]thioxomethyl] methylamino]ethyl]-1′,2-bis(diphenylphosphino)ferrocene, 98%, ee≥99%
(2R)-1-[(1R)-1-[[[[[[(3,5-二甲基)苯甲酰基]氨基]硫氧甲基]甲基氨基]乙基]-1′,2-双(二苯基膦基)二茂铁

2907054-07-1

9743110

(2R)-1-[(1R)-1-[[[[[[(3,5-di-tert-butyl)benzoyl] amino]thioxomethyl] methylamino]ethyl]-1′,2-bis(diphenylphosphino)ferrocene, 98%, ee≥99%
(2R)-1-[(1R)-1-[[[[[[(3,5-二叔丁基)苯甲酰基]氨基]硫氧甲基]甲基氨基]乙基]-1′,2-双(二苯基膦基)二茂铁

2907054-05-9

9743108

(2R)-1-[(1R)-1-[[[[[[(2,4,6-trimethyl)benzoyl]amino]thioxomethyl] methylamino]ethyl]-1′,2-bis(di(3,5-di-methyl)phenylphosphino)ferrocene, 98%, ee≥99%
(2R)-1-[(1R)-1-[[[[(2,4,6-三甲基)苯甲酰基]氨基]硫氧甲基]甲基氨基]乙基]-1′,2-双(二(3,5-二甲基)苯基膦基)二茂铁

2907054-17-3

9743109

金属前体

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品名CAS货号

Chloro(1,5-cyclooctadiene)iridium(I) dimer, 98%
1,5-环辛二烯氯化铱(I)二聚体

12112-67-3

192969

Manganese pentacarbonyl bromide, 97%
五羰基溴化锰

14516-54-2

139902

通用溶剂

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品名CAS货号

Ethanol, 99.5%, SuperDry, with molecular sieves, Water≤50 ppm, J&KSeal
乙醇

64-17-5

922424促
危化品

1,4-Dioxane, 99.5%, SuperDry, with molecular sieves, stabilized with BHT, J&Kseal, water≤50 ppm
1,4-二氧六环

123-91-1

972869促
危化品

Ethyl acetate, 99.9%, SuperDry, with molecular sieves, Water≤50 ppm, J&KSeal
乙酸乙酯

141-78-6

920352促
危化品

Isopropanol, 99.5%, SuperDry, with molecular sieves, Water≤50 ppm, J&KSeal
异丙醇

67-63-0

919270促
危化品

耗材

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品名CAS货号

Quantitative spotting capillary tubes, 1 μl, capacity error ±0.05 μl
定量点样毛细管

9219772

HPTLC silica gel plate (NaAc) (fluorescent indicator: no), 2% NaAc, 200*100 mm, layer thickness: 0.2-0.25 mm, particle size: 5-20 μm
高效薄层层析硅胶板(乙酸钠)(不含荧光)

2750251

Transfer pipets, 3 ml, 160 mm, PE, capacity 7.5 ml, unsterile
吸管

989082

Magnetic stir bar, PTFE-coated, egg-shaped, A200(8-9mm*20mm), 5 pcs/pack
聚四氟乙烯磁力搅拌子,椭圆型

978702

参考文献

Iridium-Catalyzed Asymmetric Hydrogenation of Aryl α-Chloro-β-Keto Esters and Aryl Alkyl Ketones, Org. Lett., 2026, 28(14), 4531–4536.
Development of Heterogeneous P-N-N Tridentate Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones in Batch and Flow, Green Chem., 2025, 27, 3684–3692.
Highly Enantioselective Hydrogenation of Non-ortho-Substituted 2-Pyridyl Aryl Ketones via Iridium-f-Diaphos Catalysis, Org. Lett., 2019, 21(14), 5392–5396.
Asymmetric Hydrogenation of α-F-β-ketone Amides (Esters) via Ir/f-Diaphos Catalyzed Dynamic Kinetic Resolution, Org. Chem. Front., 2024, 11(8), 2201–2207.
Highly Enantioselective Synthesis of Chiral Benzhydrols via Manganese Catalyzed Asymmetric Hydrogenation of Unsymmetrical Benzophenones using an Imidazole-Based Chiral PNN Tridentate Ligand, Org. Lett., 2019, 21(11), 3937–3941.