文章标题：A chlorophyll a oxygenase 1 gene ZmCAO1 contributes to grain yield and waterlogging tolerance in maize
影响因子：6.992
期刊：JOURNAL OF EXPERIMENTAL BOTANY
作者列表：Li Qin, Zhou Shuangzhen, Liu Wenyu, Zhai Zhensheng, Pan Yitian, Liu Changchang, Chern Mawsheng, Wang Hongwei, Huang Min, Zhang Zuxin, Tang Jihua, Du Hewei
发表时间：2021-2-11
DOI:10.1093/jxb/erab059
主要研究成果：Introduction
During the combined treatment of tumors, the non-interfering transportation of drugs with different solubilities and the controllable sequential release are the main challenges. Here, we reported a double-chamber "Dandelion" -like sequential drug delivery system to realize the sequential release of different drugs for treating malignant tumors synergistically.
Methods
After synthesizing mesoporous silica nanoparticles (MSN) by template method, a hydrophilic chemotherapy drug doxorubicin (DOX) was loaded into the channels of mesoporous silica (MSN) and locked with polydopamine (PDA) coating. Next, β-cyclodextrin (β-CDs) was decorated on PDA by Michael addition reaction, and the hydrophobic photosensitizer chlorin e6 (Ce6) was encapsulated into the hydrophobic chambers of β-CDs. Finally, AS1411 was modified on the surface of PDA and obtained DOX@MSN@PDA-β-CD/Ce6-AS1411 nanoparticles (DMPCCA) through which orthogonal loading and effective controlled release of different drugs were realized.
文献网址：https://europepmc.org/article/pmc/pmc9444041?javascript_support=no
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