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凯立德生物产品线之——维生素D衍生物系列(Vitamin D Related)!

发布人:凯立德生物医药技术(上海)有限公司

发布日期:2020/1/3 16:39:48

凯立德生物产品线之——维生素D衍生物系列(Vitamin D Related)!Vitamin D Related通路中的靶点 VD/VDR Vitamin D/Vitamin D receptor

维生素D有多种食物来源,如鱼,鸡蛋,强化牛奶,鱼肝油等。太阳光有助于维生素D的生成,每天晒10分钟太阳就可以补充日常所需维生素D。维生素D包含多种形式,人体内重要的两种形式为:麦角钙化醇(维生素D2)和胆钙化醇(维生素D3) 。维生素D2由植物合成。维生素D3是人体暴露在太阳光下,阳光中的紫外线促进皮肤生成。食品中可添加维生素D2或D3 。维生素D的主要生物学功能是维持血液中钙和磷的正常水平。维生素D促进钙吸收,有助于形成和维持强健的骨骼。维生素D可以单独使用或是和钙组合使用,用来增加骨密度和减少骨折的发生。最近,研究还表明,维生素D可以降低骨质疏松症、高血压、癌症和一些自身免疫性疾病的发病率。维生素D可以通过活化有免疫调节功能的维生素D受体来调节胰腺中胰岛素的分泌。维生素D受体的基因多态性可能影响维生素D的功能以及免疫应答反应,维D受体可能是易感性1型糖尿病(T1DM)的一个影响因素。

佝偻病和骨软化症是典型的维生素D缺乏病。在儿童中,维生素D缺乏引起佝偻病,这会导致骨骼畸形。在成人中,维生素D缺乏可导致骨软化症,导致肌肉无力、骨骼脆弱。维生素D缺乏的高危人群包括:老年人、肥胖者、纯母乳喂养的婴儿、长期不见阳光的人群。另外,吸收障碍综合征患者(如囊性纤维病)和炎性肠病患者(如克罗恩氏病)都是维生素D缺乏的高危人群。

Product Name   
CAS No. 
M. F.
M. W.
1alpha,25-Dihydroxycholecalciferol; (5Z,7E)-(1S,3R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol; Calcitriol; 1,25-Dihydroxyvitamin D3;(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol; 1α,25-dihydroxy Vitamin D3; 9,10-secocholesta-5Z,7E,10(19)-triene-1α,3β,25-triol
32222-06-3
C27H44O3
416.64
(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7α-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol; 1α, 25-Dihydroxyvitamin D2;Ercalcitriol; 1alpha,25-Dihydroxyvitamin D2;1alpha,25-Dihydroxycalciferol; 1,25-dihydroxy Vitamin D2; Ro 17-6218
60133-18-8
C28H44O3
428.65
(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7α-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; 4-methylene-5Z-[2E-[(1R,3aS)-octahydro-7aR-methyl-1R-[1R,4,5-trimethyl-2E-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3S-cyclohexanediol; Doxercalciferol;1-hydroxy Vitamin D2; 1.alpha.-Hydroxyvitamin D2; 1-Hydroxyergocalciferol;TSA 840;(1S,3R,5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol;1-Hydroxyvitamin D2; 1α-Hydroxyergocalciferol; 1α-Hydroxyvitamin D2
54573-75-0
C28H44O2
412.65
(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol; Alfacalcidol; 1-Hydroxycholecalciferol; 5-[2E-[(3aS)-1R-[1R,5-dimethylhexyl]octahydro-7aR-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1R,3R-cyclohexanediol; 1-hydroxy Vitamin D3;1.alpha.-Hydroxyvitamin D3; 1-alpha-Hydroxycholecalciferol; (1alpha,3beta,5Z,7E)-Secocholesta-5,7,10(19)-triene-1,3-diol
41294-56-8 
 C27H44O2
400.64
(1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol;Paricalcitol;(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol;1α,25-Dihydroxy-19-nor-vitamin D2;19-nor-1,25-Dihydroxyvitamin D2
131918-61-1
C27H44O3 
416.64
2-(3-Hydroxypropoxy)-1,25-dihydroxyvitamin D3;ED-71;Eldecalcitol;2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3
104121-92-8 
C30H50O5
490.72
4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexenyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-cyclohexanol; 25-Hydroxyvitamin D2;Ercalcidiol; 25-Hydroxycalciferol; 25-Hydroxyergocalciferol;25-hydroxy Vitamin D2;3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3,25-diol
21343-40-8
C28H44O2 
412.65
(1R,3S,5Z)-5-((2E)-((1R,3aS,7aR)-1-((1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol; Seocalcitol; EB 1089;  EB-1089;  EB1089
134404-52-7
C30H46O3
454.68
(1α,3β,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol;Tacalcitol;4-methylene-5Z-[2E-[(3aS)-octahydro-1R-[4R-hydroxy-1R,5-dimethylhexyl]-7aR-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol; 1,24-dihydroxy Vitamin D3; 1α,24(R)-Dihydroxycholecalciferol; PRI 2191; 1,24(R)-Dihydroxyvitamin D3;  1.alpha.,24R-Dihydroxyvitamin D3
57333-96-7
C27H44O3 
416.64
(1S,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(E,2S)-5-Cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol; (1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol; Calcipotriol;MC 903; Calcipotriene
112965-21-6
C27H40O3
412.62
(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate;Calcipotriol Monohydrate
147657-22-5 
C27H42O4 
430.62
(εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol; Calcifediol; 25-Hydroxyvitamin D3; Calcidiol; 25-hydroxy Vitamin D3;4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-(εR,1R,3aS,4E,7aR)-1H-indene-1-pentanol;25-hydroxy Cholecalciferol;RO 8-8892; Rovimix Hy-D; U 32070E
19356-17-3
C27H44O2
400.64
(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3b,25-diol monohydrate; 25-Hydroxycholecalciferol monohydrate; 25-OHD3; 25-Hydroxyvitamin D3 monohydrate; 25-hydroxy Vitamin D3 monohydrate;Calcifediol Monohydrate
63283-36-3 
C27H46O3
418.65
(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol;Maxacalcitol;22-Oxacalcitriol;  (+)-(5Z,7E)-(1S,3R,20S)-20-(3-Hydroxy-3-methylbutyloxy)-9,10-secopregna-5,7,10(19)-triene-1,3-diol; 4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol
103909-75-7  
C26H42O4
418.61
Vitamin D2; 9,10-Secoergosta-5,7,10,22-tetraen-3-ol; Calciferol; Ergocalciferol; Oleovitamin D2; Ercalciol
50-14-6 
C28H44O 
396.65
9,10-Secocholesta-5,7,10(19)-trien-3β-ol; Cholecalciferol;Vitamin D3;9,10-Secocholesta-5,7,10(19)-trien-3beta-ol; Colecalciferol; (5Z,7E,3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol; 3Z-[2E-[(1R,3aS,7aR)-1S-[1R,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol; NSC 375571
67-97-0
C27H44O 
384.64
22,23-Dihydroercalciol; 22,23-Dihydroergocalciferol; 22,23-Dihydrovitamin D2; 24S-Methylcalciol; (1S,3Z)-4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,4S)-1,4,5-Trimethylhexyl]-4H-inden-4-ylidene]ethylidene]cyclohexanol; Vitamin D4
511-28-4
C28H46O
398.66
(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; Falecalcitriol
83805-11-2
C27H38F6O3
524.58

 

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