上海陌孚医药科技有限公司

4-Deoxy-11,12-didehydroandrographolide 是 Andrographolide 的类似物。14-Deoxy-11,12-didehydroandrographolide 抑制 NF-κB 活化。

中文名称 
14-deoxy-11,12-didehydro Andrographolide
中文别名 
穿心莲内酯;14-去氧-11,12-二去氢穿心莲内酯;14-脱氧-11,12-二脱氢穿心莲内酯;14-脱氧11,14-二脱氢穿心莲内酯;脱氧-11,12-二脱氢穿心莲内酯,14-(P);穿心莲内酯 穿心莲乙素;穿心莲内酯标准品对照品;脱水穿心莲内酯;雄茸交酯
英文名称 
14-deoxy-11,12-didehydro Andrographolide
英文别名 
2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]-;14-Deoxy-11,12-didehydroandrographolide;2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl];AP-10;DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE, 14-(P);DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE, 14-(SH);14-dehydro Andrographolide;4-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one;AP10;3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone;ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide;14-Deoxy-11,14-didehydroandrographolide;[ "3", "19-Dihydroxylabda-8(17)", "11", "13-trien-16", "15-olide" ];4-[2-[(4As,5R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H;5S0X4YZJ0E;3-{(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethenyl}furan-2(5H)-one;MLS001215174;MEGxp0_000982;HMS2881G03;BBL010995;STK802121;NCGC0016364
Cas No. 
42895-58-9
分子式 
C20H28O4
分子量 
332.43

生物活性 
14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation.
性状 
Solid
IC50 & Target[1][2] 
NF-κB

体外研究(In Vitro) 
14-deoxy-11,12-didehydroandrographolide, a naturally occurring noncytotoxic analogue of Andrographolide, effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid, IL-4, IL-5, IL-13, and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness (AHR) in a mouse asthma model, probably via inhibition of NF-κB activity.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo) 
14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件 
Room temperature or refrigerated transportation.

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