普健生物（武汉）科技有限公司

标题：Anti-Human TSHR/LGR3 Antibody (M22)抗体,AntibodySystem Laboratories

链接：https://www.antibodysystem.com/product/7263.html

名称：Anti-Human TSHR/LGR3 Antibody (M22)抗体

别名：Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3

货号：FHD18110

宿主：Human

适用物种：Human

存储缓冲区：0.01M PBS, pH 7.4.

形式：Liquid

纯度：>95%

克隆：Monoclonal

同型：IgG1

应用：FCM

内毒素水平：Please contact with the lab for this information.

UniProt：P16473

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

产品购买联系方式：027-65279366 /18162686757

邮箱：biolab-reagents@atagenix.com

QQ：2663991332

参考文献：

A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves' orbitopathy. PMID: 36742308

Mechanisms of Action of TSHR Autoantibodies. PMID: 26361260

Modulation of TSHR signaling by posttranslational modifications. PMID: 17524661

Central Tolerance Mechanisms to TSHR in Graves' Disease: Contributions to Understand the Genetic Association. PMID: 30396220

TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease. PMID: 37690235

Controversial constitutive TSHR activity: patients, physiology, and in vitro characterization. PMID: 24845969

Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene. PMID: 26361261

Presence of TSHR in NK Cells and Action of TSH on NK Cells. PMID: 34392245

Signaling Dynamics of TSHR-Specific CAR-T Cells Revealed by FRET-Based Biosensors. PMID: 35252208

Variant of TSHR is Not a Frequent Cause of Congenital Hypothyroidism in Chinese Han Patients. PMID: 34377013

Association between TSHR gene methylation and papillary thyroid cancer: a meta-analysis. PMID: 32279226

LGR4: A New Receptor Member in Endocrine and Metabolic Diseases. PMID: 36791020

The biology and evolution of the Dilp8-Lgr3 pathway: A relaxin-like pathway coupling tissue growth and developmental timing control. PMID: 29715504

Sex-specific regulation of Lgr3 in Drosophila neurons. PMID: 26884206

Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain. PMID: 33558728

Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability. PMID: 26441350

Mating activates neuroendocrine pathways signaling hunger in Drosophila females. PMID: 37184218

[Some insulins to orchestrate growth]. PMID: 28990566

Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. PMID: 26510564

The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction. PMID: 34099654

A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3. PMID: 26429885

Systemic signalling and local effectors in developmental stability, body symmetry, and size. PMID: 31225459

Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland. PMID: 27558136

Drosophila Insulin-Like Peptide 8 (DILP8) in Ovarian Follicle Cells Regulates Ovulation and Metabolism. PMID: 32849266

Ecdysone regulates the Drosophila imaginal disc epithelial barrier, determining the length of regeneration checkpoint delay. PMID: 33658221

Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides. PMID: 26472340

Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc. PMID: 37817293

Hormone- and antibody-mediated activation of the thyrotropin receptor. PMID: 35940204

Supplemented phase diagrams for vitrification CPA cocktails: DP6, VS55 and M22. PMID: 35276219

Human disease isolates of serotype m4 and m22 group a streptococcus lack genes required for hyaluronic acid capsule biosynthesis. PMID: 23131832

Sweet Dreams for Better Metabolic Health. PMID: 37265231

A New Method of Myostatin Inhibition in Mice via Oral Administration of Lactobacillus casei Expressing Modified Myostatin Protein, BLS-M22. PMID: 36012334

The M22 antibody identifies highly activated reactive astrocytes responding to central nervous system disease. PMID: 8834543

Unexpected Crosslinking Effects of a Human Thyroid Stimulating Monoclonal Autoantibody, M22, with IGF1 on Adipogenesis in 3T3L-1 Cells. PMID: 36674625

Biochemical and biological activity of arginine deiminase from Streptococcus pyogenes M22. PMID: 26695833

Comparison of Intense Pulsed Light Therapy on Patients with Meibomian Gland Dysfunction Using AQUA CEL and M22 Devices. PMID: 35893356

Analysis of Treatment Efficacy of Intense Pulsed Light (M22) for Meibomian Gland Dysfunction with Demodex Mites. PMID: 38164126

Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity. PMID: 35142659

M22 based (manual) ELISA for TSH-receptor antibody (TRAb) measurement is more sensitive than 2nd generation TRAb assays. PMID: 19361467

Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein-protein interactions. PMID: 19221175

Cryoprotectant toxicity in Caenorhabditis elegans. PMID: 30527584

A stimulatory thyrotropin receptor antibody (M22) and thyrotropin increase interleukin-6 expression and secretion in Graves' orbital preadipocyte fibroblasts. PMID: 20017620

Thyrotropin Receptor Antagonism by a Novel Small Molecule: Preclinical In Vitro Observations. PMID: 37016815

Effects of a thyroid-stimulating human monoclonal autoantibody (M22) on functional activity of LH and FSH receptors. PMID: 17123334

TSH receptor antibodies. PMID: 17900238