Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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Mestinon(101-26-8)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
Mestinon
Synonyms
(1-Methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate bromide
2-((1-Methylethyl)thio)ethanol
2-Propan-2-ylsulfanylethanol
3-(Dimethylcarbamyloxy)-1-methylpyridinium bromide
3-Hydroxy-1-methylpyridinium bromide dimethylcarbamate
Kalymin
Mestinon
CAS
101-26-8
CAS
40811-49-2
Formula
C5H12OS
Formula
C9H13BrN2O2
Molecular Weight
120.22
Molecular Weight
261.12
EINECS
202-929-9
EINECS
255-090-6
RTECS
UU5270000
RTECS Class
Drug; Reproductive Effector; Human Data
Merck
12,8161
Beilstein/Gmelin
1697233
Beilstein/Gmelin
3764573
Beilstein Reference
4-01-00-02432
Beilstein Reference
4-21-00-00415

Physical and Chemical Properties

Appearance
White or practically white, crystalline powder. Agreeable odor.
Solubility in water
Freely soluble
Melting Point
154 - 155
Boiling Point
88 (25 torr)
Density
0.9613 g/cm3 (20 C)
Usage
Medication.
Refractive Index
1.48 (20 C)

First Aid Measures

Ingestion
Never induce vomiting unless directed by medical personnel. Never give anything by mouth to an unconscious person. Obtain medical assistance.
Ingestion
Seek medical assistance.
Inhalation
TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
Inhalation
Remove to fresh air. Give CPR, oxygen if needed.
Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
Skin
Immediately wash with soap and water.
Skin
Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
Eyes
Flush with water for 15 minutes.
Eyes
Immediately flush with running water for at least 20 minutes.
Eyes
See Inhalation.

Handling and Storage

Storage
Keep in a cool, dry location in a tightly closed container when not in use.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Ingestion
See Inhalation.
Inhalation
Excess secretions in the tracheal tree, bronchospasm, and pulmonary edema may occur.
Skin
Dermatitis, urticaria and reversible alopecia have been reported.
Eyes
Constriction of the pupil, blurred vision, and excessive secretions in the nose and throat may be present.
Ingestion
Cramping, abdominal pain, hyperperistalsis, vomiting, and diarrhea have been described.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
EC Risk Phrase
R 20/21/22
EC Safety Phrase
S 23 36/37
UN (DOT)
2810

Exposure Controls/Personal Protection

Personal Protection
Plastic/rubber gloves, safety goggles and disposable coveralls.
Personal Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Respirators
Half face, negative pressure air purifying, dust/mist/fume efficiency filter respirator. Supplied air, full facepiece respirator.
Exposure Effects
Abnormally low blood pressure may occur from peripheral actions. However, elevated blood pressure may also be seen secondary to the anxiety resulting from the effects on other organ systems. Likewise, bradyarrhythmias are common from the antimyasthenics, but rapid heart rate may occur secondary to the anxiety resulting from the effects on other organ systems. Respiratory rate may be increased in patients with airway compromise. seizures and coma have been described; profound weakness and muscle fasciculations may also occur. In less severe cases, headache, dizziness, and dysarthria may occur. Parkinsonian-like symptoms have been reported during therapeutic use of pyridostigmine.

Fire Fighting Measures

Fire Fighting
Extinguish with water, carbon dioxide, dry chemical or foam. Wear NIOSH/MSHA approved, positive pressure SCBA and full protective turn out gear.
Fire Fighting
Small Fires: Dry chemical, carbon dioxide or water spray. Large Fires: Dry chemical, carbon dioxide, alcohol-resistant foam or water spray.
Fire Potential
Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks
ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Small spills/leaks
Scoop/shovel material into a suitably labeled drum. Secure drum cover and move container to a safe holding area.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures in in a tightly sealed container.
Decomposition
Oxides of carbon, oxides of nitrogen, hydrogen bromide and brominated compounds.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number
2810
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