Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid > 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid(81-25-4)

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid(81-25-4)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid
Synonyms
(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
17b-[1-Methyl-3-carboxypropyl]etiocholane-3a,7a,12a-triol
5b-Cholanic acid-3a,7a,12a-triol
5b-Cholic acid
Cholan-24-oic acid, 3,7,12-trihydroxy-, (3a,5b,7a,12a)-
CAS
81-25-4
Formula
C24H40O5
Molecular Weight
408.57
EINECS
201-337-8
RTECS
FZ9350000
RTECS Class
Mutagen
Merck
13,2223
Beilstein/Gmelin
2822009
Beilstein Reference
4-10-00-02072

Physical and Chemical Properties

Appearance
White.
Solubility in water
Insoluble
Melting Point
199
Boiling Point
545
pKa/pKb
4.76 (pKa)
Partition Coefficient
3.04
Usage
One of two major bile acids produced by the liver where it is synthesized from cholesterol.

First Aid Measures

Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage
Store in a cool, dry place. Keep container closed when not in use.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion
The toxicological properties of this substance have not been fully investigated.
Inhalation
The toxicological properties of this substance have not been fully investigated.
Skin
No information regarding skin irritation and other potential effects was found.
Eyes
May cause eye irritation. No information regarding eye irritation and other potential effects was found.
EC Safety Phrase
S 22 24/25

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures

Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.

Stability and Reactivity

Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizers.
Decomposition
Irritating and toxic fumes and gases.
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