Supplier Product Identification Physical and Chemical Properties Handling and Storage Stability and Reactivity
Home > 3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide > 3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide(465-21-4)

3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide(465-21-4)

Supplier Product Identification Physical and Chemical Properties Handling and Storage Stability and Reactivity

Product Identification

Product Name
3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide
Synonyms
3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide
5-(3,14-Dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pyran-2-one
Bufa-20,22-dienolide, 3,14-dihydroxy-, (3-beta,5-beta)-
Bufalin
CAS
465-21-4
Formula
C24H34O4
Molecular Weight
386.53
RTECS
EI2962500
Merck
12,1493
Beilstein/Gmelin
5141601

Physical and Chemical Properties

Appearance
White solid.
Solubility in water
Insoluble
Melting Point
242 - 243
Vapor Pressure
1.1E-14 (25 C)
Density
1.226 g/cm3 (20 C)
pKa/pKb
14.74
Partition Coefficient
3.42
Usage
A cardiotonic steroid isolated from bufo species toads that potently inhibits ouabain-sensitive na+,k+-atpase activity. Induces apoptosis in various human cell lines such as leukemia hl60 and u937 cells by altering the expression of apoptosis-related genes.

Handling and Storage

Storage
Store at -20 C, protect from light.

Stability and Reactivity

Incompatibilities
Air sensitive.
Stability
Stable for a year if stored as directed.
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