Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine > 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine(5786-21-0)

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine(5786-21-0)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Synonyms
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Azaleptine
Clorazil
Clozaril
Iprox
Leponex
CAS
5786-21-0
Formula
C18H19ClN4
Molecular Weight
326.83
EINECS
227-313-7
RTECS
HP1750000
RTECS Class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,2484
Beilstein/Gmelin
764984
Beilstein Reference
5-25-11-00364

Physical and Chemical Properties

Appearance
Yellow crystals from acetone-petroleum ether.
Solubility in water
Insoluble
Melting Point
182
Boiling Point
489
Vapor Pressure
1E-9 (25 C)
pKa/pKb
7.67 (pKb)
Heat Of Vaporization
75.5 kJ/mol
Usage
Atypical antipsychotic compound. Selective antagonist for d4-dopamine receptor. Antagonist at 5-ht2a, 5-ht2c, 5-ht3, 5-ht6, and 5-ht7serotonin receptors.

First Aid Measures

Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage
Keep tightly closed.

Hazards Identification

Inhalation
Material is irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
Skin
Causes skin irritation. May be harmful if absorbed through the skin.
Eyes
Causes eye irritation.
Ingestion
Harmful if swallowed.
Hazards
Emits toxic fumes under fire conditions.
EC Risk Phrase
22 36/37/38
EC Safety Phrase
26

Exposure Controls/Personal Protection

Personal Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Exposure Effects
Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.

Fire Fighting Measures

Flash Point
250
Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities
Oxidizing agents.
Stability
Stable at normal temperatures and pressures.
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