Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Terfenadine(50679-08-8)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Terfenadine
Synonyms
1-(4-tert-Butylphenyl)-4-(4-(alpha-Hydroxybenzhydryl)piperidino)butan-1-ol
1-(p-tert-Butylphenyl)-4-(4'-(alpha-hydroxydiphenylmethyl)-1'-piperidyl)-butanol
Aldaban
Allerplus
CAS
50679-08-8
Formula
C32H41NO2
Molecular Weight
471.68
EINECS
256-710-8
RTECS
TM4969000
RTECS Class
Drug; Reproductive Effector; Human Data
Merck
12,9307
Beilstein/Gmelin
5857899

Physical and Chemical Properties

Appearance
White to off-white crystalline powder.
Solubility in water
Slightly soluble
Melting Point
146.5-148.5
Usage
Medication.

First Aid Measures

Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Skin
Rashes, pruritus, urticaria, and alopecia have been noted but are rare.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
Seizures and syncope have been seen in human overdose. Sedation and ataxia have not been seen in human overdose. With therapeutic use - seizures and tremor have rarely been reported in humans. Animal studies sedation and ataxia have occurred in animals receiving 80 to 500 mg/kg. Seizures and tremor occur in animals receiving 80 to 500 mg/kg. Terfenadine is not teratogenic in rats; teratogenicity was not noted in humans in a multicenter, prospective study.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability
No data.
Incompatibilities
Strong oxidizing agents.
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