Supplier Product Identification Physical and Chemical Properties Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Bicalutamide(90357-06-5)

Supplier Product Identification Physical and Chemical Properties Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Bicalutamide
Synonyms
(2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamide
Casodex
ICI-176334
Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2- methyl-, (+-)
CAS
90357-06-5
Formula
C18H14F4N2O4S
Molecular Weight
430.38
RTECS
TX1413500
Merck
12,1247
Beilstein/Gmelin
5364666

Physical and Chemical Properties

Melting Point
191-193
Vapor Pressure
8.5E-18 (25 C)
Density
1.52 g/cm3 (20 C)
pKa/pKb
11.49 (pKa)
Partition Coefficient
4.94
Usage
An oral non-steroidal anti-androgen for prostate cancer and hirsutism.

Handling and Storage

Storage
Store in original container in a cool dark place.

Hazards Identification

Inhalation
Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.
Skin
Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.
Eyes
Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.
Ingestion
If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.

Exposure Controls/Personal Protection

Personal Protection
Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.

Fire Fighting Measures

Fire Fighting
Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.

Accidental Release Measures

Small spills/leaks
Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.

Stability and Reactivity

Combustion Products
Emits toxic fumes under fire conditions.
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