Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether > 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether(72-33-3)

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether(72-33-3)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
Synonyms
19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-, (17.alpha.)-
3-Methoxyethynylestradiol
8R,9S,13S,14S,17R)-17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
Ethynylestradiol 3-monomethyl ether
Menophase
CAS
72-33-3
Formula
C21H26O2
Molecular Weight
310.44
EINECS
200-777-8
RTECS
RC8960000
RTECS Class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Hormone
Merck
12,5976
Beilstein/Gmelin
2625905
Beilstein Reference
4-06-00-06877

Physical and Chemical Properties

Appearance
White powder
Solubility in water
Practically insoluble
Melting Point
150 - 151.5
Density
1.22 g/cm3
Usage
Hormonal drug.

First Aid Measures

Ingestion
Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage
Do not store in direct sunlight. Store in a tightly closed container. Hormones and antibiotics room. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Use only in a chemical fume hood.

Hazards Identification

Inhalation
May cause respiratory tract irritation.
Skin
May cause skin irritation.
Eyes
May cause mechanical irritation.
Ingestion
May cause nausea and vomiting.

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Exposure Effects
May cause cancer according to animal studies. Reproductive effects have been reported in humans. Cancer suspect agent.
Poison Class
1*

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, acid anhydrides.
Decomposition
Carbon monoxide, carbon dioxide.
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