Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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Etretin(55079-83-9)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
Etretin
Synonyms
9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
Neotigason
Soriatane
CAS
55079-83-9
Formula
C21H26O3
Molecular Weight
326.44
EINECS
259-474-4
RTECS
RA8460000
RTECS Class
Drug; Reproductive Effector; Human Data
Merck
12,114
Beilstein/Gmelin
2158933
Beilstein Reference
6-10

Physical and Chemical Properties

Appearance
White powder.
Solubility in water
Insoluble
Melting Point
219 - 220
Boiling Point
521
Vapor Pressure
1E-11 (25 C)
pKa/pKb
4.79 (pKa)
Heat Of Vaporization
83.6 kJ/mol
Usage
Used to treat severe psoriasis. Only used when other treatments prove ineffective.

First Aid Measures

Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage
Keep tightly closed. Store at 2-8 C

Hazards Identification

Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Skin
Causes skin irritation. May be harmful if absorbed through the skin.
Eyes
Causes eye irritation.
Ingestion
May be harmful if swallowed.
Hazards
Emits toxic fumes under fire conditions.
EC Risk Phrase
61 36/38 50/53
EC Safety Phrase
53 37/39 45 60 61
UN (DOT)
3077

Exposure Controls/Personal Protection

Personal Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Exposure Effects
Toxic. Dangerous for the environment. May cause harm to the unborn child. Irritating to eyes and skin. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Fire Fighting Measures

Flash Point
180
Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire Potential
May burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number
3077
Hazard Class
9
Packing Group
III
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