Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Pancuronium bromide(15500-66-0)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Pancuronium bromide
Synonyms
2b,16b-Dipiperidino-5a-androstane-3a,17b-diol diacetate dimethobromide
Mioblock
Pavulon
Piperidinium, 1,1'-[(2b,3a,5a,16b,17b)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide
CAS
15500-66-0
Formula
C35H60Br2N2O4
Molecular Weight
732.68
EINECS
239-532-5
RTECS
TN4930000
RTECS Class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,7139
Beilstein/Gmelin
4121757
Beilstein Reference
5-20-03-00259

Physical and Chemical Properties

Appearance
White to near-white, hydroscopic crystalline powder with no odor.
Melting Point
214 - 217
Usage
Medication.

First Aid Measures

Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage
Pancuronium bromide should be stored under refrigeration at 2-8C. Keep container tightly closed.
Handling
When protective clothing and respirator when handling this material.

Hazards Identification

Inhalation
Prolonged apnea and respiratory arrest may be noted due to paralysis of the intercostal muscles and diaphragm.
Skin
Absorbed through wonds and skin defects. Paralysis with risk of respiratory failure.
Ingestion
Prolonged apnea and respiratory arrest may be noted due to paralysis of the intercostal muscles and diaphragm.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant (rubber) gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
A supplied (purified) air respirator, hood fit type, breathable air via hose.
Exposure Effects
paralysis of skeletal muscle results in heaviness of the eyelids, difficulty in swallowing and talking, diplopia, progressive weakness of the extremities, the neck, intercostals and diaphragm. Tubocurarine does not penetrate the blood brain barrier hence few CNS effects are noted.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks
Sweep up carefully and transfer to a container and tightly seal. Wear protective equipment.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen bromide.
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