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Valproic acid(99-66-1)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
Valproic acid

Synonyms
2-Propylpentanoic acid
2-Propylvaleric acid
Di-n-propylacetic acid
Mylproin

CAS
99-66-1

Formula
C8H16O2

Molecular Weight
144.21

EINECS
202-777-3

RTECS
YV7875000

RTECS Class
Drug; Reproductive Effector; Human Data

Merck
12,10049

Beilstein/Gmelin
1750447

Beilstein Reference
3-02-00-00807

EC Class
harmful, irritant

Physical and Chemical Properties

Appearance
Clear colorless liquid.

Solubility in water
Soluble

Boiling Point
220

Vapor Pressure
0.044 (25 C)

Density
0.9215 g/cm3 (0 C)

pKa/pKb
4.82 (pKa)

Partition Coefficient
2.75

Heat Of Vaporization
50.3 kJ/mol

Usage
Medication.

Vapor Density
4.97

Refractive Index
1.4236 (20 C)

First Aid Measures

Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage
Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.

Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Do not breathe vapors.

Hazards Identification

Inhalation
Causes chemical burns to the respiratory tract. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Skin
May cause severe irritation and possible burns.

Eyes
Contact with eyes may cause severe irritation, and possible eye burns.

Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May be harmful if swallowed. May cause central nervous system depression. May cause stupor, drowsiness, unconsiousness, or coma (if ingested in large amounts). Causes changes in exocrine pancreas and sleep disturbances.

Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase
R 22 34

EC Safety Phrase
S 26 36/37/39 45

UN (DOT)
3265

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects
May cause reproductive and fetal effects.

Fire Fighting Measures

Flash Point
111

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Water may be ineffective. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential
This chemical is combustible.