Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > 2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one > 2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one(59277-89-3)

2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one(59277-89-3)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one
Synonyms
2-Amino-1,9-dihydro-9-((2-Hydroxyethoxy)methyl)-6H-purin-6-one
9-((2-Hydroxyethoxy)methyl)guanine
Aciclovir
Acycloguanosine
Vipral
Virorax
CAS
59277-89-3
Formula
C8H11N5O3
Molecular Weight
225.21
EINECS
261-685-1
RTECS
UP0791400
RTECS Class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,148
Beilstein/Gmelin
1219402
Beilstein Reference
5-26-18-00045

Physical and Chemical Properties

Appearance
Crystals from methanol.
Solubility in water
Very soluble
pKa/pKb
9.18 (pKa)
Partition Coefficient
-1.76
Heat Of Vaporization
Usage
Medication.

First Aid Measures

Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Skin
Rashes have been seen after therapeutic administration. Reactions at the injection site have also been seen.
Ingestion
Nausea and vomiting are common adverse effects of high-dose therapy with these agents.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
adverse effects include neurotoxicity which resembles an extension of viral infection into the central nervous system. Most commonly, mental status changes and involuntary movements occur. Neurologic toxicity is generally reversible. Seizures have been reported following overdose, but are rare. Lethargy, fatigue, irritability, depression, agitation, stupor and coma have been reported following intravenous acyclovir, particularly rapid infusions. Hallucinations may occur. Occasional myoclonus with muscle fasciculations, hyperactive tendon reflexes, and tremor have been noted with iv use. Headache is common with high doses of these agents.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability
No data.
Incompatibilities
Strong oxidizing agents.
Contact More