Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Heparin(9005-49-6)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Heparin
Synonyms
6-[5-Acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-3-[5-(6-carboxy-4,5-dihydroxy-3-sulfooxyoxan-2-yl)oxy-6-(hydroxymethyl)-3-(sulfoamino)-4-sulfooxyoxan-2-yl]oxy-4-hydroxy-5-sulfooxyoxane-2-carboxylic acid
alpha-Heparin
Depo heparin
HED heparin
Heparinate
Heparinic acid
CAS
9005-49-6
Formula
C26H42N2O37S5
Molecular Weight
1134.93
EINECS
232-681-7
RTECS
MI0700000
RTECS Class
Drug; Mutagen; Reproductive Effector; Human Data; Natural Product
Beilstein/Gmelin
NA

Physical and Chemical Properties

Appearance
White or pale-colored amorphous powder. Nearly odorless.
Solubility in water
soluble
Usage
Anticlotting agent.

First Aid Measures

Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Orally ingested heparin is not absorbed from the gastrointestinal tract and will not result in toxicity. Refer to the parenteral exposure section for treatment recommendations following toxic parenteral exposures.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation
Hemothorax may occur. Pulmonary edema and/or embolism have been reported.
Skin
Hematoma and ecchymoses have been frequently noted especially with intramuscular injections. Skin necrosis is common with subcutaneous heparin injections; dermatitis, eczema, and generalized urticaria have been reported.
Ingestion
Hemothorax may occur. Pulmonary edema and/or embolism have been reported.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
hallucinations and distorted perceptions may occur. Intracerebral hemorrhage has been reported. Compressive neuropathy may occur. Reports of increased rates of abnormal pregnancies and fetal outcomes can be due to maternal co-morbidities. <br>Heparin is classified as Pregnancy Category C.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability
Hygroscopic; ampuled solution may be stored @ room temperature for at least 12 mo sodium salt.
Incompatibilities
Strong oxidizing agents.
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