Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride(61-76-7)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
Synonyms
Benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, hydrochloride, (aR)-
Isophrin hydrochloride
l-m-Hydroxy-a-[(methylamino)methyl]benzyl alcohol hydrochloride
meta-Synephrine hydrochloride
neo-Synephrine hydrochloride
R-(-)-m-Synephrine hydrochloride
CAS
61-76-7
Formula
C9H14ClNO2
Molecular Weight
203.67
EINECS
200-517-3
RTECS
DO7525000
RTECS Class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,7440
Beilstein/Gmelin
4158948
Beilstein Reference
3-13-00-02236

Physical and Chemical Properties

Appearance
Odorless white microcrystalline powder. Bitter taste.
Melting Point
138 - 141
pKa/pKb
pK1 8.77; pK2 9.84(at 25℃) (pKa)
Usage
Adrenergic drug.

First Aid Measures

Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation
May cause respiratory tract irritation.
Skin
May cause skin irritation.
Eyes
May cause eye irritation.
Hazards
Contact with metals may evolve flammable hydrogen gas.
EC Risk Phrase
R 22 36/37/38
EC Safety Phrase
S 26 36/37/39
UN (DOT)
1760

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire Potential
This material is probably combustible.

Accidental Release Measures

Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities
Oxidizing agents, acids, acid chlorides, acid anhydrides.
Stability
Stable under normal temperatures and pressures.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number
1760
Hazard Class
8
Packing Group
I; II; III
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