Colchicine(64-86-8)

Product Name
Colchicine

Synonyms
7-alpha-H-Colchicine
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-(S)-
Benzo[a]heptalen-9(5H)-one
Colchineos
N-Acetyl trimethylcolchicinic acid methyl ether

CAS
64-86-8

Formula
C22H25NO6

Molecular Weight
399.44

EINECS
200-598-5

RTECS
GH0700000

RTECS Class
Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant

Merck
12,2536

Beilstein/Gmelin
2228813

Beilstein Reference
4-14-00-00946

EC Index Number
614-005-00-6

EC Class
Very toxic

Appearance
Pale yellow scales or powder; pale yellow needles when crystallized from odorless or nearly so.

Solubility in water
50 g/L

Melting Point
154 - 156

Density
1.32 g/cm3

pKa/pKb
12.36(at 20℃) (pKa)

Usage
In research in plant genetics (for doubling chromosomes).

Vapor Density
14

Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation
Remove from exposure to fresh air immediately. Get medical aid if cough or other symptoms appear.

Skin
Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.

Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Storage
Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40C.

Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Inhalation
Causes respiratory tract irritation.

Skin
Causes skin irritation.

Eyes
Causes eye irritation.

Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause systemic toxicity with acidosis. Exposure may cause anemia and other blood abnormalities. May produce aplastic anemia, blood pressure depression, body temperature decrease, changes in kidnet tubules, dyspnea, flaccid paralysis without anesthesia, gastrointestinal effects, kidney damage and hemorrhaging, muscle contraction or spasticity, muscle weakness, nausea, vomiting, respiratory stimulation and somnolence. Prolonged ingestion may produce bone marrow depression with agranulocytosis, thrombocytopenia, leukopenia and aplastic anemia may occur with prolonged administration. Lab findings in overdoses have indicated metabolic acidosis, hyponatremia, hypokalemia, bone marrow hypoplasia, thrombocytopenia, granulocytopenia, coagulopathy, and less commonly hemolytic anemia.

Hazards
Stable.

UN (DOT)
2811

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects
May cause bone marrow abnormalities with damage to blood forming tissues.

Poison Class
1*

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential
Slight fire hazard.

Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.

Stability
Stable under normal shipping and handling conditions.

Incompatibilities
Strong oxidizing agents.

Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

UN Number
2811

Hazard Class
6.1

Packing Group
I; II; III