Home > 2-Bromo-2-methylpropionic acid ethyl ester > 2-Bromo-2-methylpropionic acid ethyl ester(600-00-0)
2-Bromo-2-methylpropionic acid ethyl ester(600-00-0)
Supplier Product Identification
Physical and Chemical Properties
First Aid Measures
Handling and Storage
Hazards Identification
Exposure Controls/Personal Protection
Fire Fighting Measures
Accidental Release Measures
Stability and Reactivity
Transport Information
Product Identification
Product Name
2-Bromo-2-methylpropionic acid ethyl ester
2-Bromo-2-methylpropionic acid ethyl ester
Synonyms
2,3,7,8-TCDD
2,3,7,8-Tetrachlorodibenzo[b,e][1,4]dioxin
2,3,7,8-Tetrachlorooxanthrene
a-Bromoisobutyric acid ethyl ester
Dioxin
Dioxine
Ethyl 2-bromo-2-methylpropionate
Ethyl 2-bromoisobutyrate
Ethyl a-bromoisobutyrate
Propanoic acid, 2-bromo-2-methyl-, ethyl ester
2,3,7,8-TCDD
2,3,7,8-Tetrachlorodibenzo[b,e][1,4]dioxin
2,3,7,8-Tetrachlorooxanthrene
a-Bromoisobutyric acid ethyl ester
Dioxin
Dioxine
Ethyl 2-bromo-2-methylpropionate
Ethyl 2-bromoisobutyrate
Ethyl a-bromoisobutyrate
Propanoic acid, 2-bromo-2-methyl-, ethyl ester
CAS
1746-01-6
1746-01-6
CAS
600-00-0
600-00-0
Formula
C12H4Cl4O2
C12H4Cl4O2
Formula
C6H11BrO2
C6H11BrO2
Molecular Weight
321.97000000000003
321.97000000000003
Molecular Weight
195.06
195.06
EINECS
209-980-6
209-980-6
EINECS
217-122-7
217-122-7
RTECS
HP3500000
HP3500000
RTECS Class
Tumorigen; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Tumorigen; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Merck
12,9252
12,9252
Beilstein/Gmelin
1098947
1098947
Beilstein/Gmelin
271116
271116
Beilstein Reference
4-02-00-00862
4-02-00-00862
Beilstein Reference
5-19-02-00041
5-19-02-00041
EC Class
irritant
irritant
Physical and Chemical Properties
Appearance
Clear, colorless liquid.
Clear, colorless liquid.
Appearance
White crystals or tan crystalline powder.
White crystals or tan crystalline powder.
Solubility in water
Insoluble
Insoluble
Solubility in water
0.2 ug/L
0.2 ug/L
Boiling Point
420
420
Boiling Point
65
65
Vapor Pressure
8.3E-7 (25 C)
8.3E-7 (25 C)
Density
1.1323 g/cm3 (0 C)
1.1323 g/cm3 (0 C)
Partition Coefficient
6.95
6.95
Heat Of Vaporization
64.5 kJ/mol
64.5 kJ/mol
Usage
Research chemical.
Research chemical.
Vapor Density
6.73
6.73
Refractive Index
1.4446 (20 C)
1.4446 (20 C)
First Aid Measures
Ingestion
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Ingestion
Right-upper-quadrant pain, anorexia, nausea and vomiting may be early symptoms. Pancreatitis occurred in one case of industrial exposure.
Right-upper-quadrant pain, anorexia, nausea and vomiting may be early symptoms. Pancreatitis occurred in one case of industrial exposure.
Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Inhalation
Dyspnea may be noted.
Dyspnea may be noted.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
Skin
The initial dermal reaction is extensive inflammation of exposed areas with photosensitivity, followed by development of chloracne.
The initial dermal reaction is extensive inflammation of exposed areas with photosensitivity, followed by development of chloracne.
Eyes
Inflammation of the eye, irritation and burning may be noted.
Inflammation of the eye, irritation and burning may be noted.
Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.
Handling and Storage
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Handling
Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Hazards Identification
Ingestion
Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation
Causes respiratory tract irritation. Vapors may cause dizziness or suffocation.
Causes respiratory tract irritation. Vapors may cause dizziness or suffocation.
Skin
Causes skin irritation.
Causes skin irritation.
Eyes
Causes eye irritation. Lachrymator.
Causes eye irritation. Lachrymator.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
EC Risk Phrase
R 34
R 34
EC Safety Phrase
S 26 36/37/39 45
S 26 36/37/39 45
UN (DOT)
1993
1993
Exposure Controls/Personal Protection
Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Personal Protection
For workers engaged in the decontamination process after an accident, it is recommended that they wear complete throw away equipment to protect the skin and prevent exposure to dust and vapors from the contaminated materials. NIOSH approved respiration should be used if any procedure that may produce inhalation of airborne contaminated material cannot be avoided.
For workers engaged in the decontamination process after an accident, it is recommended that they wear complete throw away equipment to protect the skin and prevent exposure to dust and vapors from the contaminated materials. NIOSH approved respiration should be used if any procedure that may produce inhalation of airborne contaminated material cannot be avoided.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
Peripheral neuropathy, with sensory impairment and lower extremity weakness, central neuropathy, mental status changes, headache and dizziness occur after exposure. Mild exposure may result in asymptomatic EMG alterations. Dioxins have not been proven to produce adverse reproductive effects in humans. However, low birthweights, ectodermal dysplasia, and growth and neurological deficits have been associated with dioxin exposure. Data on spontaneous abortions, decreased sperm quality and feminizing alterations of sex hormones have been mixed. TCDD accumulates in breast milk, and neurolgical deficits and increases in T4 and TSH have been associated with lactational exposure. TCDD is considered an animal teratogen.
Peripheral neuropathy, with sensory impairment and lower extremity weakness, central neuropathy, mental status changes, headache and dizziness occur after exposure. Mild exposure may result in asymptomatic EMG alterations. Dioxins have not been proven to produce adverse reproductive effects in humans. However, low birthweights, ectodermal dysplasia, and growth and neurological deficits have been associated with dioxin exposure. Data on spontaneous abortions, decreased sperm quality and feminizing alterations of sex hormones have been mixed. TCDD accumulates in breast milk, and neurolgical deficits and increases in T4 and TSH have been associated with lactational exposure. TCDD is considered an animal teratogen.
Exposure limit(s)
NIOSH REL: Ca See Appendix A
NIOSH REL: Ca See Appendix A
Fire Fighting Measures
Flash Point
164
164
Flash Point
61
61
Fire Fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Containers may explode in the heat of a fire. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Use agent most appropriate to extinguish fire.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Containers may explode in the heat of a fire. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Use agent most appropriate to extinguish fire.
Fire Potential
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
Fire Potential
This material is nonflammable
This material is nonflammable
Accidental Release Measures
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Small spills/leaks
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then using absorbent paper transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then using absorbent paper transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability and Reactivity
Disposal Code
2
2
Stability
Changed chemically when exposed in isooctane or n-octanol to UV light tetrachlorodibenzo-p-dioxin is stable under ordinary conditions of storage. 2,3,7,8-Tcdd is considered relatively stable toward heat, acids, and alkalies.
Changed chemically when exposed in isooctane or n-octanol to UV light tetrachlorodibenzo-p-dioxin is stable under ordinary conditions of storage. 2,3,7,8-Tcdd is considered relatively stable toward heat, acids, and alkalies.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong oxidizing agents, acids, bases.
Strong oxidizing agents, acids, bases.
Incompatibilities
Uv light (decomposes)
Uv light (decomposes)
Decomposition
2,3,7,8-tetrachlorodibenzo-p-dioxin begins to decompose at 500 C and virtually complete decomposition occurs within 21 seconds at a temp of 800 C.
2,3,7,8-tetrachlorodibenzo-p-dioxin begins to decompose at 500 C and virtually complete decomposition occurs within 21 seconds at a temp of 800 C.
Decomposition
Carbon monoxide, carbon dioxide, hydrogen bromide.
Carbon monoxide, carbon dioxide, hydrogen bromide.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.
Fire may produce irritating, corrosive and/or toxic gases.
Transport Information
UN Number
1993
1993
Hazard Class
3
3
Packing Group
I; II; III
I; II; III
HS Code
2915 90 80
2915 90 80
Contact
More
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