Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Ketanserin(74050-98-9)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Ketanserin
Synonyms
2,4(1H,3H)-Quinazolinedione, 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-
3-[2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione
CAS
74050-98-9
Formula
C22H22FN3O3
Molecular Weight
395.43
EINECS
277-680-2
Merck
12,5307

Physical and Chemical Properties

Appearance
White to off-white solid.
Solubility in water
Insoluble
Melting Point
231
Density
1.28 g/cm3 (20 C)
pKa/pKb
6.26 (pKb)
Partition Coefficient
3.21
Usage
Classified as an antihypertensive, serotonin antagonist.

First Aid Measures

Ingestion
Remove dentures and clear mouth. If person is conscious, rinse mouth with water. Call physician or poison control immediately.
Inhalation
Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately.
Skin
Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately.
Eyes
Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately

Handling and Storage

Storage
This product should be stored at room temperature. It should be kept in a tightly closed container.

Exposure Controls/Personal Protection

Personal Protection
For spill clean up, wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or NIOSH/MSHA approved respirator is required.
Exposure Effects
May be harmful if ingested, inhaled, or absorbed through the skin. Symptoms of overexposure can include: low blood pressure, light-headedness, sedation, tremor, convulsions or vomiting.

Fire Fighting Measures

Fire Fighting
Extinguish with carbon dioxide, dry chemical powder, polymer foam, water spray. Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks
Wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed.

Stability and Reactivity

Incompatibilities
Oxidizing agents.
Stability
Stable if stored as directed.
Combustion Products
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Fluorine, Hydrogen fluoride.
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