Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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5-Azacytidine(320-67-2)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
5-Azacytidine
Synonyms
1,3,5-Triazin-2(1H)-one, 4-amino-1-b-D-ribofuranosyl-
Antibiotic U 18496
Azacytidine
s-Triazin-2(1H)-one, 4-amino-1-b-D-ribofuranosyl-
Vidaza
CAS
320-67-2
Formula
C8H12N4O5
Molecular Weight
244.21
EINECS
206-280-2
RTECS
XZ3017500
RTECS Class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Merck
12,923
Beilstein/Gmelin
620461

Physical and Chemical Properties

Appearance
White crystalline powder.
Solubility in water
Very soluble
Melting Point
235
Boiling Point
478
pKa/pKb
13.69 (pKa)
Partition Coefficient
-1.8
Usage
Used in the treatment of myelodysplastic syndrome.

First Aid Measures

Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Deep freeze (below -20 C).
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation
Inhalation of dust may cause respiratory tract irritation.
Skin
Causes skin irritation.
Eyes
Dust may cause mechanical irritation.
Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause blood abnormalities.

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Exposure Effects
May cause cancer in humans.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire Potential
This material is probably combustible.

Accidental Release Measures

Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, oxides of nitrogen, carbon dioxide.
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