Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > 4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester > 4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester(144701-48-4)

4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester(144701-48-4)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester
Synonyms
4'-[[4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
Micardis
CAS
144701-48-4
Formula
C33H30N4O2
Molecular Weight
514.63
Merck
12,10509

Physical and Chemical Properties

Melting Point
261-263
Vapor Pressure
4.6E-25 (25 C)
Density
1.24 g/cm3
pKa/pKb
3.83 (pKa)
Partition Coefficient
7.73
Usage
Angiotensin ii antagonist.

First Aid Measures

Ingestion
Give 3-4 glasses of water, but DO NOT induce vomiting. If vomiting occurs, give fluids again. Get medical attention to determine whether vomiting or evacuation of stomach is necessary. Do not give anything by mouth to an unconscious or convulsing person.
Inhalation
Remove from area to fresh air. Seek medical attention if respiratory irritation develops or if breathing becomes difficult.
Skin
Wash affected areas with plenty of water, and soap if available, for several minutes. Seek medical attention if irritation develops or persists.
Eyes
Remove contact lenses if necessary. Flush eyes with large amounts of running water for at least 15 minutes. Seek medical attention if irritation develops or persists.

Handling and Storage

Storage
Store in a cool, dry place (25 C). The bottles should be kept tightly closed.

Exposure Controls/Personal Protection

Personal Protection
Wear approved respirator and chemically compatible gloves if containers have been compromised and dust is present.
Exposure Effects
Possible reaction to dust if inhaled (breathed), ingested (swallowed), or in contact with eyes. The most common adverse events reported were upper respiratory tract infection, back pain, sinusitis, diarrhea and pharyngitis. See Package Insert for further information. The most likely manifestation of overdosage would be hypotension, dizziness, and tachycardia; bradycardia could occur from vagal stimulation. Supportive treatment should be instituted. Telmisartan is not removed by hemodialysis. CHRONIC EXPOSURE: May reduce blood pressure. MEDICAL CONDITIONS POTENTIALLY AGGRAVATED BY EXPOSURE: Dust allergies, and pre-existing respiratory conditions and anyone who is hypersensitive to any component of this product. Persons with low blood volume, and hepatic insufficiency may be at additional risk.

Fire Fighting Measures

Fire Fighting
Use water spray, foam, CO2, or dry chemical agents to extinguish fires. evacuate personnel to safe area. Firefighters should use self-contained breathing equipment and protective clothing. Use water s pray to keep fire-exposed containers cool.

Accidental Release Measures

Small spills/leaks
Vacuum or sweep up spillage. Avoid creating dust. Very fine particles can cause a fire or explosion; therefore, eliminate all sources of ignition. Place spillage in appropriate container for waste disposal. Wash contaminated clothing before reuse. Ventilate area, wash down spill site and control wash water.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Decomposition
When heated to decomposition or under fire conditions, material emits oxides of carbon and nitrogen.
Combustion Products
Acrid, flammable fumes may develop in a fire.
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