Pemoline(2152-34-3)

Product Name
Pemoline

Synonyms
2-Amino-5-phenyl-4(5h)-oxazolone
Azoksodon
Azoxodone
Centramin
Constimol
Cs 293

CAS
2152-34-3

Formula
C9H8N2O2

Molecular Weight
176.17

EINECS
218-438-8

RTECS
RQ2975000

RTECS Class
Drug; Reproductive Effector; Human Data

Merck
12,7206

Beilstein/Gmelin
151559

Beilstein Reference
4-27-00-05622

Appearance
Crystals.

Solubility in water
Insoluble

Melting Point
218

Boiling Point
322

pKa/pKb
3.50 (pKb)

Partition Coefficient
1.27

Usage
Medication.

Ingestion
Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.

Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Inhalation
Tachypnea is common. Pulmonary hypertension has been associated with chronic use or abuse which may result from contaminants. Pulmonary edema and ards are unusual complications of severe exposure.

Skin
The skin is usually flushed and diaphoretic.

Ingestion
Vomiting, diarrhea, cramps, anorexia and gastrointestinal hemorrhage may occur.

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects
Severe elevated body temperature may develop. Elevated blood pressure and rapid heart rate are common. Agitation, confusion, paranoia, delirium, hallucinations, restlessness, hyperactivity, talkativeness, irritability, insomnia, and headache are common. Chorea, dystonia, fasciculations, muscle rigidity, tics, and tremors may develop. Seizures and coma may occur with severe intoxication. Other neurological effects have included stroke and cerebral vasculitis. Serotonin syndrome has occurred.

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability
No data.

Incompatibilities
Strong oxidizing agents.