Home > Ketamine hydrochloride > Ketamine hydrochloride(1867-66-9)
Ketamine hydrochloride(1867-66-9)
Product Identification
Physical and Chemical Properties
First Aid Measures
Handling and Storage
Hazards Identification
Exposure Controls/Personal Protection
Fire Fighting Measures
Accidental Release Measures
Stability and Reactivity
Product Identification
Product Name
Ketamine hydrochloride
Ketamine hydrochloride
Synonyms
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Calipsol
CI 581
Kalipsol
Ketaset
Vetalar
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Calipsol
CI 581
Kalipsol
Ketaset
Vetalar
CAS
1867-66-9
1867-66-9
Formula
C13H16ClNO.ClH
C13H16ClNO.ClH
Molecular Weight
274.20999999999998
274.20999999999998
EINECS
217-484-6
217-484-6
RTECS
GW1400000
GW1400000
RTECS Class
Drug; Mutagen; Reproductive Effector; Human Data
Drug; Mutagen; Reproductive Effector; Human Data
Beilstein/Gmelin
5318526
5318526
Beilstein Reference
6-14
6-14
Physical and Chemical Properties
Appearance
Colorless to white crystals.
Colorless to white crystals.
Solubility in water
0.2 g/mL (20 C)
0.2 g/mL (20 C)
Melting Point
262 - 263
262 - 263
pKa/pKb
7.5(at 25℃) (pKa)
7.5(at 25℃) (pKa)
Usage
Medication. Selective nmda glutamate receptor antagonist; veterinary anesthetic.
Medication. Selective nmda glutamate receptor antagonist; veterinary anesthetic.
First Aid Measures
Ingestion
Benzodiazepines or droperidol and minimization of sensory stimuli may reduce the incidence of psychotomimetic effects of ketamine. Administer oxygen and manage airway as clinically indicated.
Benzodiazepines or droperidol and minimization of sensory stimuli may reduce the incidence of psychotomimetic effects of ketamine. Administer oxygen and manage airway as clinically indicated.
Inhalation
See ingestion.
See ingestion.
Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists.
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists.
Eyes
Irrigate eye for at least 20 minutes with water or saline. If irritation persists, seek medical attention.
Irrigate eye for at least 20 minutes with water or saline. If irritation persists, seek medical attention.
Handling and Storage
Storage
Keep tightly closed. Store at 2-8 C
Keep tightly closed. Store at 2-8 C
Hazards Identification
Inhalation
Respiratory depression, apnea, and respiratory arrest may occur. Ketamine may produce bronchodilation and increased salivary and tracheobronchial secretions.
Respiratory depression, apnea, and respiratory arrest may occur. Ketamine may produce bronchodilation and increased salivary and tracheobronchial secretions.
Skin
May be harmful if absorbed through the skin.
May be harmful if absorbed through the skin.
Eyes
Temporary loss of vision or blurred vision may be noted.
Temporary loss of vision or blurred vision may be noted.
Ingestion
Nausea and vomiting have been reported.
Nausea and vomiting have been reported.
Hazards
Emits toxic fumes under fire conditions.
Emits toxic fumes under fire conditions.
EC Risk Phrase
22 36/37/38 40
22 36/37/38 40
EC Safety Phrase
26 36
26 36
Exposure Controls/Personal Protection
Personal Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Government approved respirator.
Exposure Effects
Sedation and respiratory depression have been reported after overdose in medical settings. Patients usually awaken within a few hours, although sedation lasting 24 hours has been described. Ketamine has become a drug of abuse. Common effects include tachycardia, altered mental status, anxiety, palpitations, slurred speech hallucinations, nystagmus, mydriasis, mild hypertension and chest pain. Confusion, vomiting and memory loss are less common. Rarely seizures, polyneuropathy, or respiratory arrest may occur. Death is rare following ketamine abuse or overdose.
Sedation and respiratory depression have been reported after overdose in medical settings. Patients usually awaken within a few hours, although sedation lasting 24 hours has been described. Ketamine has become a drug of abuse. Common effects include tachycardia, altered mental status, anxiety, palpitations, slurred speech hallucinations, nystagmus, mydriasis, mild hypertension and chest pain. Confusion, vomiting and memory loss are less common. Rarely seizures, polyneuropathy, or respiratory arrest may occur. Death is rare following ketamine abuse or overdose.
Fire Fighting Measures
Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Accidental Release Measures
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability and Reactivity
Incompatibilities
Oxidizing agents.
Oxidizing agents.
Stability
Stable at normal temperatures and pressures.
Stable at normal temperatures and pressures.
Decomposition
When heated to decomposition, the material emits fumes of HCl and NOx.
When heated to decomposition, the material emits fumes of HCl and NOx.