Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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Propofol(2078-54-8)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
Propofol
Synonyms
2,6-Bis(1-methylethyl)phenol
2,6-Bis(isopropyl)phenol
2,6-Diisopropylphenol
Diprofol
Disoprivan
Recofol
CAS
2078-54-8
Formula
C12H18O
Molecular Weight
178.27
EINECS
218-206-6
RTECS
SL0810000
RTECS Class
Drug; Reproductive Effector; Human Data
Merck
12,8020
Beilstein/Gmelin
1866484
Beilstein Reference
4-06-00-03435

Physical and Chemical Properties

Appearance
Yellow-tan liquid.
Solubility in water
Insoluble
Melting Point
18
Boiling Point
256
Vapor Pressure
0.01 (25 C)
Density
1.032 g/cm3
pKa/pKb
11.00 (pKa)
Partition Coefficient
4.16
Heat Of Vaporization
51.3 kJ/mol
Usage
An intravenous sedative-hypnotic agent.
Refractive Index
1.5134 (20 C)

First Aid Measures

Ingestion
Get medical aid. Wash mouth out with water.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage
Store in a cool, dry place. Store in a tightly closed container. Keep under an argon blanket. Refrigerator (approx 4 C).
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Use only in a chemical fume hood.

Hazards Identification

Ingestion
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation
Dust is irritating to the respiratory tract. The toxicological properties of this substance have not been fully investigated.
Skin
Causes skin irritation.
Eyes
Causes eye irritation.
EC Risk Phrase
R 22 36/38
EC Safety Phrase
S 26 36/37/39
UN (DOT)
2810

Exposure Controls/Personal Protection

Personal Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point
107
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures

Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.

Stability and Reactivity

Incompatibilities
Oxidizing agents, bases, acid chlorides, acid anhydrides.
Stability
Stable under normal temperatures and pressures.
Decomposition
Carbon monoxide, carbon dioxide.

Transport Information

UN Number
2810
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